| The ARTS of p53-dependent mitochondrial apoptosis. | The ARTS of p53-dependent mitochondrial apoptosis.
Hao Q, Chen J, Lu H, Zhou X., Free PMC Article | 04/14/2023 |
| Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans. | Biallelic loss-of-function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans.
Wang G, Zhu X, Gao Y, Lv M, Li K, Tang D, Wu H, Xu C, Geng H, Shen Q, Zha X, Duan Z, Zhang J, Hua R, Tao F, Zhou P, Wei Z, Cao Y, Guo R, He X. | 12/24/2022 |
| p53 induces ARTS to promote mitochondrial apoptosis. | p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H, Zhou X., Free PMC Article | 09/18/2021 |
| Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury. | Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
Zhang N, Zhang Y, Wu B, You S, Sun Y., Free PMC Article | 04/17/2021 |
| Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonininduced osteoblasts. | Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonin‑induced osteoblasts.
Tao L, Zhao S, Tao Z, Wen K, Zhou S, Da W, Zhu Y., Free PMC Article | 04/17/2021 |
| carnosic acid induces parkin by enhancing the ubiquitination of ARTS, leading to induction of XIAP. | Modulation of ARTS and XIAP by Parkin Is Associated with Carnosic Acid Protects SH-SY5Y Cells against 6-Hydroxydopamine-Induced Apoptosis.
Fu RH, Huang LC, Lin CY, Tsai CW. | 12/22/2018 |
| In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse. | Untangling the Tauopathy for Alzheimer's disease and parkinsonism.
Chang HY, Sang TK, Chiang AS., Free PMC Article | 11/10/2018 |
| Septin4 is a novel essential factor involved in oxidative stress induced vascular endothelial cell injury by interacting with apoptosis-related protein PARP1. | Septin4 as a novel binding partner of PARP1 contributes to oxidative stress induced human umbilical vein endothelial cells injure.
Zhang N, Zhang Y, Zhao S, Sun Y. | 03/10/2018 |
| The data suggest that Sept4_i1 induces hepatic stellate cell apoptosis by inhibiting Akt and Bcl-2 expression and up-regulating PPAR-gamma expression. | Septin4_i1 regulates apoptosis in hepatic stellate cells through peroxisome proliferator-activated receptor-γ/Akt/B-cell lymphoma 2 pathway.
Zhu D, Wang J, Sun X, Chen J, Duan Y, Pan J, Xu T, Qin Y, He X, Huang C., Free PMC Article | 05/2/2015 |
| results suggest that Septin4 may be involved in the process of activation of hepatic stellate cells by lipopolysaccharide stimulation. | Expression of Septin4 in human hepatic stellate cells LX-2 stimulated by LPS.
Sun X, Yang Y, Zhu D, Qian H, Duan Y, He X, Gu X, Sun W, Zhu Y. | 02/15/2014 |
| Bradeion/SEPT4 transcript levels are significantly increased in patients with transitional cell bladder cancer.We hypothesize that Bradeion is directly involved in bladder cancer pathogenesis with the highest expression at early cancer stages. | Bradeion (SEPT4) as a urinary marker of transitional cell bladder cancer: a real-time polymerase chain reaction study of gene expression.
Bongiovanni L, Pirozzi F, Guidi F, Orsini M, Chiurazzi P, Bassi PF, Racioppi M. | 07/13/2013 |
| Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. | Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.
Kim JB, Kim SY, Kim BM, Lee H, Kim I, Yun J, Jo Y, Oh T, Jo Y, Chae HD, Shin DY., Free PMC Article | 06/29/2013 |
| these data suggests a tumor suppressor role of SEPT4_i1 in HCC through regulating hepatocellular carcinoma cell apoptosis. | Involvement of SEPT4_i1 in hepatocellular carcinoma: SEPT4_i1 regulates susceptibility to apoptosis in hepatocellular carcinoma cells.
Shen S, Liu M, Wu Y, Saiyin H, Liu G, Yu L. | 06/30/2012 |
| SEPT4 is a Notch target gene. | SEPT4 is regulated by the Notch signaling pathway.
Liu W. | 06/30/2012 |
| The expression of SEPT4 is significantly decreased in the ejaculated sperm of idiopathic asthenozoospermia patients. | [Expression of SEPT4 protein in the ejaculated sperm of idiopathic asthenozoospermic men].
Li YS, Feng XX, Ji XF, Wang QX, Gao XM, Yang XF, Pan ZH, Sun L, Ma K. | 04/21/2012 |
| ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). | ARTS, the unusual septin: structural and functional aspects.
Mandel-Gutfreund Y, Kosti I, Larisch S. | 01/28/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| structural defects in sperm are not caused by abnormal transcription or point mutations of the TAT1 and SEPT4 genes; however, although both proteins are expressed, they are not properly localized at sperm annulus | Absence of annulus in human asthenozoospermia: case report.
Lhuillier P, Rode B, Escalier D, Lorès P, Dirami T, Bienvenu T, Gacon G, Dulioust E, Touré A. | 01/21/2010 |
| Sporadic PD cases showed a statistically significant decrease of the fold change (FC) of SEPT4 (FC = 0.67, P = 0.054) gene expressions in the substantia nigra & amygdala (SEPT4: FC = 0.32, P = 0.007) versus healthy controls. | Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
Shehadeh L, Mitsi G, Adi N, Bishopric N, Papapetropoulos S. | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| The stability and aggregation properties of the GTPase domain from human SEPT4. | The stability and aggregation properties of the GTPase domain from human SEPT4.
Garcia W, Rodrigues NC, de Oliveira Neto M, de Araújo AP, Polikarpov I, Tanaka M, Tanaka T, Garratt RC. | 01/21/2010 |
| The Sept4 may be involved in PD as a dual susceptibility factor, as its insufficiency can diminish dopaminergic neurotransmission and enhance alpha-synuclein neurotoxicity. | Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.
Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M. | 01/21/2010 |
| This protein may play an important role in the pathogenesis of schizophrenia and could be used as a marker for this disease. | The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients.
Gottfried Y, Rotem A, Klein E, Larisch S. | 01/21/2010 |
| Data report an intermediate structure of the GTPase domain of human SEPT4 (SEPT4-G) during unfolding transitions induced by temperature. | An intermediate structure in the thermal unfolding of the GTPase domain of human septin 4 (SEPT4/Bradeion-beta) forms amyloid-like filaments in vitro.
Garcia W, de Araújo AP, Lara F, Foguel D, Tanaka M, Tanaka T, Garratt RC. | 01/21/2010 |
| SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling | SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K. | 01/21/2010 |