| Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains. | Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains.
Wang T, Wang Y, Montero-Pedrazuela A, Prensa L, Guadaño-Ferraz A, Rausell E., Free PMC Article | 06/15/2023 |
| Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Pyramidal Neurons and Interneurons in the Adult Motor Cortex of Human and Macaque Brain. | Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Pyramidal Neurons and Interneurons in the Adult Motor Cortex of Human and Macaque Brain.
Wang Y, Wang T, Montero-Pedrazuela A, Guadaño-Ferraz A, Rausell E., Free PMC Article | 03/1/2023 |
| Single nucleotide polymorphisms in ADAM17, IL23R and SLCO1C1 genes protect against infliximab failure in adults with Crohn's disease. | Single nucleotide polymorphisms in ADAM17, IL23R and SLCO1C1 genes protect against infliximab failure in adults with Crohn's disease.
Laserna-Mendieta EJ, Salvador-Martín S, Arias A, López-Cauce B, Marín-Jiménez I, Menchén LA, Marín-Rubio L, Ontañón Rodríguez J, López-Fernández LA, Lucendo AJ. | 02/25/2023 |
| Deiodinases, organic anion transporter polypeptide polymorphisms and symptoms of anxiety and depression after ischemic stroke. | Deiodinases, organic anion transporter polypeptide polymorphisms and symptoms of anxiety and depression after ischemic stroke.
Taroza S, Rastenytė D, Burkauskas J, Podlipskytė A, Kažukauskienė N, Patamsytė V, Mickuvienė N. | 11/21/2020 |
| Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes. | Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes.
Taroza S, Rastenytė D, Podlipskytė A, Patamsytė V, Mickuvienė N. | 09/19/2020 |
| The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF response in a large UK rheumatoid arthritis cohort. | Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.
Smith SL, Plant D, Lee XH, Massey J, Hyrich K, Morgan AW, Wilson AG, Isaacs J, Barton A., Free PMC Article | 04/1/2017 |
| We found a highly significant association between PDE3A-SLCO1C1 and the clinical response to TNF blockers | Association of the PDE3A-SLCO1C1 locus with the response to anti-TNF agents in psoriasis.
Julià A, Ferrándiz C, Dauden E, Fonseca E, Fernández-López E, Sanchez-Carazo JL, Vanaclocha F, Puig L, Moreno-Ramírez D, Lopez-Estebaranz JL, Herrera E, de la Cueva P, Ávila G, Alonso A, Tortosa R, López-Lasanta M, Marsal S. | 04/23/2016 |
| The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response. | GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis.
Acosta-Colman I, Palau N, Tornero J, Fernández-Nebro A, Blanco F, González-Alvaro I, Cañete JD, Maymó J, Ballina J, Fernández-Gutiérrez B, Olivé A, Corominas H, Erra A, Canela-Xandri O, Alonso A, López Lasanta M, Tortosa R, Julià A, Marsal S. | 03/29/2014 |
| Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar. | The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.
Chan SY, Martín-Santos A, Loubière LS, González AM, Stieger B, Logan A, McCabe CJ, Franklyn JA, Kilby MD., Free PMC Article | 10/8/2011 |
| The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis. | Expression of thyroid hormone transporters in the human hypothalamus.
Alkemade A, Friesema EC, Kalsbeek A, Swaab DF, Visser TJ, Fliers E. | 08/6/2011 |
| OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy. | Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients.
van der Deure WM, Appelhof BC, Peeters RP, Wiersinga WM, Wekking EM, Huyser J, Schene AH, Tijssen JG, Hoogendijk WJ, Visser TJ, Fliers E, van der Deure WM, Appelhof BC, Peeters RP, Wiersinga WM, Wekking EM, Huyser J, Schene AH, Tijssen JG, Hoogendijk WJ, Visser TJ, Fliers E. | 01/21/2010 |
| Protein is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. | Pharmacogenetics of the organic anion transporting polypeptide 1A2.
Franke RM, Scherkenbach LA, Sparreboom A., Free PMC Article | 01/21/2010 |
| OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels. | Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.
Roberts LM, Woodford K, Zhou M, Black DS, Haggerty JE, Tate EH, Grindstaff KK, Mengesha W, Raman C, Zerangue N. | 01/21/2010 |
| OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation | Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation.
van der Deure WM, Hansen PS, Peeters RP, Kyvik KO, Friesema EC, Hegedüs L, Visser TJ, van der Deure WM, Hansen PS, Peeters RP, Kyvik KO, Friesema EC, Hegedüs L, Visser TJ. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation.
van der Deure WM, Hansen PS, Peeters RP, Kyvik KO, Friesema EC, Hegedüs L, Visser TJ, van der Deure WM, Hansen PS, Peeters RP, Kyvik KO, Friesema EC, Hegedüs L, Visser TJ. | 07/2/2008 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients.
van der Deure WM, Appelhof BC, Peeters RP, Wiersinga WM, Wekking EM, Huyser J, Schene AH, Tijssen JG, Hoogendijk WJ, Visser TJ, Fliers E, van der Deure WM, Appelhof BC, Peeters RP, Wiersinga WM, Wekking EM, Huyser J, Schene AH, Tijssen JG, Hoogendijk WJ, Visser TJ, Fliers E. | 04/23/2008 |
| We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis. | Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.
Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. | 01/21/2010 |