| Results identified and confirmed to have downregulated gene expression of SFRP5 in sporadic nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and CDCA7L and RBM47 in MEN1-related NFPanNETs. | Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors.
Tirosh A, Mukherjee S, Lack J, Gara SK, Wang S, Quezado MM, Keutgen XM, Wu X, Cam M, Kumar S, Patel D, Nilubol N, Tyagi MV, Kebebew E., Free PMC Article | 01/18/2020 |
| CDCA7L is highly expressed in human glioma tissues and that a high CDCA7L expression predicts a poor prognosis of glioma patients. CDCA7L promotes glioma U87 cell growth through CCND1. | CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.
Ji QK, Ma JW, Liu RH, Li XS, Shen FZ, Huang LY, Hui L, Ma YJ, Jin BZ., Free PMC Article | 01/4/2020 |
| Study demonstrated the elevated expression of R1 in human prostate cancer tissue and cell lines at both protein and mRNA levels. Further results provide evidence that R1 is a novel regulator of prostate tumor growth by stabilizing c-Myc protein through transcriptional suppression of HUWE1. | R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
Lin TP, Li J, Li Q, Li X, Liu C, Zeng N, Huang JM, Chu GC, Lin CH, Zhau HE, Chung LWK, Wu BJ, Shih JC. | 08/31/2019 |
| CDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients | Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.
Shen FZ, Li XS, Ma JW, Wang XY, Zhao SP, Meng L, Liang SF, Zhao XL. | 02/9/2019 |
| Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis. | Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression.
Li N, Johnson DC, Weinhold N, Studd JB, Orlando G, Mirabella F, Mitchell JS, Meissner T, Kaiser M, Goldschmidt H, Hemminki K, Morgan GJ, Houlston RS., Free PMC Article | 09/29/2018 |
| We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma | JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
Chan TS, Hawkins C, Krieger JR, McGlade CJ, Huang A. | 07/29/2017 |
| common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN | Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck J, Veverka V, Řezáčová P. | 05/14/2016 |
| The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC. | The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.
Weinhold N, Meissner T, Johnson DC, Seckinger A, Moreaux J, Försti A, Chen B, Nickel J, Chubb D, Rawstron AC, Doughty C, Dahir NB, Begum DB, Young K, Walker BA, Hoffmann P, Nöthen MM, Davies FE, Klein B, Goldschmidt H, Morgan GJ, Houlston RS, Hose D, Hemminki K., Free PMC Article | 10/3/2015 |
| Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75. | Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.
Hendrix J, van Heertum B, Vanstreels E, Daelemans D, De Rijck J., Free PMC Article | 08/9/2014 |
| CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression. | CDCA7L promotes hepatocellular carcinoma progression by regulating the cell cycle.
Tian Y, Huang C, Zhang H, Ni Q, Han S, Wang D, Han Z, Li X. | 07/19/2014 |
| Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A protein levels within the major depressive disorder groups compared with controls. | The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder.
Johnson S, Stockmeier CA, Meyer JH, Austin MC, Albert PR, Wang J, May WL, Rajkowska G, Overholser JC, Jurjus G, Dieter L, Johnson C, Sittman DB, Ou XM., Free PMC Article | 06/9/2012 |
| Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 | Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.
Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F. | 01/21/2010 |
| monoamine oxidase A activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 | Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1.
Ou XM, Chen K, Shih JC. | 01/21/2010 |
| demonstrates the functions of MAO A and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways | Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.
Ou XM, Chen K, Shih JC., Free PMC Article | 01/21/2010 |