| Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation. | Altered conformational dynamics contribute to species-specific effects of cytochrome c mutations on caspase activation.
Chin TC, Wilbanks SM, Ledgerwood EC., Free PMC Article | 08/14/2024 |
| MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma. | MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma.
Olarewaju O, Hu Y, Tsay HC, Yuan Q, Eimterbäumer S, Xie Y, Qin R, Ott M, Sharma AD, Balakrishnan A., Free PMC Article | 07/19/2024 |
| The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells. | The Y49H cytochrome c variant enhances megakaryocytic maturation of K-562 cells.
Shafaei Pishabad Z, Ledgerwood EC. | 05/29/2024 |
| Effects of naturally occurring S47F/A mutations on the structure and function of human cytochrome c. | Effects of naturally occurring S47F/A mutations on the structure and function of human cytochrome c.
Li YY, Long SS, Yu L, Liu AK, Gao SQ, Tan X, Lin YW. | 07/12/2023 |
| The oxidative nuclease activity of human cytochrome c with mutations in Omega-loop C/D. | The oxidative nuclease activity of human cytochrome c with mutations in Ω-loop C/D.
Feng Y, Dong Y, Du KJ, Liu XC, Gao SQ, Lin YW. | 03/16/2023 |
| Influence of cysteine-directed mutations at the Omega-loops on peroxidase activity of human cytochrome c. | Influence of cysteine-directed mutations at the Ω-loops on peroxidase activity of human cytochrome c.
Samsri S, Pornsuwan S. | 12/25/2021 |
| Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging. | Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging.
Kan J, Hu Y, Ge Y, Zhang W, Lu S, Zhao C, Zhang R, Liu Y., Free PMC Article | 12/18/2021 |
| Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis. | Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis.
Bazylianska V, Kalpage HA, Wan J, Vaishnav A, Mahapatra G, Turner AA, Chowdhury DD, Kim K, Morse PT, Lee I, Brunzelle JS, Polin L, Subedi P, Heath EI, Podgorski I, Marcus K, Edwards BFP, Hüttemann M., Free PMC Article | 10/23/2021 |
| Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. | Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity.
Fellner M, Parakra R, McDonald KO, Kass I, Jameson GNL, Wilbanks SM, Ledgerwood EC. | 06/19/2021 |
| VDAC1 Conversely Correlates with Cytc Expression and Predicts Poor Prognosis in Human Breast Cancer Patients. | VDAC1 Conversely Correlates with Cytc Expression and Predicts Poor Prognosis in Human Breast Cancer Patients.
Chen F, Yin S, Luo B, Wu X, Yan H, Yan D, Chen C, Guan F, Yuan J., Free PMC Article | 05/22/2021 |
| Distal Unfolding of Ferricytochrome c Induced by the F82K Mutation. | Distal Unfolding of Ferricytochrome c Induced by the F82K Mutation.
Lalli D, Rosa C, Allegrozzi M, Turano P., Free PMC Article | 01/9/2021 |
| Physical contact between cytochrome c1 and cytochrome c increases the driving force for electron transfer. | Physical contact between cytochrome c(1) and cytochrome c increases the driving force for electron transfer.
Pérez-Mejías G, Olloqui-Sariego JL, Guerra-Castellano A, Díaz-Quintana A, Calvente JJ, Andreu R, De la Rosa MA, Díaz-Moreno I. | 12/5/2020 |
| Comparison of the structural dynamic and mitochondrial electron-transfer properties of the proapoptotic human cytochrome c variants, G41S, Y48H and A51V. | Comparison of the structural dynamic and mitochondrial electron-transfer properties of the proapoptotic human cytochrome c variants, G41S, Y48H and A51V.
Deacon OM, White RW, Moore GR, Wilson MT, Worrall JAR. | 12/5/2020 |
| Spin cascade and doming in ferric hemes: Femtosecond X-ray absorption and X-ray emission studies. | Spin cascade and doming in ferric hemes: Femtosecond X-ray absorption and X-ray emission studies.
Bacellar C, Kinschel D, Mancini GF, Ingle RA, Rouxel J, Cannelli O, Cirelli C, Knopp G, Szlachetko J, Lima FA, Menzi S, Pamfilidis G, Kubicek K, Khakhulin D, Gawelda W, Rodriguez-Fernandez A, Biednov M, Bressler C, Arrell CA, Johnson PJM, Milne CJ, Chergui M., Free PMC Article | 10/31/2020 |
| I81A and V83G variants of human cytochrome c were prepared. These results show that the I81A substitution significantly influences the thermodynamics and kinetics of access to alternate conformers of human cytochrome c, while the V83G substitution has a more modest effect on these properties. | Effect of V83G and I81A Substitutions to Human Cytochrome c on Acid Unfolding and Peroxidase Activity below a Neutral pH.
Lei H, Nold SM, Motta LJ, Bowler BE. | 06/6/2020 |
| Important role for lysine residues of Cyt c and nucleotides in the regulation of apoptosome-dependent apoptotic cell death as well as demonstrate how these mutations and nucleotides may have a pivotal role in human diseases such as cancer. | Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer.
Yadav N, Gogada R, O'Malley J, Gundampati RK, Jayanthi S, Hashmi S, Lella R, Zhang D, Wang J, Kumar R, Suresh Kumar TK, Chandra D., Free PMC Article | 04/25/2020 |
| our study identified three mRNAs (TBX21, TGIF2, and CYCS) that were significantly altered between high- and low-risk patients with breast cancer. The three-mRNA model was independent and predicted the prognosis of patients robustly. Furthermore, this model could predict survival probability precisely in patients with or without metastasis. | Three inflammation-related genes could predict risk in prognosis and metastasis of patients with breast cancer.
Zhao S, Shen W, Du R, Luo X, Yu J, Zhou W, Dong X, Gao R, Wang C, Yang H, Wang S., Free PMC Article | 03/28/2020 |
| This study clearly demonstrates that thrombocytopenia can result from CYCS loss-of-function variants. | A novel CYCS mutation in the α-helix of the CYCS C-terminal domain causes non-syndromic thrombocytopenia.
Uchiyama Y, Yanagisawa K, Kunishima S, Shiina M, Ogawa Y, Nakashima M, Hirato J, Imagawa E, Fujita A, Hamanaka K, Miyatake S, Mitsuhashi S, Takata A, Miyake N, Ogata K, Handa H, Matsumoto N, Mizuguchi T. | 11/16/2019 |
| In this study, site-directed variants at the 41 and 48 positions in the 40-57 Omega-loop and at the 81 and 83 positions in the 71-85 Omega-loop reveal that conformational transitions in the 71-85 Omega-loop, leading to the alkaline or peroxidatic conformers, are controlled by the 40-57 Omega-loop. The variants causing thrombocytopenia, G41S and Y48H, lower the p Ktrigger and increase p Ka2. | Naturally Occurring Disease-Related Mutations in the 40-57 Ω-Loop of Human Cytochrome c Control Triggering of the Alkaline Isomerization.
Deacon OM, Svistunenko DA, Moore GR, Wilson MT, Worrall JAR. | 04/13/2019 |
| Upon positive validation on a larger set of patients, combined quantification of Bcl-2 and cytochrome c might be considered as an adjunct in differential diagnosis of ulcerative colitis and Crohn's disease of colon and rectum | Peripheral Lymphocytes of Patients with Inflammatory Bowel Disease Have Altered Concentrations of Key Apoptosis Players: Preliminary Results.
Neubauer K, Woźniak-Stolarska B, Krzystek-Korpacka M., Free PMC Article | 03/23/2019 |
| Cytochrome c was upregulated in the primary Sjogren's syndrome patients, indicating the potential role of cytochrome c in the pathogenesis and development of primary Sjogren's syndrome. | Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome.
Kang Y, Sun Y, Zhang Y, Wang Z. | 08/4/2018 |
| The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production. | The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.
Kim WS, Lee KS, Kim JH, Kim CK, Lee G, Choe J, Won MH, Kim TH, Jeoung D, Lee H, Kim JY, Ae Jeong M, Ha KS, Kwon YG, Kim YM. | 06/2/2018 |
| This work reveals a direct conformational link between the 40-57 Omega-loop of cytochrome c in which residue 41 resides and the dynamical properties of the axial ligand to the heme iron. | Increased dynamics in the 40-57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation.
Karsisiotis AI, Deacon OM, Wilson MT, Macdonald C, Blumenschein TM, Moore GR, Worrall JA., Free PMC Article | 04/21/2018 |
| The naturally occurring Y48H variant of cytochrome c in its oxidized heme state is more peroxidatic than either the Wild Type protein or the G41S variant that is also implicated in thrombocytopenia. | Heightened Dynamics of the Oxidized Y48H Variant of Human Cytochrome c Increases Its Peroxidatic Activity.
Deacon OM, Karsisiotis AI, Moreno-Chicano T, Hough MA, Macdonald C, Blumenschein TMA, Wilson MT, Moore GR, Worrall JAR. | 12/23/2017 |
| ROCK activation phosphorylated Rac1b at Ser71 and increased reactive oxygen species (ROS) levels by facilitating the interaction between Rac1b and cytochrome c. Conversely, ROCK inactivation abolished their interaction, concomitant with ROS reduction. | Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome.
Kang HT, Park JT, Choi K, Choi HJC, Jung CW, Kim GR, Lee YS, Park SC., Free PMC Article | 12/2/2017 |