| Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT via regulating ZEB1 expression. | Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT via regulating ZEB1 expression.
Zhao H, Liu C, Zhao C, Che C, Liu W, Mei Y. | 02/11/2023 |
| Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer. | Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer.
Marx A, Luebke AM, Clauditz TS, Steurer S, Fraune C, Hube-Magg C, Büscheck F, Höflmayer D, Tsourlakis MC, Möller-Koop C, Simon R, Sauter G, Göbel C, Lebok P, Dum D, Kind S, Minner S, Izbicki J, Schlomm T, Huland H, Heinzer H, Burandt E, Haese A, Graefen M, Meiners J., Free PMC Article | 02/6/2021 |
| Poly(A) site-dependent deceleration caused by PNUTS-PP1 and Spt5 dephosphorylation is required to convert Pol II into a viable target for the Xrn2 terminator exonuclease, leading to transcription termination. | Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.
Cortazar MA, Sheridan RM, Erickson B, Fong N, Glover-Cutter K, Brannan K, Bentley DL., Free PMC Article | 02/22/2020 |
| PNUTS depletion suppresses the activation of Aurora A/B kinases, and disrupts the spatiotemporal regulation of the chromosomal passenger complex (CPC). PNUTS dynamically localizes to kinetochores, and is required for the activation of the spindle assembly checkpoint. | Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression.
Wang F, Wang L, Fisher LA, Li C, Wang W, Peng A. | 01/25/2020 |
| The work demonstrates that PP1/PNUTS stabilizes chromatin-bound MYC in proliferating cells. | MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.
Dingar D, Tu WB, Resetca D, Lourenco C, Tamachi A, De Melo J, Houlahan KE, Kalkat M, Chan PK, Boutros PC, Raught B, Penn LZ., Free PMC Article | 12/22/2018 |
| A -31 G to A "hot zone" putative functional noncoding variant of PPP1R10 was found in an AML patient. It perturbs the binding activities of E2F1, E2F4, ZBTB33, and TBP. SRSF1 and PPP1R10 genes are interacting partners in a protein-protein interaction network. | Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients.
Min JW, Koh Y, Kim DY, Kim HL, Han JA, Jung YJ, Yoon SS, Choi SS., Free PMC Article | 11/3/2018 |
| PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context. | A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH., Free PMC Article | 10/7/2017 |
| Biophysical analysis of PNUTS suggests an extended transcription factor TFIIS-like fold. | Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold.
Zacharchenko T, Barsukov I, Rigden DJ, Bennett D, Mayans O. | 06/10/2017 |
| PNUTS was a valid target of miR-383 and was involved in the inhibition of gammaH2AX. | microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells.
Huang H, Tian H, Duan Z, Cao Y, Zhang XS, Sun F. | 11/8/2014 |
| PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, especially retinoblastoma protein, by blocking their binding sites on PP1. | Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R., Free PMC Article | 05/31/2014 |
| our studies reveal PNUTS as a novel PTEN regulator and a likely oncogene. | PNUTS functions as a proto-oncogene by sequestering PTEN.
Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S., Free PMC Article | 03/2/2013 |
| PNUTS is identified as a new and integral component of the DNA damage response involved in DNA repair. | The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.
Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T., Free PMC Article | 02/5/2011 |
| stimulation of PP1 activity via siRNA mediated knockdown of its interacting protein PNUTS (Phosphatase Nuclear Targeting Subunit) leads to Rb dephosphorylation and apoptosis in cancer cells | PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.
De Leon G, Cavino M, D'Angelo M, Krucher NA., Free PMC Article | 11/27/2010 |
| mammalian Wdr82 functions in a variety of cellular processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1) has a role in the regulation of chromatin structure during the transition from mitosis into interphase | Identification and characterization of a novel human PP1 phosphatase complex.
Lee JH, You J, Dobrota E, Skalnik DG., Free PMC Article | 09/27/2010 |
| the coordinated spatial and temporal regulation of LCP1 and PNUTS may be a novel mechanism to control the expression of genes that are critical for certain physiological and pathological processes. | Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation.
Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG., Free PMC Article | 01/21/2010 |
| no evidence found of association between a CAT53 polymorphism and Alzheimer's Disease (AD), but found a significant negative association of the C282Y HFE mutation with AD | CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation.
Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G, Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHigh-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation.
Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G, Correia AP, Pinto JP, Dias V, Mascarenhas C, Almeida S, Porto G. | 05/17/2009 |
| reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis | Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis.
De Leon G, Sherry TC, Krucher NA. | 01/21/2010 |
| Findings suggest that PNUTS may play an important role in controlling cell death in response to cellular stresses such as hypoxia through the post-translational modification of p53 and MDM2. | Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.
Lee SJ, Lim CJ, Min JK, Lee JK, Kim YM, Lee JY, Won MH, Kwon YG. | 01/21/2010 |
| PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus | PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.
Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG. | 01/21/2010 |
| PNUTS, encoded by CAT 53 on 6p21.3, may have a role in the progression of AD. | CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease.
Raha-Chowdhury R, Andrews SR, Gruen JR. | 01/21/2010 |
| results illustrate an involvement of the PNUTS:PP1 holoenzyme in chromosome decondensation in vitro and argue that PNUTS functions as a PP1-targeting subunit in this process | PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner.
Landsverk HB, Kirkhus M, Bollen M, Küntziger T, Collas P., Free PMC Article | 01/21/2010 |