| CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival. | CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival.
Dong K, Nihal R, Meyer TJ, Singh SP, Kaur S, Roberts DD., Free PMC Article | 08/31/2024 |
| sequencing of IFT57 in 13 OFDS subjects and 12 subjects with Ellis-Van Creveld syndrome was negative. This report identifies the implication of IFT57 in human pathology and highlights the first description of a ciliary transport defect in OFDS, extending the genetic heterogeneity of this subgroup of ciliopathies. | Autosomal recessive IFT57 hypomorphic mutation cause ciliary transport defect in unclassified oral-facial-digital syndrome with short stature and brachymesophalangia.
Thevenon J, Duplomb L, Phadke S, Eguether T, Saunier A, Avila M, Carmignac V, Bruel AL, St-Onge J, Duffourd Y, Pazour GJ, Franco B, Attie-Bitach T, Masurel-Paulet A, Rivière JB, Cormier-Daire V, Philippe C, Faivre L, Thauvin-Robinet C., Free PMC Article | 07/8/2017 |
| HIPPI-P53 interaction was necessary for HIPPI mediated up-regulation of Caspase1 gene. | Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validation.
Datta M, Choudhury A, Lahiri A, Bhattacharyya NP., Free PMC Article | 02/11/2012 |
| novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease. | Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).
Datta M, Bhattacharyya NP., Free PMC Article | 11/26/2011 |
| Over-expression of BLOC1S2 in presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 & HIPPI sensitize NCH89 glioblastoma cells to pro-apoptotic actions of staurosporine & death ligand TRAIL. | BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Gdynia G, Lehmann-Koch J, Sieber S, Tagscherer KE, Fassl A, Zentgraf H, Matsuzawa S, Reed JC, Roth W. | 01/21/2010 |
| Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway. | Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW. | 01/21/2010 |
| In summary, we showed that HIPPI could interact with the putative promoter sequence of caspase-1 and increased the expression of the downstream gene suggesting that HIPPI could act as transcription regulator. | Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo.
Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP. | 01/21/2010 |
| Hippi interacts with the viral death protein Apoptin. | The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1.
Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY. | 01/21/2010 |
| critical for the death-promoting effects of mutant huntingtin protein in cultured cells | Accomplices to neuronal death.
Mattson MP. | 01/21/2010 |
| Hippi expression induced apoptosis by releasing AIF and cytochrome c from mitochondria, activation of caspase-1 and caspase-3, and altering the expression of apoptotic genes and genes involved in mitochondrial complex I and II. | Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1.
Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP. | 01/21/2010 |
| Crystals of the pDED of HIPPI were grown in space group P4(1), with unit-cell parameters a = b = 77.42, c = 33.31 A and a calculated Matthews coefficient of 1.88 A3 Da(-1) (33% solvent content) with two molecules per asymmetric unit. | Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1.
Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U., Free PMC Article | 01/21/2010 |