| Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism. | Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism.
Jersin RÅ, Sri Priyanka Tallapragada D, Skartveit L, Bjune MS, Muniandy M, Lee-Ødegård S, Heinonen S, Alvarez M, Birkeland KI, André Drevon C, Pajukanta P, McCann A, Pietiläinen KH, Claussnitzer M, Mellgren G, Dankel SN., Free PMC Article | 08/28/2023 |
| Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice. | Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Nakahara K, Okuda H, Isonishi A, Kawabe Y, Tanaka T, Tatsumi K, Wanaka A. | 01/7/2023 |
| Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance. | Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance.
Jersin RÅ, Tallapragada DSP, Madsen A, Skartveit L, Fjære E, McCann A, Lawrence-Archer L, Willems A, Bjune JI, Bjune MS, Våge V, Nielsen HJ, Thorsen HL, Nedrebø BG, Busch C, Steen VM, Blüher M, Jacobson P, Svensson PA, Fernø J, Rydén M, Arner P, Nygård O, Claussnitzer M, Ellingsen S, Madsen L, Sagen JV, Mellgren G, Dankel SN. | 09/25/2021 |
| Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population. | Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.
Suwandhi L, Altun I, Karlina R, Miok V, Wiedemann T, Fischer D, Walzthoeni T, Lindner C, Böttcher A, Heinzmann SS, Israel A, Khalil AEMM, Braun A, Pramme-Steinwachs I, Burtscher I, Schmitt-Kopplin P, Heinig M, Elsner M, Lickert H, Theis FJ, Ussar S., Free PMC Article | 03/27/2021 |
| These results suggest a role of Asc-1 in modulating presynaptic glycine levels that can impact on the respiratory network. | A neuronal role of the Alanine-Serine-Cysteine-1 transporter (SLC7A10, Asc-1) for glycine inhibitory transmission and respiratory pattern.
Mesuret G, Khabbazzadeh S, Bischoff AM, Safory H, Wolosker H, Hülsmann S., Free PMC Article | 10/12/2019 |
| this study shows that the astrocytic transporter SLC7A10 mediates glycinergic inhibition of spinal cord motor neurons | The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.
Ehmsen JT, Liu Y, Wang Y, Paladugu N, Johnson AE, Rothstein JD, du Lac S, Mattson MP, Höke A., Free PMC Article | 05/26/2018 |
| Asc-1 has a novel role in regulating NMDA receptor-dependent synaptic activity by mediating concurrent non-vesicular release of D-serine and glycine. | Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity.
Rosenberg D, Artoul S, Segal AC, Kolodney G, Radzishevsky I, Dikopoltsev E, Foltyn VN, Inoue R, Mori H, Billard JM, Wolosker H., Free PMC Article | 05/22/2017 |
| The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission | The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.
Safory H, Neame S, Shulman Y, Zubedat S, Radzishevsky I, Rosenberg D, Sason H, Engelender S, Avital A, Hülsmann S, Schiller J, Wolosker H., Free PMC Article | 02/6/2016 |
| The amino acid transporter ASC-1 is a white adipocyte-specific cell surface protein. | ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR., Free PMC Article | 10/17/2015 |
| The results presented reveal that Asc-1 is the only high affinity D-serine transporter in the mouse CNS and is the predominant mechanism for D-serine reuptake. | Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS.
Rutter AR, Fradley RL, Garrett EM, Chapman KL, Lawrence JM, Rosahl TW, Patel S. | 01/21/2010 |
| data support ASCT2 function in both neuron and astrocyte cultures and identify a discrepancy between observed asc-1 immunoreactivity and lack of functional asc-1 activity in neuron cultures, elucidating processes that govern D-serine regulation | Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures.
Shao Z, Kamboj A, Anderson CM. | 01/21/2010 |
| Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. | Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice.
Xie X, Dumas T, Tang L, Brennan T, Reeder T, Thomas W, Klein RD, Flores J, O'Hara BF, Heller HC, Franken P. | 01/21/2010 |