| The human RAP1 and GFAPvarepsilon proteins increase gamma-secretase activity in a yeast model system. | The human RAP1 and GFAPɛ proteins increase γ-secretase activity in a yeast model system.
Swanson MJ, Lewis KN, Carpenter R, Whetzel A, Bae NS., Free PMC Article | 08/10/2023 |
| Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p. | Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
Li H, Liang J, Wang J, Han J, Li S, Huang K, Liu C., Free PMC Article | 06/15/2023 |
| SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition. | SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition.
Su X, Chen D, Zhu L, Jia H, Cai J, Li P, Han B, Wang D, Li H, Fan J, Gu M, Zhou Y, Guan H, Wei W., Free PMC Article | 04/23/2022 |
| Constitutional variants in POT1, TERF2IP, and ACD genes in patients with melanoma in the Polish population. | Constitutional variants in POT1, TERF2IP, and ACD genes in patients with melanoma in the Polish population.
Malińska K, Deptuła J, Rogoża-Janiszewska E, Górski B, Scott R, Rudnicka H, Kashyap A, Domagała P, Hybiak J, Masojć B, Cybulski C, Kram A, Boer M, Kiedrowicz M, Lubiński J, Dębniak T. | 09/4/2021 |
| Role of telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in colorectal cancer. | Role of telomeric RAP1 in radiation sensitivity modulation and its interaction with CSC marker KLF4 in colorectal cancer.
Anuja K, Kar M, Chowdhury AR, Shankar G, Padhi S, Roy S, Akhter Y, Rath AK, Banerjee B. | 02/20/2021 |
| Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer. | Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer.
Khattar E, Tergaonkar V. | 01/16/2021 |
| Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2. | Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2.
Zhu B, Cao A, Li J, Young J, Wong J, Ashraf S, Bierzynska A, Menon MC, Hou S, Sawyers C, Campbell KN, Saleem MA, He JC, Hildebrandt F, D'Agati VD, Peng W, Kaufman L., Free PMC Article | 10/24/2020 |
| SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway. | SHARPIN Promotes Melanoma Progression via Rap1 Signaling Pathway.
Zhou S, Liang Y, Zhang X, Liao L, Yang Y, Ouyang W, Xu H. | 09/19/2020 |
| miR-1246 mediated H-GDE-induced M2 macrophage polarization by targeting TERF2IP to activate the STAT3 signaling pathway and inhibit the NF-kappaB signaling pathway | Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways.
Qian M, Wang S, Guo X, Wang J, Zhang Z, Qiu W, Gao X, Chen Z, Xu J, Zhao R, Xue H, Li G. | 04/18/2020 |
| We solved the crystal structure of IN-RA-PH to a resolution of 2.4-A. The structure reveals that the IN segment associates with the RA segment and thereby suppresses RIAM:RAP1 association. This autoinhibitory configuration of RIAM can be released by phosphorylation at Tyr45 in the IN segment. | Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.
Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J., Free PMC Article | 05/4/2019 |
| Findings identified eyes absent homolog 4 (EYA4) as a tumor suppressor that disrupts aberrant activation of the nuclear factor kappa B (NF-kappaB)/RAP1 protein signaling pathway and thus orchestrates a physiological impediment to hepatocellular carcinoma (HCC) growth and invasion. | EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation.
Mo SJ, Hou X, Hao XY, Cai JP, Liu X, Chen W, Chen D, Yin XY., Free PMC Article | 03/2/2019 |
| These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma. | EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP.
Rodríguez CI, Castro-Pérez E, Prabhakar K, Block L, Longley BJ, Wisinski JA, Kimple ME, Setaluri V., Free PMC Article | 07/14/2018 |
| Rap1 telomeric and non-telomeric functions and potential implications in diabetic cardiomyopathy have been discussed. (Review) | Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy.
Cai Y, Kandula V, Kosuru R, Ye X, Irwin MG, Xia Z., Free PMC Article | 06/9/2018 |
| the cytoplasmic RAP1-NF-kappaB-BCL2 axis represents a key pathway to cisplatin resistance in non-small cell lung cancer cells. | Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer.
Xiao L, Lan X, Shi X, Zhao K, Wang D, Wang X, Li F, Huang H, Liu J., Free PMC Article | 03/3/2018 |
| Rap1GAP functions as a novel suppressor of epithelial mesenchymal transformation and tumor metastasis in gastric cancer, and loss of Rap1GAP predicts poor prognosis. | Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer.
Yang Y, Zhang J, Yan Y, Cai H, Li M, Sun K, Wang J, Liu X, Wang J, Duan X., Free PMC Article | 03/3/2018 |
| The formation of the Rap1-TRF2 complex restored DNA unwinding. | Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it.
Necasová I, Janoušková E, Klumpler T, Hofr C., Free PMC Article | 12/30/2017 |
| Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI. | Repressor and activator protein accelerates hepatic ischemia reperfusion injury by promoting neutrophil inflammatory response.
Li CX, Lo CM, Lian Q, Ng KT, Liu XB, Ma YY, Qi X, Yeung OW, Tergaonkar V, Yang XX, Liu H, Liu J, Shao Y, Man K., Free PMC Article | 12/16/2017 |
| The Rap1-RIAM-talin axis of integrin activation and blood cell function | The Rap1-RIAM-talin axis of integrin activation and blood cell function.
Lagarrigue F, Kim C, Ginsberg MH., Free PMC Article | 08/5/2017 |
| Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G. | Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP.
Li Y, Dillon TJ, Takahashi M, Earley KT, Stork PJ., Free PMC Article | 05/20/2017 |
| RAP1 promotes colorectal cell migration through the regulation of Vimentin and RAP1 may act as a potential target for the diagnosis and therapy of CRC. | Repressor activator protein 1-promoted colorectal cell migration is associated with the regulation of Vimentin.
Yang Y, Ye C, Wang L, An G, Tian Z, Meng L, Qu L, Lian S, Shou C. | 04/22/2017 |
| Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1. | Heregulin, a new regulator of telomere length in human cells.
Menendez JA, Rubio MA, Campisi J, Lupu R., Free PMC Article | 09/24/2016 |
| Data indicate telomere-binding protein RAP1 as an interacting partner of isoform beta2 of the heregulin (HRGbeta2). | Heregulin, a new interactor of the telosome/shelterin complex in human telomeres.
Menendez JA, Benboudjema L, Vellon L, Rubio MA, Espinoza I, Campisi J, Lupu R., Free PMC Article | 09/24/2016 |
| In pro-inflammatory macrophages, Rap1 promotes cytokine production via NFkappaB activation favoring a pro-inflammatory environment which may contribute to the development and progression of atherosclerosis. | Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions.
Cai Y, Sukhova GK, Wong HK, Xu A, Tergaonkar V, Vanhoutte PM, Tang EH., Free PMC Article | 09/17/2016 |
| Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 and TRF2 | A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
Gaullier G, Miron S, Pisano S, Buisson R, Le Bihan YV, Tellier-Lebègue C, Messaoud W, Roblin P, Guimarães BG, Thai R, Giraud-Panis MJ, Gilson E, Le Du MH., Free PMC Article | 07/30/2016 |
| the conservation of Rap1 reflects its role in transcriptional regulation rather than a function at telomeres. | TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation.
Kabir S, Hockemeyer D, de Lange T., Free PMC Article | 07/25/2015 |