| Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes. | Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes.
Chen W, Wang F, Zeng W, Zhang X, Shen L, Zhang Y, Zhou X., Free PMC Article | 11/5/2022 |
| An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20. | An association study in the Taiwan Biobank elicits three novel candidates for cognitive aging in old adults: NCAM1, TTC12 and ZBTB20.
Lin E, Kuo PH, Lin WY, Liu YL, Yang AC, Tsai SJ., Free PMC Article | 12/11/2021 |
| TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella. | TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella.
Thomas L, Bouhouche K, Whitfield M, Thouvenin G, Coste A, Louis B, Szymanski C, Bequignon E, Papon JF, Castelli M, Lemullois M, Dhalluin X, Drouin-Garraud V, Montantin G, Tissier S, Duquesnoy P, Copin B, Dastot F, Couvet S, Barbotin AL, Faucon C, Honore I, Maitre B, Beydon N, Tamalet A, Rives N, Koll F, Escudier E, Tassin AM, Touré A, Mitchell V, Amselem S, Legendre M., Free PMC Article | 04/18/2020 |
| Meta-analysis found that the minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking and higher plasma cotinine levels. This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent response during reward anticipation and with higher DRD2 gene expression in the striatum, but not with TTC12 or ANKK gene expression. | A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.
Macare C, Ducci F, Zhang Y, Ruggeri B, Jia T, Kaakinen M, Kalsi G, Charoen P, Casoni F, Peters J, Bromberg U, Hill M, Buxton J, Blakemore A, Veijola J, Büchel C, Banaschewski T, Bokde ALW, Conrod P, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Desrivières S, Munafò M, Järvelin MR, Schumann G, IMAGEN Consortium., Free PMC Article | 06/8/2019 |
| TTC12 SNP rs7130431 was associated with heroin dependence. | ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.
Nelson EC, Lynskey MT, Heath AC, Wray N, Agrawal A, Shand FL, Henders AK, Wallace L, Todorov AA, Schrage AJ, Saccone NL, Madden PA, Degenhardt L, Martin NG, Montgomery GW., Free PMC Article | 05/4/2013 |
| TTC12-ANKK1-DRD2s seemed to influence smoking behavior mainly in adolescence, and its effect is partially mediated by personality characteristics promoting drug-seeking behavior. | TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.
Ducci F, Kaakinen M, Pouta A, Hartikainen AL, Veijola J, Isohanni M, Charoen P, Coin L, Hoggart C, Ekelund J, Peltonen L, Freimer N, Elliott P, Schumann G, Järvelin MR., Free PMC Article | 07/2/2011 |
| This study evaluated the interaction of ANKK1, TTC12, sex, and continental ancestry in tobacco smokers. | Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans.
David SP, Mezuk B, Zandi PP, Strong D, Anthony JC, Niaura R, Uhl GR, Eaton WW, David SP, Mezuk B, Zandi PP, Strong D, Anthony JC, Niaura R, Uhl GR, Eaton WW., Free PMC Articles: PMC2825103, PMC2825103 | 05/31/2010 |
| Genetic linkage tests conclude that variants in TTC12 exon 3 are involved in the regulation of risk for comorbid alcohol and drug dependence. | Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.
Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J, Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J., Free PMC Articles: PMC2975565, PMC2975565 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesSex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans.
David SP, Mezuk B, Zandi PP, Strong D, Anthony JC, Niaura R, Uhl GR, Eaton WW, David SP, Mezuk B, Zandi PP, Strong D, Anthony JC, Niaura R, Uhl GR, Eaton WW. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.
Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J, Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.
Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J, Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.
Gelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, Farrer L. | 03/13/2008 |
| association studies of alcohol dependence and 43 SNPs mapped to the gene cluster of NCAM1, TTC12, ANKK1 and DRD2 | Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.
Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J, Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. | 01/21/2010 |
| the TTC12 gene is hypermethylated in acute lymphoblastic leukemia | Hypermethylation of TTC12 gene in acute lymphoblastic leukemia.
Wattanawaraporn R, Singhsilarak T, Nuchprayoon I, Mutirangura A. | 01/21/2010 |