| Study shows that alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty | α6β2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty.
Siciliano CA, McIntosh JM, Jones SR, Ferris MJ., Free PMC Article | 06/16/2018 |
| the mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated. | Molecular simulation study of the unbinding of α-conotoxin [ϒ4E]GID at the α7 and α4β2 neuronal nicotinic acetylcholine receptors.
Suresh A, Hung A. | 02/3/2018 |
| findings indicate that alterations in expression of the alpha4beta2 subtype of nAChR may be involved in the molecular mechanism(s) underlying the cognitive deficit associated with vascular dementia | Inhibited Expression of α(4)β(2) Nicotinic Acetylcholine Receptor in Blood Leukocytes of Chinese Patients with Vascular Dementia and in Blood Leukocytes as Well as the Hippocampus of Brain from Ischemic Rats.
Xiao Y, Zhao L, Kuang SX, Guan ZZ. | 02/25/2017 |
| Data show that although two cholinergic receptor nicotinic beta subunit 2 (beta2 subunit) mutations, F119Q and T59K, strongly enhanced the affinity of alpha-Conotoxin LvIA (LvIA), the beta2 mutation V111I substantially reduced the binding of LvIA. | Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.
Zhangsun D, Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S., Free PMC Article | 06/27/2015 |
| Data indicate that the affinity of alpha-CTxLvIA selectively blocks alpha3beta2 vs. alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors. | A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors.
Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P., Free PMC Article | 06/7/2014 |
| Data indicate that compounds showed favorable subtype selectivity for beta2*-nAChRs over beta4*-nAChRs. | Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP., Free PMC Article | 03/15/2014 |
| Artificial food colors and additives led to an increase in NR2B and nAChR beta2 receptor subunits in male rats and led to decrease in NR2B subunits in female rats. | Effects of maternally exposed coloring food additives on receptor expressions related to learning and memory in rats.
Ceyhan BM, Gultekin F, Doguc DK, Kulac E. | 01/11/2014 |
| Data suggest that alpha4 beta2 nicotinic receptors (Chrna4; Chrnb2) are involved in tolerance to DOPA exhibited as drug-induced dyskinesias in late stages of Parkinson's disease. | α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats.
Quik M, Campos C, Bordia T, Strachan JP, Zhang J, McIntosh JM, Letchworth S, Jordan K., Free PMC Article | 01/11/2014 |
| Positional scanning mutagenesis of alpha-conotoxin PeIA identifies critical residues that confer potency and selectivity for alpha6/alpha3beta2beta3 and alpha3beta2 nicotinic acetylcholine receptors | Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.
Hone AJ, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, McIntosh JM., Free PMC Article | 12/14/2013 |
| alpha4beta2 nicotinic cholineertgic receptor is involved ;in behavioral impairments induced by repeated electroconvulsive seizures in rats. | Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats.
Hidaka N, Suemaru K, Kato Y, Araki H. | 11/30/2013 |
| Data indicate that functional alpha4/beta2 nicotinic acetylcholine receptors (alpha4beta2 nAChR) plays a role in proliferation and differentiation fate into a neuronal lineage in neural progenitors of developing neocortex. | Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors.
Takarada T, Nakamichi N, Kitajima S, Fukumori R, Nakazato R, Le NQ, Kim YH, Fujikawa K, Kou M, Yoneda Y., Free PMC Article | 04/6/2013 |
| The effect of Abeta (at different concentrations) on the neurotransmitter release stimulated by the activation of pre-synaptic cholinergic nicotinic receptors (nAChRs, alpha4beta2 and alpha7 subtypes), is reported. | Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus.
Mura E, Zappettini S, Preda S, Biundo F, Lanni C, Grilli M, Cavallero A, Olivero G, Salamone A, Govoni S, Marchi M., Free PMC Article | 06/2/2012 |
| determined the site specificity for Mor potentiation by studying differences in modulation between alpha3beta2 and alpha4beta2 receptors | Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation.
Cesa LC, Higgins CA, Sando SR, Kuo DW, Levandoski MM., Free PMC Article | 05/5/2012 |
| Nicotine-induced upregulation of the nAChR alpha4beta2 receptor demonstrates that at least two different kinetic mechanisms underlie multiple processes occurring at different rates in rat cortical neurons in real time. | Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms.
Govind AP, Walsh H, Green WN., Free PMC Article | 03/31/2012 |
| Changes in density and affinity of this hippocampal receptor after alcohol drinking. | Ethanol consumption produces changes in behavior and on hippocampal alpha7 and alpha4beta2 nicotinic receptors.
Robles N, Sabriá J. | 10/4/2011 |
| Our study shows for the first time that rat hippocampal synaptosomes possess a7 and a4b2 nAChR subtypes, which can enhance the release of endogenous GLU and ASP via two distinct mechanisms of action | Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms.
Zappettini S, Grilli M, Salamone A, Fedele E, Marchi M., Free PMC Article | 02/26/2011 |
| Data show that a hydrogen bond is functionally significant in the alpha4beta2 neuronal nAChR. | Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.
Blum AP, Lester HA, Dougherty DA., Free PMC Article | 10/4/2010 |
| Suggest a critical role for alpha4beta2 nAChRs in the infralimbic cortex in mediating the effects of nicotine on impulsive-like actions. | Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex.
Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M. | 07/12/2010 |
| Neurexin-1beta targets AChR alpha4 and AChR beta2 to presynaptic terminals. | Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta.
Cheng SB, Amici SA, Ren XQ, McKay SB, Treuil MW, Lindstrom JM, Rao J, Anand R., Free PMC Article | 01/21/2010 |
| These data establish that both beta2* and alpha7 nAChRs can modulate dopamine release in the PFC in vitro and in vivo. | alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex.
Livingstone PD, Srinivasan J, Kew JN, Dawson LA, Gotti C, Moretti M, Shoaib M, Wonnacott S. | 01/21/2010 |
| Phosphorylation at multiple consensus sites in the alpha4 subunit could play a remarkable role on the regulation of the functional expression of the alpha4beta2 nAChR. | Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors.
López-Hernández GY, Biaggi-Labiosa NM, Torres-Cintrón A, Ortiz-Acevedo A, Lasalde-Dominicci JA., Free PMC Article | 01/21/2010 |
| Nicotinic alpha4 beta2 receptors partly mediate brainstem autonomic dysfunction evoked by the inhaled anesthetic isoflurane. | Nicotinic receptors partly mediate brainstem autonomic dysfunction evoked by the inhaled anesthetic isoflurane.
Wang X. | 01/21/2010 |
| Results show that amyloid beta protein induces suppression of long-term potentiation in rat hippocampus, and that this suppression is mediated through alpha4beta2 nicotinic acetylcholine receptors. | Alpha4beta2 nicotinic acetylcholine receptors are required for the amyloid beta protein-induced suppression of long-term potentiation in rat hippocampal CA1 region in vivo.
Wu MN, He YX, Guo F, Qi JS. | 01/21/2010 |
| data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype | Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function.
Perez XA, Bordia T, McIntosh JM, Grady SR, Quik M., Free PMC Article | 01/21/2010 |
| alpha4beta2 nicotinic acetylcholine receptors may play a role in ethanol-seeking behaviors in animals chronically exposed to ethanol | Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.
Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE., Free PMC Article | 01/21/2010 |