| Myosin 18Aalpha targets the guanine nucleotide exchange factor beta-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation. | Myosin 18Aα targets the guanine nucleotide exchange factor β-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.
Alexander CJ, Barzik M, Fujiwara I, Remmert K, Wang YX, Petralia RS, Friedman TB, Hammer JA., Free PMC Article | 06/19/2021 |
| Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, betaPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice. | Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.
Cheng K, Larabee SM, Tolaymat M, Hanscom M, Shang AC, Schledwitz A, Hu S, Drachenberg CB, Zhan M, Chahdi A, Raufman JP., Free PMC Article | 05/15/2021 |
| ARHGEF7 (beta-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function. | ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.
Matsuda J, Maier M, Aoudjit L, Baldwin C, Takano T., Free PMC Article | 01/2/2021 |
| beta-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo. | β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo.
Omelchenko T, Hall A, Anderson KV., Free PMC Article | 12/12/2020 |
| Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and betaPIX. | Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.
Rajah A, Boudreau CG, Ilie A, Wee TL, Tang K, Borisov AZ, Orlowski J, Brown CM., Free PMC Article | 11/21/2020 |
| GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling. | GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Zhu J, Zhou Q, Xia Y, Lin L, Li J, Peng M, Zhang R, Zhang M. | 09/26/2020 |
| These results indicate that betaPix is required for neurite morphogenesis and synapse formation, and the reduced expression of betaPix proteins results in a defect in social behavior. | βPix heterozygous mice have defects in neuronal morphology and social interaction.
Kwon Y, Lee SJ, Lee E, Kim D, Park D. | 06/6/2020 |
| betaPix-knockout Mouse Embryonic Fibroblasts exhibit decreased Rac1 activity, and defects in cell spreading and platelet-derived growth factor (PDGF)-induced ruffle formation and chemotaxis. | Loss of ϐPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts.
Kang T, Lee SJ, Kwon Y, Park D., Free PMC Article | 01/11/2020 |
| The authors show that Arhgef7 interacts with the GTPase TC10 that is closely related to Cdc42. Expression of active TC10 can restore the ability to extend axons in Arhgef7-deficient neurons | The guanine nucleotide exchange factor Arhgef7/βPix promotes axon formation upstream of TC10.
López Tobón A, Suresh M, Jin J, Vitriolo A, Pietralla T, Tedford K, Bossenz M, Mahnken K, Kiefer F, Testa G, Fischer KD, Püschel AW., Free PMC Article | 10/19/2019 |
| These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation. | β(1)Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells.
Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR., Free PMC Article | 02/9/2019 |
| Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7. | Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR., Free PMC Article | 11/7/2015 |
| It provides for the first time, to our knowledge, a possible mechanism for the concerted action of tyrosine kinases, GIT1/betaPIX proteins, and Ca(2+) in the propagation of signals leading to the regulation of microtubule nucleation in activated mast cells. | Microtubule nucleation in mouse bone marrow-derived mast cells is regulated by the concerted action of GIT1/βPIX proteins and calcium.
Sulimenko V, Hájková Z, Černohorská M, Sulimenko T, Sládková V, Dráberová L, Vinopal S, Dráberová E, Dráber P. | 07/25/2015 |
| beta-Pix controls the spatial localization of Rac1 activity to drive collective AVE migration at a critical stage in mouse development. | β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo.
Omelchenko T, Rabadan MA, Hernández-Martínez R, Grego-Bessa J, Anderson KV, Hall A., Free PMC Article | 02/14/2015 |
| Therefore, we propose that PKCgamma positively modulates dopamine release through beta2PIX phosphorylation. | The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release.
Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, Saito N., Free PMC Article | 09/13/2014 |
| Glucose stimulates Cav-1 and induces its dissociation from Cdc42, to promote Cdc42-betaPix binding and Cdc42 activation, and to trigger downstream signaling and ultimately sustain insulin release. | Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.
Kepner EM, Yoder SM, Oh E, Kalwat MA, Wang Z, Quilliam LA, Thurmond DC., Free PMC Article | 01/28/2012 |
| a model by which SNX27 regulates trafficking of beta-Pix to focal adhesions and thereby influences cell motility. | Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.
Valdes JL, Tang J, McDermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP., Free PMC Article | 12/31/2011 |
| betaPix-b(L) induced pinocytosis through cooperative action of the CH and Dbl homology (DH) domains, demonstrating the role of betaPix-b(L) in the regulation of membrane dynamics | Interaction of microtubules and actin with the N-terminus of βPix-b(L) directs cellular pinocytosis.
Lee SJ, Yang SJ, Kim DH, Pak JH, Lee KH, Choi KH, Park D, Rhee S. | 08/27/2011 |
| Stat3 binds to betaPIX, a Rac1 activator,and regulates Rac1 activity to modulate the organization of actin cytoskeleton and directional migration | Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX.
Teng TS, Lin B, Manser E, Ng DC, Cao X. | 07/26/2010 |
| phosphorylation-dephosphorylation cycle of Cool-1 at Tyr-442 can serve as a key regulatory signal for focal complex assembly-disassembly, and consequently, for the migration and invasive activity of Src-transformed | Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.
Feng Q, Baird D, Yoo S, Antonyak M, Cerione RA., Free PMC Article | 07/5/2010 |
| These results show that the interaction between Abi-1 and betaPIX is involved in the formation of growth factor-induced membrane dorsal ruffles. | A new interaction between Abi-1 and betaPIX involved in PDGF-activated actin cytoskeleton reorganisation.
Campa F, Machuy N, Klein A, Rudel T. | 01/21/2010 |
| Results suggest that the PAK-PIX-GIT1 complex is critical for Erk-dependent myosin phosphorylation and vascular permeability. | Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.
Stockton R, Reutershan J, Scott D, Sanders J, Ley K, Schwartz MA., Free PMC Article | 01/21/2010 |
| The association of PLCgamma1 with complexes containing GIT1 and beta-Pix is essential for its role in integrin-mediated cell spreading and motility. As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1. | Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.
Jones NP, Katan M., Free PMC Article | 01/21/2010 |
| P85 beta-PIX, located downstream of Rac1, is a key regulator for the activations of FAK or p38 MAP kinase and plays a pivotal role in focal complex formation and cell motility. | p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.
Lee J, Jung ID, Chang WK, Park CG, Cho DY, Shin EY, Seo DW, Kim YK, Lee HW, Han JW, Lee HY. | 01/21/2010 |
| the regulated phosphorylation of Cool-1 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation. | Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.
Feng Q, Baird D, Peng X, Wang J, Ly T, Guan JL, Cerione RA. | 01/21/2010 |