| PI3Kgamma maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. | PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Gu H, Chen C, Hou ZS, He XD, Xie S, Ni J, Qian C, Cheng X, Jiang T, Yang C, Roberts TM, Zheng J, Varner JA, Armstrong SA, Zhao JJ., | 06/26/2024 |
| Hypoxia Sensing of beta-Adrenergic Receptor Is Regulated by Endosomal PI3Kgamma. | Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.
Sun Y, Stenson K, Mohan ML, Gupta MK, Wanner N, Asosingh K, Erzurum S, Naga Prasad SV., Free PMC Article | 03/22/2023 |
| High expression of the phosphoinositide 3-kinase p11gamma isoform can predict poor prognosis of non-small cell lung cancer. | High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer.
Jung I, Lee HW, Roh MS, Lee JS, Kim K, Kim K, Kim TG, Nam HY. | 01/11/2023 |
| PI3Kgamma is a novel regulator of TNFalpha signaling in the human colon cell line HT29/B6. | PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6.
Klaus FL, Kirsch C, Müller JP, Huber O, Reiche J. | 10/1/2022 |
| Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kgamma activation in patients with chronic Chagas cardiomyopathy. | Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.
Silva MC, Fuzo CA, Marques Paiva I, Lopes Bibó N, Tavares de Oliveira M, da Silva Soares HA, Chevillard C, Kalil J, Cunha-Neto E, Cunha TM, Silva JS. | 09/17/2022 |
| A PI3Kgamma mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases. | A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Ghigo A, Murabito A, Sala V, Pisano AR, Bertolini S, Gianotti A, Caci E, Montresor A, Premchandar A, Pirozzi F, Ren K, Della Sala A, Mergiotti M, Richter W, de Poel E, Matthey M, Caldrer S, Cardone RA, Civiletti F, Costamagna A, Quinney NL, Butnarasu C, Visentin S, Ruggiero MR, Baroni S, Crich SG, Ramel D, Laffargue M, Tocchetti CG, Levi R, Conti M, Lu XY, Melotti P, Sorio C, De Rose V, Facchinetti F, Fanelli V, Wenzel D, Fleischmann BK, Mall MA, Beekman J, Laudanna C, Gentzsch M, Lukacs GL, Pedemonte N, Hirsch E., Free PMC Article | 04/9/2022 |
| Disease-related mutations in PI3Kgamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. | Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.
Rathinaswamy MK, Gaieb Z, Fleming KD, Borsari C, Harris NJ, Moeller BE, Wymann MP, Amaro RE, Burke JE., Free PMC Article | 03/19/2022 |
| Polymorphism in the catalytic subunit of the PI3Kgamma gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy. | Polymorphism in the catalytic subunit of the PI3Kγ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.
Silva MC, da Silva Medina T, Fuzo CA, Dias FC, Freitas-Castro F, Fukutani KF, Donadi EA, Cunha-Neto E, Cunha TM, Silva JS. | 03/19/2022 |
| MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma. | MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma.
Zhuang X, Gao F, Shi L, Liu W, Wang W, He X, Gao Y., Free PMC Article | 11/13/2021 |
| G protein betagamma translocation to the Golgi apparatus activates MAPK via p110gamma-p101 heterodimers. | G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers.
Khater M, Wei Z, Xu X, Huang W, Lokeshwar BL, Lambert NA, Wu G., Free PMC Article | 08/28/2021 |
| Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kalpha and PI3Kgamma. | Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ.
Martinez NG, Thieker DF, Carey LM, Rasquinha JA, Kistler SK, Kuhlman BA, Campbell SL., Free PMC Article | 06/26/2021 |
| Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kgamma isoform. | Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform.
Pei Y, Hwang N, Lang F, Zhou L, Wong JH, Singh RK, Jha HC, El-Deiry WS, Du Y, Robertson ES., Free PMC Article | 06/19/2021 |
| LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kgamma promoter. | LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter.
Ni H, Chai P, Yu J, Xing Y, Wang S, Fan J, Ge S, Wang Y, Jia R, Fan X., Free PMC Article | 03/27/2021 |
| Translocation of TRPV4-PI3Kgamma complexes to the plasma membrane drives myofibroblast transdifferentiation. | Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation.
Grove LM, Mohan ML, Abraham S, Scheraga RG, Southern BD, Crish JF, Naga Prasad SV, Olman MA., Free PMC Article | 08/22/2020 |
| Results emphasize the physiological importance of phosphatidylinositol 3-kinase-gamma (PI3Kgamma) in restraining inflammation and promoting appropriate adaptive immune responses in both humans and mice. | Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.
Takeda AJ, Maher TJ, Zhang Y, Lanahan SM, Bucklin ML, Compton SR, Tyler PM, Comrie WA, Matsuda M, Olivier KN, Pittaluga S, McElwee JJ, Long Priel DA, Kuhns DB, Williams RL, Mustillo PJ, Wymann MP, Koneti Rao V, Lucas CL., Free PMC Article | 01/18/2020 |
| The pharmacology regarding the potential application of umbelliferone, which contributes to cell death by decreasing p110gamma (PI3Kgamma) protein expression. | The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ.
Wang X, Huang S, Xin X, Ren Y, Weng G, Wang P. | 12/14/2019 |
| The results demonstrated that the MIR31HG-miR-31-ITIH5-PIK3CG pathway plays a role in the pathogenesis of Hirschsprung disease. | Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung's disease.
Cai P, Li H, Huo W, Zhu H, Xu C, Zang R, Lv W, Xia Y, Tang W. | 10/12/2019 |
| Circulating exosomal miR-301a-3p levels positively associated with depth of invasion, lymph node metastasis, late TNM stage, and poor prognosis of pancreatic cancer. Hypoxic exosomal miR-301a-3p induced the M2 polarization of macrophages via activation of the PTEN/PI3Kgamma signaling pathway. | Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis.
Wang X, Luo G, Zhang K, Cao J, Huang C, Jiang T, Liu B, Su L, Qiu Z. | 09/28/2019 |
| SNPs rs17847825 and rs2230460 significantly associated with protection from severe disease using the recessive model in patients infected with influenza A(H1N1)pdm09. | Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients.
Garcia CC, Tavares LP, Dias ACF, Kehdy F, Alvarado-Arnez LE, Queiroz-Junior CM, Galvão I, Lima BH, Matos AR, Gonçalves APF, Soriani FM, Moraes MO, Marques JT, Siqueira MM, Machado AMV, Sousa LP, Russo RC, Teixeira MM., Free PMC Article | 07/6/2019 |
| a novel role for GRK2 as a target of TCR signaling that is responsible for TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that signals via PI3Kgamma/PREX1 to mediate cytokine production. | GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion.
Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE., Free PMC Article | 03/2/2019 |
| High PIK3CG expression correlates with low parasitism in human chagasic hearts. These data identify a previously unrecognized role of the canonical PI3Kgamma signaling pathway in the control of T. cruzi infection. | Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM., Free PMC Article | 12/22/2018 |
| Results provide insight into the interrelationship between T-ALL oncogenic networks and the therapeutic efficacy of dual PI3Kgamma/delta inhibition in the context of NOTCH1 and cMYC signaling. | PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.
Efimenko E, Davé UP, Lebedeva IV, Shen Y, Sanchez-Quintero MJ, Diolaiti D, Kung A, Lannutti BJ, Chen J, Realubit R, Niatsetskaya Z, Ten V, Karan C, Chen X, Califano A, Diacovo TG., Free PMC Article | 07/21/2018 |
| PIK3CG gene rs12667819 was shown to be associated with attention-deficit/hyperactivity disorder (ADHD) risk in dominant model, ADHD-I type, and symptom scores. Gene-environmental interactions analysis revealed potential interactions of rs12667819 collaborating with blood lead and feeding style to modify ADHD risk. Expression quantitative trait loci analysis suggested that rs12667819 may mediate PIK3CG gene expression. | Association of PIK3CG gene polymorphisms with attention-deficit/hyperactivity disorder: A case-control study.
Gu X, Yuan FF, Huang X, Hou Y, Wang M, Lin J, Wu J. | 06/30/2018 |
| Predicted activities were further evaluated through in-vitro testing of gallic acid and serpentine targeting PI3Kgamma. | In-silico & In-vitro Identification of Structure-Activity Relationship Pattern of Serpentine & Gallic Acid Targeting PI3Kγ as Potential Anticancer Target.
Sharma P, Shukla A, Kalani K, Dubey V, Luqman S, Srivastava SK, Khan F. | 06/2/2018 |
| PI3Kdelta and PI3Kgamma inhibition with IPI-145 has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK | Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.
Pillinger G, Loughran NV, Piddock RE, Shafat MS, Zaitseva L, Abdul-Aziz A, Lawes MJ, Bowles KM, Rushworth SA., Free PMC Article | 01/13/2018 |