| PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1. | PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1.
Nakata Y, Nagasawa S, Sera Y, Yamasaki N, Kanai A, Kobatake K, Ueda T, Koizumi M, Manabe I, Kaminuma O, Honda H., Free PMC Article | 08/16/2024 |
| Ptip is essential for tooth development via regulating Wnt pathway. | Ptip is essential for tooth development via regulating Wnt pathway.
Liang J, Wang J, Ye C, Bai Y, Tong Y, Li Y, Ji Y, Zhang Y. | 06/12/2024 |
| Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity. | Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity.
Zhang T, Cui M, Li Y, Cheng Y, Gao Z, Wang J, Zhang T, Han G, Yin R, Wang P, Tian W, Liu W, Hu J, Wang Y, Liu Z, Zhang H., Free PMC Article | 09/8/2023 |
| PTIP Deficiency in B Lymphocytes Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. | PTIP Deficiency in B Lymphocytes Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.
Liu J, Xu Y, Chen YQ, Su D. | 06/7/2023 |
| PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation. | PTIP governs NAD(+) metabolism by regulating CD38 expression to drive macrophage inflammation.
Wang Q, Hu J, Han G, Wang P, Li S, Chang J, Gao K, Yin R, Li Y, Zhang T, Chai J, Gao Z, Zhang T, Cheng Y, Guo C, Wang J, Liu W, Cui M, Xu Y, Hou J, Zhu QF, Feng YQ, Zhang H. | 04/9/2022 |
| DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity. | DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity.
Cao A, Li J, Asadi M, Basgen JM, Zhu B, Yi Z, Jiang S, Doke T, El Shamy O, Patel N, Cravedi P, Azeloglu EU, Campbell KN, Menon M, Coca S, Zhang W, Wang H, Zen K, Liu Z, Murphy B, He JC, D'Agati VD, Susztak K, Kaufman L., Free PMC Article | 10/9/2021 |
| PTIP Deficiency in B Lymphocytes Reduces Subcutaneous Fat Deposition in Mice. | PTIP Deficiency in B Lymphocytes Reduces Subcutaneous Fat Deposition in Mice.
Xu Y, Zhu D, Yang Q, Su D, Chen YQ. | 07/10/2021 |
| Regeneration after acute kidney injury requires PTIP-mediated epigenetic modifications. | Regeneration after acute kidney injury requires PTIP-mediated epigenetic modifications.
Soofi A, Kutschat AP, Azam M, Laszczyk AM, Dressler GR., Free PMC Article | 06/26/2021 |
| lncRNA Gm10451 regulates PTIP to facilitate iPSCs-derived beta-like cell differentiation by targeting miR-338-3p as a ceRNA. | lncRNA Gm10451 regulates PTIP to facilitate iPSCs-derived β-like cell differentiation by targeting miR-338-3p as a ceRNA.
Huang Y, Xu Y, Lu Y, Zhu S, Guo Y, Sun C, Xu L, Chen X, Zhao Y, Yu B, Yang Y, Wang Z. | 10/3/2020 |
| PTIP as an epigenetic regulator of osteoclastogenesis. | Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Das P, Veazey KJ, Van HT, Kaushik S, Lin K, Lu Y, Ishii M, Kikuta J, Ge K, Nussenzweig A, Santos MA., Free PMC Article | 12/22/2018 |
| The role for PTIP in promoting sterile transcription at the Igh locus. | PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice.
Su D, Vanhee S, Soria R, Gyllenbäck EJ, Starnes LM, Højfeldt MK, Pedersen GK, Yuan J, Daniel JA., Free PMC Article | 06/23/2018 |
| a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR | A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, Yuan J, Ge K, Montoya G, Nussenzweig A, Choudhary C, Daniel JA., Free PMC Article | 05/21/2016 |
| Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP. | 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A., Free PMC Article | 08/31/2013 |
| Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability. | A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.
Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR., Free PMC Article | 03/16/2013 |
| PAXIP1 controls distinct transcriptional programs during DP differentiation necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural killer T cell development. | The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A., Free PMC Article | 02/9/2013 |
| PTIP plays an important role in the DNA repair process associated with the development of mature spermatozoa. | Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes.
Schwab KR, Smith GD, Dressler GR., Free PMC Article | 01/26/2013 |
| PTIP stabilizes the Pax5 DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination. | Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.
Schwab KR, Patel SR, Dressler GR., Free PMC Article | 05/21/2011 |
| Data show that loss of PTIP resulting in subtle changes in gene expression patterns and lower H3K4 methylation. | Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.
Lefevre GM, Patel SR, Kim D, Tessarollo L, Dressler GR., Free PMC Article | 03/12/2011 |
| PTIP accumulation at double stranded breaks contributes to class switch recombination and genome stability independently of Igh switch transcription | PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A., Free PMC Article | 09/6/2010 |
| The results suggest that the maintenance of H3K4 methylation is essential and requires PTIP function during the in vitro propagation of pluripotent ES cells. | The role of PTIP in maintaining embryonic stem cell pluripotency.
Kim D, Patel SR, Xiao H, Dressler GR., Free PMC Article | 01/21/2010 |
| The PTIP regulates PPAR gamma and C/EBPalpha expression in mouse embryonic fibroblasts as well as during preadipocyte differentiation. | Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis.
Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K., Free PMC Article | 01/21/2010 |
| subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage. | Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
Gong Z, Cho YW, Kim JE, Ge K, Chen J., Free PMC Article | 01/21/2010 |
| These and other data suggest that PTIP has multiple functions, one of which is to promote the formation of transcriptional complexes that provide specificity of developmental gene expression. | An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development.
Mu W, Wang W, Schimenti JC., Free PMC Article | 01/21/2010 |
| PTIP bridges DNA-binding developmental regulators to histone methyltransferase-dependent epigenetic regulation. | The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
Patel SR, Kim D, Levitan I, Dressler GR., Free PMC Article | 01/21/2010 |
| PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways | BRCT domain-containing protein PTIP is essential for progression through mitosis.
Cho EA, Prindle MJ, Dressler GR., Free PMC Article | 01/21/2010 |