| Analysis of the MLH1, MLH2, MLH6, PMS2 genes and their correlations with clinical data in rectal mucinous adenocarcinoma. | Analysis of the MLH1, MLH2, MLH6, PMS2 genes and their correlations with clinical data in rectal mucinous adenocarcinoma.
Graur F, Puia A, Mois E, Pop P, Berar M, Elisei R, Zaharie F, Nechita V, Rusu I, Buiga R, Puia C, Al Hajjar N. | 05/7/2022 |
| Investigation of discordant sibling pairs from hereditary breast cancer families and analysis of a rare PMS1 variant. | Investigation of discordant sibling pairs from hereditary breast cancer families and analysis of a rare PMS1 variant.
Landry KK, Seward DJ, Dragon JA, Slavik M, Xu K, McKinnon WC, Colello L, Sweasy J, Wallace SS, Cuke M, Wood ME. | 02/19/2022 |
| Study suggests that rs1233255 SNP in PMS1 is associated with acute adverse events (AEs), and three SNPs, including rs4920657, rs5743030 and rs5743100 in PMS1, are associated with survival of rectal cancer patients receiving postoperative chemoradiotherapy (CRT). Therefore, these polymorphisms may be potential independent biomarkers for predicting AEs and prognosis in rectal cancer patients receiving postoperative CRT. | Associations of Genetic Variations in Mismatch Repair Genes MSH3 and PMS1 with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy.
Yang J, Huang Y, Feng Y, Li H, Feng T, Chen J, Yin L, Wang W, Wang S, Liu Y, Song Y, Li Y, Jin J, Tan W, Lin D., Free PMC Article | 12/21/2019 |
| Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. | Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population.
Liao M, Shi J, Huang L, Gao Y, Tan A, Wu C, Lu Z, Yang X, Zhang S, Hu Y, Qin X, Li J, Chen G, Xu J, Mo Z, Zhang H., Free PMC Article | 11/7/2015 |
| These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway. | Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.
Smith CE, Mendillo ML, Bowen N, Hombauer H, Campbell CS, Desai A, Putnam CD, Kolodner RD., Free PMC Article | 02/21/2015 |
| PMS1 is most likely deregulated by post-transcriptional modification in oral squamous cell carcinoma. | The mismatch repair gene hPMS1 (human postmeiotic segregation1) is down regulated in oral squamous cell carcinoma.
Wang Y, Zhou X, Song Y, Ji X, Zhang A, Zhang G, Gao Z. | 07/20/2013 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study of hypertension and blood pressure in African Americans.
Adeyemo A, Gerry N, Chen G, Herbert A, Doumatey A, Huang H, Zhou J, Lashley K, Chen Y, Christman M, Rotimi C., Free PMC Article | 12/2/2009 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of blood pressure and hypertension.
Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM., Free PMC Article | 05/17/2009 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S. | 03/25/2009 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group., Free PMC Article | 01/11/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesPolymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A. | 11/26/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (2) articlesComprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J. Common variants in mismatch repair genes and risk of colorectal cancer.
Koessler T, Oestergaard MZ, Song H, Tyrer J, Perkins B, Dunning AM, Easton DF, Pharoah PD. | 04/16/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (8) articlesRecapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.
Hong KW, Jin HS, Lim JE, Kim S, Go MJ, Oh B. Genetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer.
Koessler T, Azzato EM, Perkins B, Macinnis RJ, Greenberg D, Easton DF, Pharoah PD. Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients.
Mann A, Hogdall E, Ramus SJ, DiCioccio RA, Hogdall C, Quaye L, McGuire V, Whittemore AS, Shah M, Greenberg D, Easton DF, Ponder BA, Kjaer SK, Gayther SA, Thompson DJ, Pharoah PD, Song H. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.
Michiels S, Danoy P, Dessen P, Bera A, Boulet T, Bouchardy C, Lathrop M, Sarasin A, Benhamou S. Common variants in mismatch repair genes and risk of invasive ovarian cancer.
Song H, Ramus SJ, Quaye L, DiCioccio RA, Tyrer J, Lomas E, Shadforth D, Hogdall E, Hogdall C, McGuire V, Whittemore AS, Easton DF, Ponder BA, Kjaer SK, Pharoah PD, Gayther SA. | 03/13/2008 |
| Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization. | ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage.
Luo Y, Lin FT, Lin WC., Free PMC Article | 01/21/2010 |
| The expression of hMLH1 and hPMS1 was significantly low in some large B-cell lymphomas and in mantle cell lymphomas of the blastoid type and may be related to the natural history of these neoplasms. | Mismatch repair gene expression in malignant lymphoproliferative disorders of B-cell origin.
Kotoula V, Hytiroglou P, Kaloutsi V, Barbanis S, Kouidou S, Papadimitriou CS. | 01/21/2010 |
| hPMS1 may be useful as CD4+ helper T cell antigens for immunotherapy of pancreatic cancer patients. | Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis.
Okada T, Noji S, Goto Y, Iwata T, Fujita T, Okada T, Matsuzaki Y, Kuwana M, Hirakata M, Horii A, Matsuno S, Sunamura M, Kawakami Y. | 01/21/2010 |
| hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA | hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.
Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S., Free PMC Article | 01/21/2010 |
| In pstreplicative mismatch repair, this protein interacts wiwth MutL protein. | Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J. | 01/21/2010 |