| Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification. | Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification.
Alesutan I, Razazian M, Luong TTD, Estepa M, Pitigala L, Henze LA, Obereigner J, Mitter G, Zickler D, Schuchardt M, Deisl C, Makridakis M, Gollmann-Tepeköylü C, Pasch A, Cejka D, Suessner S, Antlanger M, Bielesz B, Müller M, Vlahou A, Holfeld J, Eckardt KU, Voelkl J. | 09/30/2024 |
| Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling. | Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling.
Bodega-Mayor I, Delgado-Wicke P, Arrabal A, Alegría-Carrasco E, Nicolao-Gómez A, Jaén-Castaño M, Espadas C, Dopazo A, de Luis EV, Martín-Gayo E, Gaspar ML, de Andrés B, Fernández-Ruiz E., Free PMC Article | 05/24/2024 |
| TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis. | TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.
Gracey E, Hromadová D, Lim M, Qaiyum Z, Zeng M, Yao Y, Srinath A, Baglaenko Y, Yeremenko N, Westlin W, Masse C, Müller M, Strobl B, Miao W, Inman RD., Free PMC Article | 01/2/2021 |
| The study shows that poultry dust controls the induction of immune and inflammatory mediator expression via a cellular pathway involving oxidative stress-mediated STAT3 activation by TYK2 and EGFR tyrosine kinases. | Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.
Natarajan K, Meganathan V, Mitchell C, Boggaram V., Free PMC Article | 03/28/2020 |
| our findings provide the first evidence, to our knowledge, for a key role of TYK2 in the host environment in promoting NK cell maturation and antitumor activity. | NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.
Simonović N, Witalisz-Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, Farlik M, Bock C, Sexl V, Müller M, Strobl B., Free PMC Article | 01/11/2020 |
| TYK2(P) diminishes IL-12, IL-23, and IFN I signaling and that its protective effect is most likely manifest in the setting of autoimmune triggers that concurrently dysregulate at least two of these important signaling cascades. | The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.
Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ., Free PMC Article | 12/14/2019 |
| TYK2 genetic variants are differentially associated with common autoimmune diseases | Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L., Free PMC Article | 12/30/2017 |
| Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN. | Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm.
Yamaji T, Shide K, Kameda T, Sekine M, Kamiunten A, Hidaka T, Kubuki Y, Shimoda H, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Shimoda K. | 08/26/2017 |
| mutated form which lacks tyrosine kinase activity restores differentiation of brown preadipocytes | Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.
Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler JD, Strobl B, Gamero A, Harris TE, Larner AC., Free PMC Article | 06/24/2017 |
| Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus. | Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.
Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S., Free PMC Article | 04/9/2016 |
| Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 signaling to STAT3 | Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
Hainzl E, Stockinger S, Rauch I, Heider S, Berry D, Lassnig C, Schwab C, Rosebrock F, Milinovich G, Schlederer M, Wagner M, Schleper C, Loy A, Urich T, Kenner L, Han X, Decker T, Strobl B, Müller M., Free PMC Article | 02/27/2016 |
| A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3. | Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.
Übel C, Graser A, Koch S, Rieker RJ, Lehr HA, Müller M, Finotto S., Free PMC Article | 10/31/2015 |
| Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis. | Tyk2 is a therapeutic target for psoriasis-like skin inflammation.
Ishizaki M, Muromoto R, Akimoto T, Sekine Y, Kon S, Diwan M, Maeda H, Togi S, Shimoda K, Oritani K, Matsuda T. | 12/20/2014 |
| The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer. | Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.
Vielnascher RM, Hainzl E, Leitner NR, Rammerstorfer M, Popp D, Witalisz A, Rom R, Karaghiosoff M, Kolbe T, Müller S, Rülicke T, Lassnig C, Strobl B, Müller M. | 12/20/2014 |
| In cellular assays, SAR-20347 dose dependently (1 nM-10 muM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-alpha receptors. | Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.
Works MG, Yin F, Yin CC, Yiu Y, Shew K, Tran TT, Dunlap N, Lam J, Mitchell T, Reader J, Stein PL, D'Andrea A., Free PMC Article | 11/22/2014 |
| this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27. | Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
Bosmann M, Strobl B, Kichler N, Rigler D, Grailer JJ, Pache F, Murray PJ, Müller M, Ward PA., Free PMC Article | 09/13/2014 |
| Tyk2-mediated IL-12 signaling is differentially required for the development of different Th1 cell subsets but similarly induces their bystander IFN-gamma production | Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.
Hashiguchi T, Oyamada A, Sakuraba K, Shimoda K, Nakayama KI, Iwamoto Y, Yoshikai Y, Yamada H. | 06/28/2014 |
| Expression of Tyk2 or the constitutively active form of the transcription factor Stat3 (CAStat3) restores differentiation in Tyk2(-/-) brown preadipocytes. | Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.
Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC., Free PMC Article | 05/25/2013 |
| The first mouse Tyk2 crystal structures, which are complexed to 3-aminoindazole compounds, are described. | Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Argiriadi MA, Goedken ER, Banach D, Borhani DW, Burchat A, Dixon RW, Marcotte D, Overmeyer G, Pivorunas V, Sadhukhan R, Sousa S, Moore NS, Tomlinson M, Voss J, Wang L, Wishart N, Woller K, Talanian RV., Free PMC Article | 03/23/2013 |
| The results provide the first evidence for a role of Tyk2 in suppressing the growth and metastasis of breast cancer. | The role of Tyk2 in regulation of breast cancer growth.
Zhang Q, Sturgill JL, Kmieciak M, Szczepanek K, Derecka M, Koebel C, Graham LJ, Dai Y, Chen S, Grant S, Cichy J, Shimoda K, Gamero A, Manjili M, Bear H, Conrad D, Larner AC., Free PMC Article | 06/16/2012 |
| important functions of Tyk2 at the molecular interface between innate immunity and cellular metabolism. | A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).
Grunert T, Leitner NR, Marchetti-Deschmann M, Miller I, Wallner B, Radwan M, Vogl C, Kolbe T, Kratky D, Gemeiner M, Allmaier G, Müller M, Strobl B., Free PMC Article | 03/3/2012 |
| gene deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis | Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
Ishizaki M, Muromoto R, Akimoto T, Ohshiro Y, Takahashi M, Sekine Y, Maeda H, Shimoda K, Oritani K, Matsuda T. | 12/3/2011 |
| The consequent effect of SOCS1 inhibition of Tyk2 not only results in a reduced IFN response because of inhibition of Tyk2 kinase-mediated STAT signaling but also negatively impacts IFNAR1 surface expression, which is stabilized by Tyk2. | Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2.
Piganis RA, De Weerd NA, Gould JA, Schindler CW, Mansell A, Nicholson SE, Hertzog PJ., Free PMC Article | 11/26/2011 |
| A negative regulatory function is found for Tyk2 that controls IL-1ss expression in response to lipopolysaccharide at the level of translation and is probably dependent on canonical type I interferon signaling. | Tyrosine kinase 2 controls IL-1ß production at the translational level.
Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Müller M, Strobl B., Free PMC Article | 11/27/2010 |
| Findings suggest an important regulatory role for Tyk2 in modulating the relationship between immunity and metabolism. | Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.
Vogl C, Flatt T, Fuhrmann B, Hofmann E, Wallner B, Stiefvater R, Kovarik P, Strobl B, Müller M., Free PMC Article | 07/5/2010 |