| HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia. | HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia.
Jing M, Xiong X, Mao X, Song Q, Zhang L, Ouyang Y, Pang Y, Fu Y, Yan W., Free PMC Article | 02/23/2024 |
| Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK. | Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.
Baltrusaitis EE, Ravitch EE, Fenton AR, Perez TA, Holzbaur ELF, Dominguez R., Free PMC Article | 01/3/2024 |
| Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis. | Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.
Peng YY, Sun D, Xin Y., Free PMC Article | 04/16/2022 |
| Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels. | Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels.
Fatiga FF, Wang LJ, Hsu T, Capuno JI, Fu CY. | 03/19/2022 |
| Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5. | Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5.
Ren X, Yu J, Guo L, Ma H., Free PMC Article | 02/5/2022 |
| Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase. | Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase.
Smith KP, Focia PJ, Chakravarthy S, Landahl EC, Klosowiak JL, Rice SE, Freymann DM., Free PMC Article | 10/16/2021 |
| The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset. | The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.
Periñán MT, Gómez-Garre P, Blauwendraat C, Mir P, Bandres-Ciga S, International Parkinson’s Disease Genomics Consortium (IPDGC)., Free PMC Article | 09/4/2021 |
| Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson's disease. | Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson's disease.
Berenguer-Escuder C, Grossmann D, Antony P, Arena G, Wasner K, Massart F, Jarazo J, Walter J, Schwamborn JC, Grünewald A, Krüger R., Free PMC Article | 08/7/2021 |
| Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer. | Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer.
Zhang H, Ge Z, Wang Z, Gao Y, Wang Y, Qu X., Free PMC Article | 07/24/2021 |
| Miro: A molecular switch at the center of mitochondrial regulation. | Miro: A molecular switch at the center of mitochondrial regulation.
Eberhardt EL, Ludlam AV, Tan Z, Cianfrocco MA., Free PMC Article | 02/27/2021 |
| The ROTH1 is a genetic risk factor for Parkinson's disease, further implicating Miro1 in calcium homeostasis and mitochondrial quality control. | Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease.
Grossmann D, Berenguer-Escuder C, Bellet ME, Scheibner D, Bohler J, Massart F, Rapaport D, Skupin A, Fouquier d'Hérouël A, Sharma M, Ghelfi J, Raković A, Lichtner P, Antony P, Glaab E, May P, Dimmer KS, Fitzgerald JC, Grünewald A, Krüger R., Free PMC Article | 08/15/2020 |
| circRHOT1 inhibits HCC development and progression via recruiting TIP60 to initiate NR2F6 expression, indicating that circRHOT1 and NR2F6 may be potential biomarkers for HCC prognosis. | Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression.
Wang L, Long H, Zheng Q, Bo X, Xiao X, Li B., Free PMC Article | 04/4/2020 |
| Results find that Miro1 is not only a substrate for PINK1/ Parkin-dependent degradation but might also function as a calcium-dependent docking site and safety switch for Parkin recruitment in mitochondria. | Miro proteins prime mitochondria for Parkin translocation and mitophagy.
Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A., Free PMC Article | 12/28/2019 |
| Miro1 binds directly to a C-terminal fragment of the Myo19 tail region and that Miro1/2 recruit the Myo19 tail. | Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.
Oeding SJ, Majstrowicz K, Hu XP, Schwarz V, Freitag A, Honnert U, Nikolaus P, Bähler M. | 12/7/2019 |
| circRHOT1 was overexpressed in pancreatic cancer and that this circRHOT1 was predominantly located in the cytoplasm. Reducing the circRHOT1 expression inhibited pancreatic cancer cell proliferation, invasion and migration. CircRHOT1 may play important roles in pancreatic cancer through sponging tumor-associated miRNAs | Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer.
Qu S, Hao X, Song W, Niu K, Yang X, Zhang X, Shang R, Wang Q, Li H, Liu Z. | 08/17/2019 |
| the data presented here indicate novel catalytic functions of human Miro atypical GTPases through altered catalytic mechanisms. | Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.
Peters DT, Kay L, Eswaran J, Lakey JH, Soundararajan M., Free PMC Article | 03/30/2019 |
| The findings identify for the first time peroxisome-localized Miro1 variants as adapter proteins that link peroxisomes to the microtubule-dependent transport complexes including TRAK2 in the intracellular translocation of peroxisomes in mammalian cells. | New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes.
Okumoto K, Ono T, Toyama R, Shimomura A, Nagata A, Fujiki Y., Free PMC Article | 12/22/2018 |
| LPS mediates intercellular tight junction destruction among TECs and RhoT1/SMAD-4/JAM-3 is a pivotal pathway to mediate the phenomenon. | Lipopolysaccharide Mediates the Destruction of Intercellular Tight Junction among Renal Tubular Epithelial Cells via RhoT1/SMAD-4/JAM-3 Pathway.
Zheng S, Lin Z, Liu Z, Liu Y, Wu W., Free PMC Article | 09/22/2018 |
| a key role of Miro1, which promotes the mitochondrial transfer from multipotent mesenchymal stem cells, is reported. | Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery.
Babenko VA, Silachev DN, Popkov VA, Zorova LD, Pevzner IB, Plotnikov EY, Sukhikh GT, Zorov DB., Free PMC Article | 09/8/2018 |
| Show that the C-terminal GTPase of the Parkin primary substrates Miro1 and Miro2 are necessary and sufficient for efficient ubiquitination. We present several new X-ray crystal structures of both Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues. | Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Klosowiak JL, Park S, Smith KP, French ME, Focia PJ, Freymann DM, Rice SE., Free PMC Article | 06/9/2018 |
| Results provide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parkin-dependent Miro1 degradation. | Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
Moller A, Bauer CS, Cohen RN, Webster CP, De Vos KJ., Free PMC Article | 05/26/2018 |
| prolonged retention of Miro, and the downstream consequences that ensue, may constitute a central component of Parkinson's disease pathogenesis. | Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD, Wang X., Free PMC Article | 07/22/2017 |
| Full-length APC promotes assembly of the Miro-1/Milton-2 complex. | APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Mills KM, Brocardo MG, Henderson BR., Free PMC Article | 10/29/2016 |
| Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. | Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.
Kanfer G, Courthéoux T, Peterka M, Meier S, Soste M, Melnik A, Reis K, Aspenström P, Peter M, Picotti P, Kornmann B., Free PMC Article | 04/30/2016 |
| Data indicate that outer mitochondrial membrane protein Miro1 can stabilize phospho-mutant versions of PARK2 gene (encoding Parkin) on the outer mitochondrial membrane (OMM). | Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT., Free PMC Article | 11/8/2014 |