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    ALKBH5 alkB homolog 5, RNA demethylase [ Homo sapiens (human) ]

    Gene ID: 54890, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/beta-catenin activation.

    ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation.
    Liang Z, Huang T, Li W, Ma Z, Wang K, Zhai Z, Fan Y, Fu Y, Wang X, Qin Y, Wang B, Zhao C, Kuang J, Pei D., Free PMC Article

    11/5/2024
    ALKBH5 Regulates Osteogenic Differentiation via the lncRNA/mRNA Complex.

    ALKBH5 Regulates Osteogenic Differentiation via the lncRNA/mRNA Complex.
    Song Y, Gao H, Pan Y, Gu Y, Sun W, Wang Y, Liu J.

    10/31/2024
    ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation.

    ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation.
    Wang W, Li H, Qian Y, Li M, Deng M, Bi D, Zou J., Free PMC Article

    10/31/2024
    ALKBH5 promotes hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expression.

    ALKBH5 promotes hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expression.
    Chang Q, Zhou X, Mao H, Feng J, Wu X, Zhang Z, Hu Z., Free PMC Article

    10/28/2024
    ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction.

    ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction.
    Qin C, Wu J, Wei X, Liu X, Lin Y., Free PMC Article

    10/25/2024
    ALKBH5 facilitates the progression of infantile hemangioma by increasing FOXF1 expression in a m[6]A-YTHDF2 dependent manner to activate HK-2 signaling.

    ALKBH5 facilitates the progression of infantile hemangioma by increasing FOXF1 expression in a m(6)A-YTHDF2 dependent manner to activate HK-2 signaling.
    Peng K, Xia RP, Zhao F, Xiao Y, Ma TD, Li M, Feng Y, Zhou CG.

    10/16/2024
    N[6]-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression.

    N(6)-methyladenosine demethylase ALKBH5 suppresses malignancy of esophageal cancer by regulating microRNA biogenesis and RAI1 expression.
    Chen P, Li S, Zhang K, Zhao R, Cui J, Zhou W, Liu Y, Zhang L, Cheng Y.

    07/28/2024
    Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity.

    Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity.
    Mao L, Wang L, Lyu Y, Zhuang Q, Li Z, Zhang J, Gu Z, Lu S, Wang X, Guan Y, Xiong J, Wang Y, Mao Y, Yang H, Liu Y., Free PMC Article

    07/18/2024
    ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p.

    ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p.
    Wang S, Zhu X, Hao Y, Su TT, Shi W., Free PMC Article

    07/16/2024
    ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages.

    ALKBH5 promotes non-small cell lung cancer progression and susceptibility to anti-PD-L1 therapy by modulating interactions between tumor and macrophages.
    Hua X, Xu Q, Wu R, Sun W, Gu Y, Zhu S, Liu X, Lv T, Song Y., Free PMC Article

    06/26/2024
    High expression of AlkB homolog 5 suppresses the progression of non-small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11.

    High expression of AlkB homolog 5 suppresses the progression of non-small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11.
    Huang Z, Lin G, Hong Y, Weng L, Zhu K, Zhuang W.

    06/21/2024
    ALKBH5 Modulates Asthma Progression by Downregulating N6-methyladenosine Methylation.

    ALKBH5 Modulates Asthma Progression by Downregulating N6-methyladenosine Methylation.
    Fan X, Wei C, Han Y.

    06/5/2024
    A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.

    A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
    Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X.

    05/23/2024
    ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer.

    ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer.
    An Y, Duan H., Free PMC Article

    04/25/2024
    Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H.

    Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H.
    Fan D, Geng Q, Wang B, Wang X, Xia Y, Yang L, Zhang Q, Deng T, Xu Y, Zhao H, Liu B, Lu C, Gu X, Xiao C.

    03/18/2024
    ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m[6]A-dependent manner.

    ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m(6)A-dependent manner.
    Wang H, Zhao S, Liu H, Liu Y, Zhang Z, Zhou Z, Wang P, Qi S, Xie J., Free PMC Article

    03/15/2024
    ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT.

    ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting CEMIP-mediated EMT.
    Gao L, Qiao L, Li Y, Jia L, Cui W, Yang J, Wu C, Wang L.

    02/20/2024
    ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA.

    ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA.
    Zhao X, Zhao Z, Xie H, Gao W, Ye C.

    02/7/2024
    The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.

    The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
    Tsukuda S, Harris JM, Magri A, Balfe P, Siddiqui A, Wing PAC, McKeating JA., Free PMC Article

    02/6/2024
    M[6]A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer.

    M(6)A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer.
    Liu X, Li P, Huang Y, Li H, Liu X, Du Y, Lin X, Chen D, Liu H, Zhou Y., Free PMC Article

    02/2/2024
    Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.

    Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis.
    He L, Liu L, Xu D, Tu Y, Yang C, Zhang M, Wang H, Nong X.

    02/1/2024
    The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.

    The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.
    Liu Y, Wang S, Wei S, Qiu X, Mei Y, Yan L., Free PMC Article

    02/1/2024
    ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma.

    ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma.
    Fan Y, Yan D, Ma L, Liu X, Luo G, Hu Y, Kou X., Free PMC Article

    01/17/2024
    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.

    EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
    Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN., Free PMC Article

    01/9/2024
    ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.

    ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.
    Tan J, Chen F, Wang J, Li J, Ouyang B, Li X, Li Y, Zhang W, Jiang Y.

    01/8/2024
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