| Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout. | Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout.
Vávra J, Pavelcová K, Mašínová J, Hasíková L, Bubeníková E, Urbanová A, Mančíková A, Stibůrková B., Free PMC Article | 02/15/2024 |
| The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling. | The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling.
Yu Z, Wang H, You G., Free PMC Article | 09/7/2023 |
| Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4). | Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4).
Louisse J, Dellafiora L, van den Heuvel JJMW, Rijkers D, Leenders L, Dorne JCM, Punt A, Russel FGM, Koenderink JB., Free PMC Article | 03/3/2023 |
| our study discovered 3 novel population-specific functional genetic variants (rs6913677, rs2078267, rs8100011) in 2 novel (SLC22A11 and ZNF45) and 1 earlier reported gene (BAI3) for BMI in Indians. Our study decodes key genomic loci underlying obesity phenotype in Indians that may serve as prospective drug targets in future | Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians.
Giri AK, Prasad G, Bandesh K, Parekatt V, Mahajan A, Banerjee P, Kauser Y, Chakraborty S, Rajashekar D, INDICO, Sharma A, Mathur SK, Basu A, McCarthy MI, Tandon N, Bharadwaj D. | 06/27/2020 |
| The first genome-wide association study for serum uric acid level in Indians revealed association of SLC2A9, SLC22A11 and ABCG2 gene variants at genome wide significance level in Type 2 diabetes patients. | Genome wide association study of uric acid in Indian population and interaction of identified variants with Type 2 diabetes.
Giri AK, Banerjee P, Chakraborty S, Kauser Y, Undru A, Roy S, Parekatt V, Ghosh S, Tandon N, Bharadwaj D., Free PMC Article | 12/24/2016 |
| modifies placental passage of perfluorinated alkyl acids, may decrease fetal exposure | Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system.
Kummu M, Sieppi E, Koponen J, Laatio L, Vähäkangas K, Kiviranta H, Rautio A, Myllynen P. | 08/27/2016 |
| The regulation of hOAT4 activity was mediated by sgk2 acting through Nedd4-2. | Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.
Wang H, Xu D, Toh MF, Pao AC, You G., Free PMC Article | 07/2/2016 |
| SLC22A11 at the basal plasma membrane of human placental syncytiotrophoblasts plays a predominant role in the uptake of 16alpha-OH DHEAS for placental estriol synthesis. | Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus.
Tomi M, Eguchi H, Ozaki M, Tawara T, Nishimura S, Higuchi K, Maruyama T, Nishimura T, Nakashima E. | 08/29/2015 |
| A common variant of OAT4/SLC22A11 is associated with renal underexcretion type gout in Japanese men. | A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout.
Sakiyama M, Matsuo H, Shimizu S, Nakashima H, Nakayama A, Chiba T, Naito M, Takada T, Suzuki H, Hamajima N, Ichida K, Shimizu T, Shinomiya N. | 12/20/2014 |
| Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 locus that presumably influence the activity of OAT4 and URAT1 and risk of gout. | Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects.
Flynn TJ, Phipps-Green A, Hollis-Moffatt JE, Merriman ME, Topless R, Montgomery G, Chapman B, Stamp LK, Dalbeth N, Merriman TR., Free PMC Article | 11/8/2014 |
| When investigating the genes separately, SLC22A11 and SLC2A9 showed a significant interaction, consistent with the former encoding an organic anion/dicarboxylate exchanger, which mediates diuretic transport in the kidney. | A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study.
McAdams-DeMarco MA, Maynard JW, Baer AN, Kao LW, Kottgen A, Coresh J., Free PMC Article | 07/6/2013 |
| Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) | Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
Yang Q, Köttgen A, Dehghan A, Smith AV, Glazer NL, Chen MH, Chasman DI, Aspelund T, Eiriksdottir G, Harris TB, Launer L, Nalls M, Hernandez D, Arking DE, Boerwinkle E, Grove ML, Li M, Linda Kao WH, Chonchol M, Haritunians T, Li G, Lumley T, Psaty BM, Shlipak M, Hwang SJ, Larson MG, O'Donnell CJ, Upadhyay A, van Duijn CM, Hofman A, Rivadeneira F, Stricker B, Uitterlinden AG, Paré G, Parker AN, Ridker PM, Siscovick DS, Gudnason V, Witteman JC, Fox CS, Coresh J., Free PMC Article | 12/5/2010 |
| Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. | Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.
Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM, Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM., Free PMC Articles: PMC2957254, PMC2957254 | 10/30/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.
Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM, Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM., Free PMC Articles: PMC2957254, PMC2957254 | 09/15/2010 |
| The down-regulation of hOAT4 activity by activation of protein kinase C and the up-regulation of hOAT4 activity by NHERF-1 are mediated through alteration of hOAT4 internalization. | Regulation of human organic anion transporter 4 by protein kinase C and NHERF-1: altering the endocytosis of the transporter.
Zhang Q, Pan Z, You G., Free PMC Article | 06/14/2010 |
| Several naturally occurring SNPs encode variant hOAT4s that may impair the renal tubular re-absorption of important drug substrates. | Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4).
Zhou F, Zhu L, Cui PH, Church WB, Murray M., Free PMC Article | 05/31/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H, EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI, ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H, PROCARDIS Consortium, Doering A, Wichmann HE, KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M, WTCCC, Illig T, Gieger C., Free PMC Article | 06/24/2009 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesGender is an important determinant of the disposition of the loop diuretic torasemide.
Werner U, Werner D, Heinbüchner S, Graf B, Ince H, Kische S, Thürmann P, König J, Fromm MF, Zolk O. Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.
Rodríguez-Nóvoa S, Labarga P, Soriano V, Egan D, Albalater M, Morello J, Cuenca L, González-Pardo G, Khoo S, Back D, Owen A. | 05/17/2009 |
| Findings suggest that hOAT4 and caveolin-1 share a cellular expression in the plasma membrane and caveolin-1 up-regulates the organic anionic compound uptake by hOAT4 under the normal physiological condition. | Co-localization and interaction of human organic anion transporter 4 with caveolin-1 in primary cultured human placental trophoblasts.
Lee WK, Choi JK, Cha SH., Free PMC Article | 01/21/2010 |
| The present study demonstrates that hOAT4 variants can causing inter-individual variation in anionic drug uptake and, therefore, could be used as markers for certain diseases including osteoporosis. | Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients.
Lee WK, Kwak JO, Hwang JS, Suh CK, Cha SH, Lee WK, Kwak JO, Hwang JS, Suh CK, Cha SH. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesCommon polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.
Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, Hengstenberg C. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.
van der Harst P, Bakker SJ, de Boer RA, Wolffenbuttel BH, Johnson T, Caulfield MJ, Navis G. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N. Identification and characterization of single nucleotide polymorphisms of SLC22A11 (hOAT4) in Korean women osteoporosis patients.
Lee WK, Kwak JO, Hwang JS, Suh CK, Cha SH, Lee WK, Kwak JO, Hwang JS, Suh CK, Cha SH. | 05/11/2008 |
| The interaction of PDZ proteins with hOAT4 may be cell-specific. In placenta, a different set of interacting proteins from PDZK1 and NHERF1 may be required to modulate hOAT4 activity. | Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells.
Zhou F, Xu W, Tanaka K, You G. | 01/21/2010 |
| hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia. | Human renal organic anion transporter 4 operates as an asymmetric urate transporter.
Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A. | 01/21/2010 |
| elucidation of the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs | Human organic anion transporters mediate the transport of tetracycline.
Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H. | 01/21/2010 |
| Glycosylation serves as a means to specifically regulate hOAT4 function in vivo. | The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4.
Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G. | 01/21/2010 |