| IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting protein synthesis. | IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting protein synthesis.
Jiang B, Zheng J, Yao H, Wang Y, Song F, Huang C. | 06/18/2024 |
| IRX5 promotes DNA damage repair and activation of hair follicle stem cells. | IRX5 promotes DNA damage repair and activation of hair follicle stem cells.
Chen JK, Wiedemann J, Nguyen L, Lin Z, Tahir M, Hui CC, Plikus MV, Andersen B., Free PMC Article | 05/17/2023 |
| Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities. | Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities.
Son JE, Dou Z, Kim KH, Hui CC. | 10/29/2022 |
| Irx5 and transient outward K(+) currents contribute to transmural contractile heterogeneities in the mouse ventricle. | Irx5 and transient outward K(+) currents contribute to transmural contractile heterogeneities in the mouse ventricle.
Kim KH, Oh Y, Liu J, Dababneh S, Xia Y, Kim RY, Kim DK, Ban K, Husain M, Hui CC, Backx PH. | 04/9/2022 |
| IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mousedagger. | IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†.
Fu A, Koth ML, Brown RM, Shaw SA, Wang L, Krentz KJ, Zhang X, Hui CC, Jorgensen JS., Free PMC Article | 10/16/2021 |
| IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis. | IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis.
Tan Z, Kong M, Wen S, Tsang KY, Niu B, Hartmann C, Chan D, Hui CC, Cheah KSE. | 09/18/2021 |
| Irx3 and Irx5 in Ins2-Cre(+) cells regulate hypothalamic postnatal neurogenesis and leptin response. | Irx3 and Irx5 in Ins2-Cre(+) cells regulate hypothalamic postnatal neurogenesis and leptin response.
Son JE, Dou Z, Kim KH, Wanggou S, Cha VSB, Mo R, Zhang X, Chen X, Ketela T, Li X, Huang X, Hui CC. | 08/7/2021 |
| Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. | Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA., Free PMC Article | 06/19/2021 |
| IRX3/5 regulate mitotic chromatid segregation and limb bud shape. | IRX3/5 regulate mitotic chromatid segregation and limb bud shape.
Tao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC, Hopyan S., Free PMC Article | 04/13/2021 |
| Canonical Wnt/beta-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads. | Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads.
Koth ML, Garcia-Moreno SA, Novak A, Holthusen KA, Kothandapani A, Jiang K, Taketo MM, Nicol B, Yao HH, Futtner CR, Maatouk DM, Jorgensen JS., Free PMC Article | 10/31/2020 |
| Studied role of Iroquois homeobox 5 (Irx5) in adipocytes, amyloid precursor protein, and mitochondrial respiration in obesity mouse models and patients. | IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.
Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G., Free PMC Article | 06/6/2020 |
| Promotion of IRX3 signalling or inhibition of IRX5 signalling could be a route towards differentiation therapy for Wilms tumour, in which WNT5A is a candidate molecule for enforced tubular maturation. | The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.
Holmquist Mengelbier L, Lindell-Munther S, Yasui H, Jansson C, Esfandyari J, Karlsson J, Lau K, Hui CC, Bexell D, Hopyan S, Gisselsson D., Free PMC Article | 12/21/2019 |
| Irx3 and Irx5 first work together to define the pregranulosa cell population of germline nests. During primordial follicle formation, they transition to oocyte- and granulosa cell-specific expression patterns where they cooperate in neighboring cells to build the foundation for follicle integrity. | Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries.
Fu A, Oberholtzer SM, Bagheri-Fam S, Rastetter RH, Holdreith C, Caceres VL, John SV, Shaw SA, Krentz KJ, Zhang X, Hui CC, Wilhelm D, Jorgensen JS., Free PMC Article | 01/19/2019 |
| Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1. | Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.
Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC. | 06/21/2014 |
| postnatal Irx3 activity can be repressed by Irx5 | Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.
Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG., Free PMC Article | 12/22/2012 |
| Iroquois related homeobox 5 (Irx5) transcription factor controls specific aspects of visual function in circuits of the mammalian retina. | Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina.
Kerschensteiner D, Liu H, Cheng CW, Demas J, Cheng SH, Hui CC, Chow RL, Wong RO., Free PMC Article | 01/21/2010 |
| Regulates the development of type 2 and type 3 cone bipolar cells independently of visual system homeobox 1 (Vsx-1). | The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.
Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH. | 01/21/2010 |
| Irx5 establishes the cardiac ventricular repolarization gradient. | The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG., Free PMC Article | 01/21/2010 |