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    PPARD peroxisome proliferator activated receptor delta [ Homo sapiens (human) ]

    Gene ID: 5467, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Activation of PPARdelta in bone marrow endothelial progenitor cells improves their hematopoiesis-supporting ability after myelosuppressive injury.

    Activation of PPARδ in bone marrow endothelial progenitor cells improves their hematopoiesis-supporting ability after myelosuppressive injury.
    Liang M, Lyu ZS, Zhang YY, Tang SQ, Xing T, Chen YH, Wang Y, Jiang Q, Xu LP, Zhang XH, Huang XJ, Kong Y.

    06/8/2024
    Clinical Relevance of Differential RARalpha and PPARbeta/delta Expression in Myelodysplastic Syndromes.

    Clinical Relevance of Differential RARα and PPARβ/δ Expression in Myelodysplastic Syndromes.
    Kalitin N, Dudina G, Kostritsa N, Sivirinova A, Vaiman A, Karamysheva A., Free PMC Article

    03/1/2024
    Peroxisome proliferator-activated receptor delta improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching.

    Peroxisome proliferator-activated receptor δ improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching.
    Lien CF, Lin CS, Shyue SK, Hsieh PS, Chen SJ, Lin YT, Chien S, Tsai MC.

    07/19/2023
    C Allele of the PPARdelta+294T>C Polymorphism Confers a Higher Risk of Hypercholesterolemia, but not Obesity and Insulin Resistance: A Systematic Review and Meta-Analysis.

    C Allele of the PPARδ+294T>C Polymorphism Confers a Higher Risk of Hypercholesterolemia, but not Obesity and Insulin Resistance: A Systematic Review and Meta-Analysis.
    Li S, Zhang Y, Xu W, Lv Z, Xu L, Zhao Z, Zhu D, Song Y.

    05/5/2023
    Haplotype of ESR1 and PPARD Genes Is Associated with Higher Anthropometric Changes in Han Chinese Obesity by Adjusting Dietary Factors-An 18-Month Follow-Up.

    Haplotype of ESR1 and PPARD Genes Is Associated with Higher Anthropometric Changes in Han Chinese Obesity by Adjusting Dietary Factors-An 18-Month Follow-Up.
    Huang YM, Wang W, Hsieh PP, Chen HH., Free PMC Article

    11/5/2022
    miR-24-3p obstructs the proliferation and migration of human skin fibroblasts after thermal injury by targeting PPAR-beta and positively regulated by NF-kappaB.

    miR-24-3p obstructs the proliferation and migration of human skin fibroblasts after thermal injury by targeting PPAR-β and positively regulated by NF-κB.
    Cui X, Huang X, Huang M, Zhou S, Le G, Yu W, Duan M, Jiang B, Zeng J, Zhou J, Huang X, Liang P, Zhang P.

    06/18/2022
    Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARdelta.

    Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ.
    Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I., Free PMC Article

    05/21/2022
    Unraveling Gut Microbiota Signatures Associated with PPARD and PARGC1A Genetic Polymorphisms in a Healthy Population.

    Unraveling Gut Microbiota Signatures Associated with PPARD and PARGC1A Genetic Polymorphisms in a Healthy Population.
    Bailén M, Tabone M, Bressa C, Lominchar MGM, Larrosa M, González-Soltero R., Free PMC Article

    04/30/2022
    PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

    PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.
    Wickramasinghe NM, Sachs D, Shewale B, Gonzalez DM, Dhanan-Krishnan P, Torre D, LaMarca E, Raimo S, Dariolli R, Serasinghe MN, Mayourian J, Sebra R, Beaumont K, Iyengar S, French DL, Hansen A, Eschenhagen T, Chipuk JE, Sobie EA, Jacobs A, Akbarian S, Ischiropoulos H, Ma'ayan A, Houten SM, Costa K, Dubois NC., Free PMC Article

    04/23/2022
    Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor delta in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative.

    Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative.
    Oyama T, Takiguchi K, Miyachi H., Free PMC Article

    03/26/2022
    PPARD rs2016520 (T/C) and NOS1AP rs12742393 (A/C) polymorphisms affect therapeutic efficacy of nateglinide in Chinese patients with type 2 diabetes mellitus.

    PPARD rs2016520 (T/C) and NOS1AP rs12742393 (A/C) polymorphisms affect therapeutic efficacy of nateglinide in Chinese patients with type 2 diabetes mellitus.
    Wang T, Song JF, Zhou XY, Li CL, Yin XX, Lu Q., Free PMC Article

    03/5/2022
    Peroxisome proliferator-activated receptor-delta-mediated upregulation of catalase helps to reduce ultraviolet B-induced cellular injury in dermal fibroblasts.

    Peroxisome proliferator-activated receptor-δ-mediated upregulation of catalase helps to reduce ultraviolet B-induced cellular injury in dermal fibroblasts.
    Hur J, Kang ES, Hwang JS, Lee WJ, Won JP, Lee HG, Kim E, Seo HG.

    02/26/2022
    Exploration of novel candidate genes involved in epidermal keratinocyte differentiation and skin barrier repair in man.

    Exploration of novel candidate genes involved in epidermal keratinocyte differentiation and skin barrier repair in man.
    Zhang H, Weström S, Kappelin P, Virtanen M, Vahlquist A, Törmä H.

    01/1/2022
    N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.

    N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
    Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z., Free PMC Article

    12/25/2021
    Recent Insights on the Role of PPAR-beta/delta in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy.

    Recent Insights on the Role of PPAR-β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy.
    Strosznajder AK, Wójtowicz S, Jeżyna MJ, Sun GY, Strosznajder JB., Free PMC Article

    11/27/2021
    Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study.

    Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study.
    Kobayashi S, Sata F, Goudarzi H, Araki A, Miyashita C, Sasaki S, Okada E, Iwasaki Y, Nakajima T, Kishi R., Free PMC Article

    11/6/2021
    MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor beta.

    MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β.
    Chai CY, Tai IC, Zhou R, Song J, Zhang C, Sun S., Free PMC Article

    10/16/2021
    VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment.

    VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment.
    Hu PS, Li T, Lin JF, Qiu MZ, Wang DS, Liu ZX, Chen ZH, Yang LP, Zhang XL, Zhao Q, Chen YX, Lu YX, Wu QN, Pu HY, Zeng ZL, Xie D, Ju HQ, Luo HY, Xu RH., Free PMC Article

    10/9/2021
    The PPARbeta/delta-AMPK Connection in the Treatment of Insulin Resistance.

    The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance.
    Aguilar-Recarte D, Palomer X, Wahli W, Vázquez-Carrera M., Free PMC Article

    09/18/2021
    PPARdelta in Affected Atopic Dermatitis and Psoriasis: A Possible Role in Metabolic Reprograming.

    PPARdelta in Affected Atopic Dermatitis and Psoriasis: A Possible Role in Metabolic Reprograming.
    Blunder S, Pavel P, Minzaghi D, Dubrac S., Free PMC Article

    08/21/2021
    Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations.

    Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations.
    Qi YY, Zhai YL, Liu XR, Zhang XX, Zhao YF, Ning XH, Zhao ZZ., Free PMC Article

    05/15/2021
    Wnt/beta-catenin Pathway-Mediated PPARdelta Expression during Embryonic Development Differentiation and Disease.

    Wnt/β-catenin Pathway-Mediated PPARδ Expression during Embryonic Development Differentiation and Disease.
    Sidrat T, Rehman ZU, Joo MD, Lee KL, Kong IK., Free PMC Article

    04/17/2021
    The NFkappaB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases.

    The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases.
    Kung WM, Lin MS., Free PMC Article

    04/3/2021
    Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy.

    Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy.
    Rumiato E, Boldrin E, Malacrida S, Battaglia G, Sileni VC, Ruol A, Amadori A, Saggioro D.

    04/3/2021
    Pro12Ala PPAR-gamma2 and +294T/C PPAR-delta Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.

    Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.
    Carrillo-Venzor MA, Erives-Anchondo NR, Moreno-González JG, Moreno-Brito V, Licón-Trillo A, González-Rodríguez E, Hernández-Rodríguez PDC, Reza-López SA, Loera-Castañeda V, Leal-Berumen I., Free PMC Article

    03/20/2021
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