| High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer. | High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer.
Batbayar C, Ishii N, Harimoto N, Yokobori T, Saito H, Gantumur D, Gombodorj N, Erkhem-Ochir B, Muranushi R, Hoshino K, Yamanaka T, Hagiwara K, Tsukagoshi M, Watanabe A, Araki K, Hosouchi Y, Shirabe K. | 07/4/2023 |
| Depletion of Ebp1 expression in primary colon cancer cells inhibits cell proliferation, colony forming, and invasion in vitro as well as tumor formation in vivo and enhances cell sensitivity to irradiation. We further demonstrated that Ebp1 interacts with TIF-90, a splice variant of transcription initiation factor IA (TIF-IA) of the RNA polymerase I complex. | Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.
Nguyen DQ, Hoang DH, Nguyen TTV, Ho HD, Huynh V, Shin JH, Ly QT, Thi Nguyen DD, Ghoda L, Marcucci G, Nguyen LXT. | 06/13/2020 |
| Specific stress stimuli of NF-kappaB induce degradation of a critical component of the PolI complex, TIF-IA. This degradation precedes activation of NF-kappaB and is associated with increased nucleolar size. | Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.
Chen J, Lobb IT, Morin P, Novo SM, Simpson J, Kennerknecht K, von Kriegsheim A, Batchelor EE, Oakley F, Stark LA., Free PMC Article | 08/3/2019 |
| These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA. | Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.
Nguyen le XT, Mitchell BS., Free PMC Article | 03/1/2014 |
| DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription | DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.
Stepanchick A, Zhi H, Cavanaugh AH, Rothblum K, Schneider DA, Rothblum LI., Free PMC Article | 06/1/2013 |
| reveals the molecular basis of Rrn3-regulated Pol I initiation and cell growth | Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.
Blattner C, Jennebach S, Herzog F, Mayer A, Cheung AC, Witte G, Lorenzen K, Hopfner KP, Heck AJ, Aebersold R, Cramer P., Free PMC Article | 12/3/2011 |
| CK2 phosphorylates the transcription initiation factor TIF-IA at serines 170 and 172 (Ser170/172), and this phosphorylation triggers the release of TIF-IA from Pol I after transcription initiation. | Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.
Bierhoff H, Dundr M, Michels AA, Grummt I., Free PMC Article | 01/21/2010 |
| The definition of the Alu element within the TIF-IA gene as an exon is restricted to certain types of cancers; the element is not exonized in normal human cells. | Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.
Amit M, Sela N, Keren H, Melamed Z, Muler I, Shomron N, Izraeli S, Ast G., Free PMC Article | 01/21/2010 |
| Phosphorylation of S44 activates and S199 inactivates TIF-IA. | mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.
Mayer C, Zhao J, Yuan X, Grummt I., Free PMC Article | 01/21/2010 |
| ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. | ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.
Zhao J, Yuan X, Frödin M, Grummt I. | 01/21/2010 |
| Data show that nutrient starvation, density arrest and protein synthesis inhibitors inactivate transcription initiation factor-IA and impair its association with RNA polymerase I. | Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.
Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I., Free PMC Article | 01/21/2010 |