| PLXNA1 confers enzalutamide resistance in prostate cancer via AKT signaling pathway. | PLXNA1 confers enzalutamide resistance in prostate cancer via AKT signaling pathway.
Hu J, Zhang J, Han B, Qu Y, Zhang Q, Yu Z, Zhang L, Han J, Liu H, Gao L, Feng T, Dou B, Chen W, Sun F., Free PMC Article | 10/15/2024 |
| PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner. | PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
Ye F, Xia T, Zhao M, Zhao W, Min P, Wang Y, Wang Q, Zhang Y, Du J. | 04/16/2024 |
| Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway. | Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.
Lu Y, Cheng D, Pang J, Peng Y, Jin S, Zhang X, Li Y, Zuo Y., Free PMC Article | 03/6/2024 |
| [PLXNA1 is highly expressed in hepatocellular carcinoma and affects patients' survival and immune microenvironment]. | [PLXNA1 is highly expressed in hepatocellular carcinoma and affects patients' survival and immune microenvironment].
Su L, Liang W, Lü Z, Han X., Free PMC Article | 12/18/2023 |
| Rare variant screening and burden analysis of PLXNA1 in Parkinson's disease. | Rare variant screening and burden analysis of PLXNA1 in Parkinson's disease.
Li C, Lin J, Jiang Q, Shang H. | 11/5/2022 |
| Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism. | Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism.
Men M, Chen DN, Li JD, Wang X, Zeng W, Jiang F, Zheng R, Dai W., Free PMC Article | 04/9/2022 |
| Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies. | Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies.
Dworschak GC, Punetha J, Kalanithy JC, Mingardo E, Erdem HB, Akdemir ZC, Karaca E, Mitani T, Marafi D, Fatih JM, Jhangiani SN, Hunter JV, Dakal TC, Dhabhai B, Dabbagh O, Alsaif HS, Alkuraya FS, Maroofian R, Houlden H, Efthymiou S, Dominik N, Salpietro V, Sultan T, Haider S, Bibi F, Thiele H, Hoefele J, Riedhammer KM, Wagner M, Guella I, Demos M, Keren B, Buratti J, Charles P, Nava C, Héron D, Heide S, Valkanas E, Waddell LB, Jones KJ, Oates EC, Cooper ST, MacArthur D, Syrbe S, Ziegler A, Platzer K, Okur V, Chung WK, O'Shea SA, Alcalay R, Fahn S, Mark PR, Guerrini R, Vetro A, Hudson B, Schnur RE, Hoganson GE, Burton JE, McEntagart M, Lindenberg T, Yilmaz Ö, Odermatt B, Pehlivan D, Posey JE, Lupski JR, Reutter H., Free PMC Article | 10/23/2021 |
| Our findings indicate that PLXNA1 variants cause not only anosmic but also normosmic IHH with a relatively high prevalence (3.9%). Heterozygous missense PLXNA1 variants appear to be involved together with other IHH gene variants in bringing about the IHH disease phenotype. | Prevalence and associated phenotypes of PLXNA1 variants in normosmic and anosmic idiopathic hypogonadotropic hypogonadism.
Kotan LD, Isik E, Turan I, Mengen E, Akkus G, Tastan M, Gurbuz F, Yuksel B, Topaloglu AK. | 04/4/2020 |
| Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction. | Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.
St Clair RM, Emerson SE, D'Elia KP, Weir ME, Schmoker AM, Ebert AM, Ballif BA., Free PMC Article | 11/3/2018 |
| PLEXA1 has a developmental and tumor-associated pro-angiogenic role in brain neoplasms | Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide.
Jacob L, Sawma P, Garnier N, Meyer LA, Fritz J, Hussenet T, Spenlé C, Goetz J, Vermot J, Fernandez A, Baumlin N, Aci-Sèche S, Orend G, Roussel G, Crémel G, Genest M, Hubert P, Bagnard D., Free PMC Article | 02/24/2018 |
| We thus screened 250 patients for the presence of mutations in PLXNA1, and identified different nonsynonymous mutations (p.V349L, p.V437L, p.R528W, p.H684Y, p.G720E, p.R740H, p.R813H, p.R840Q, p.A854T, p.R897H, p.L1464V, p.K1618T, p.C1744F), all at heterozygous state, in 15 patients. | Defective signaling through plexin-A1 compromises the development of the peripheral olfactory system and neuroendocrine reproductive axis in mice.
Marcos S, Monnier C, Rovira X, Fouveaut C, Pitteloud N, Ango F, Dodé C, Hardelin JP. | 10/21/2017 |
| Semaphorin-3a, neuropilin-1 and plexin-A1 are axonal guidance molecules that have been recently implicated in regulating bone metabolism. | Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.
Saad S, Dharmapatni AASSK, Crotti TN, Cantley MD, Algate K, Findlay DM, Atkins GJ, Haynes DR. | 09/24/2016 |
| a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established pancreatic cell line, is reported. | Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion.
Sorber R, Teper Y, Abisoye-Ogunniyan A, Waterfall JJ, Davis S, Killian JK, Pineda M, Ray S, McCord MR, Pflicke H, Burkett SS, Meltzer PS, Rudloff U., Free PMC Article | 07/30/2016 |
| Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques. | PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.
Belyk M, Kraft SJ, Brown S, Pediatric Imaging, Neurocognition and Genetics Study., Free PMC Article | 04/2/2016 |
| neuropilin 1 and plexin A1 transmembrane domains interaction | Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations.
Aci-Sèche S, Sawma P, Hubert P, Sturgis JN, Bagnard D, Jacob L, Genest M, Garnier N., Free PMC Article | 02/28/2015 |
| Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa. | [Expression of Plexin A1 in gastric carcinoma and its relationship with tumor angiogenesis and proliferation].
Zhao XY, Chen L, Xu Q, Li YH. | 03/8/2010 |
| Data show that the expression of Sema3A receptors (neuropilin-1 (NRP-1), NRP-2, plexin A1, plexin A2, and plexin A3) significantly increased during M-CSF-mediated differentiation of monocytes into macrophages. | Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.
Ji JD, Park-Min KH, Ivashkiv LB., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. | 04/1/2009 |
| In malignant pleural mesothelioma cells, plexin-A1 and VEGF-receptor 2 (VEGF-R2) are associated in a complex which are involved in survival pathways. | The plexin-A1 receptor activates vascular endothelial growth factor-receptor 2 and nuclear factor-kappaB to mediate survival and anchorage-independent growth of malignant mesothelioma cells.
Catalano A, Lazzarini R, Di Nuzzo S, Orciari S, Procopio A. | 01/21/2010 |
| PlexinA1 may play an important role in the occurrence and development of gastric carcinoma, and be related to tumor angiogenesis and proliferation. | PlexinA1 expression in gastric carcinoma and its relationship with tumor angiogenesis and proliferation.
Zhao XY, Chen L, Li YH, Xu Q., Free PMC Article | 01/21/2010 |
| Breast carcinoma cells support an autocrine pathway involving SEMA3A, plexin-A1, and NP1 that impedes their ability to chemotax. | Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.
Bachelder RE, Lipscomb EA, Lin X, Wendt MA, Chadborn NH, Eickholt BJ, Mercurio AM. | 01/21/2010 |