| High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increase susceptibility to increased insulin resistance by 50% and its risk may be exacerbated by consuming more than 10 cups coffee/week or 220 mg caffeine/day. | High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.
Daily JW, Liu M, Park S. | 03/16/2019 |
| B55gamma is induced by glucocorticoid receptor in human primary BM-MSCs during differentiation to osteoblast and is required for osteoblast morphogenesis. | PP2A Regulatory Subunit B55γ is a Gatekeeper of Osteoblast Maturation and Lineage Maintenance.
Serguienko A, Hanes R, Grad I, Wang MY, Myklebost O, Munthe E. | 05/26/2018 |
| miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C. | miR-1301 promotes prostate cancer proliferation through directly targeting PPP2R2C.
Bi D, Ning H, Liu S, Que X, Ding K. | 01/28/2017 |
| These findings provide insights into mechanisms by which prostate cancers resist AR-pathway suppression and support inhibiting PPP2R2C complexes. | PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality.
Bluemn EG, Spencer ES, Mecham B, Gordon RR, Coleman I, Lewinshtein D, Mostaghel E, Zhang X, Annis J, Grandori C, Porter C, Nelson PS., Free PMC Article | 04/19/2014 |
| PPP2R2C is a potential tumor suppressor gene in human brain cancers. | Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.
Fan YL, Chen L, Wang J, Yao Q, Wan JQ. | 02/22/2014 |
| evidence suggests that allelic variation in PPP2R2C may be associated with a variety of personality traits and ADHD per se. | PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD.
Jacob C, Nguyen TT, Weißflog L, Herrmann M, Liedel S, Zamzow K, Jans T, Renner T, Reichert S, Groß-Lesch S, Lesch KP, Reif A. | 02/2/2013 |
| encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity | PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.
Backx L, Vermeesch J, Pijkels E, de Ravel T, Seuntjens E, Van Esch H. | 01/15/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesIntegrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Kim S, Webster MJ. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R. | 09/20/2009 |
| novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma | A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.
Eichhorn PJ, Creyghton MP, Wilhelmsen K, van Dam H, Bernards R., Free PMC Article | 01/21/2010 |
| specific PP2A complexes involved in human cell transformation | Identification of specific PP2A complexes involved in human cell transformation.
Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC. | 01/21/2010 |