| Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity. | Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.
Wu X, Yang ZH, Wu J, Han J. | 05/28/2023 |
| Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. | Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets.
Mills EW, Wangen J, Green R, Ingolia NT., Free PMC Article | 11/18/2017 |
| The data suggest that the decay of platelet mRNAs is slowed by the natural loss of the mRNA surveillance and ribosome rescue factor Pelota. | Slowed decay of mRNAs enhances platelet specific translation.
Mills EW, Green R, Ingolia NT., Free PMC Article | 08/12/2017 |
| Human Pelota compensated for Dom34 functions in quality control of nonstop mRNA in yeast. | Conserved functions of human Pelota in mRNA quality control of nonstop mRNA.
Ikeuchi K, Yazaki E, Kudo K, Inada T. | 05/13/2017 |
| PELO is a novel regulator of HER-signalling. | PELO negatively regulates HER receptor signalling and metastasis.
Pedersen K, Canals F, Prat A, Tabernero J, Arribas J. | 04/26/2014 |
| The non-stop decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski complex. | The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells.
Saito S, Hosoda N, Hoshino S., Free PMC Article | 08/31/2013 |
| Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. | Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.
Pisareva VP, Skabkin MA, Hellen CU, Pestova TV, Pisarev AV., Free PMC Article | 07/9/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. | Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.
Burnicka-Turek O, Kata A, Buyandelger B, Ebermann L, Kramann N, Burfeind P, Hoyer-Fender S, Engel W, Adham IM., Free PMC Article | 07/12/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
Davis OS, Butcher LM, Docherty SJ, Meaburn EL, Curtis CJ, Simpson MA, Schalkwyk LC, Plomin R., Free PMC Article | 04/7/2010 |
| thrombopoietin-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2.
Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ., Free PMC Article | 01/21/2010 |