| CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1. | CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1.
Hua J, Gao Z, Zhong S, Wei B, Zhu J, Ying R. | 11/27/2021 |
| Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. | Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure.
Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S., Free PMC Article | 08/14/2021 |
| Study uncovered elevated presynaptic mitochondrial protein levels of mitoNEET in P42 compared to P7 mice. Overexpression of mitoNEET resulted in increased ATP production, elevated mitochondrial membrane potential, and a fragmented mitochondrial network with decreased mitochondrial biomass in cells of neuronal origin. | Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development.
Stauch KL, Villeneuve LM, Totusek S, Lamberty B, Ciborowski P, Fox HS., Free PMC Article | 02/15/2020 |
| MitoNEET in perivascular adipose tissue prevents PVAT inflammation and is negatively associated with arterial stiffness in aging mice. | MitoNEET in Perivascular Adipose Tissue Prevents Arterial Stiffness in Aging Mice.
Chang L, Zhao X, Garcia-Barrio M, Zhang J, Eugene Chen Y. | 05/11/2019 |
| mNEET plays a specific role in the formation of intermitochondrial junctions and thus participates in the adaptation of cells to physiological changes and to the control of mitochondrial homeostasis. | MitoNEET-dependent formation of intermitochondrial junctions.
Vernay A, Marchetti A, Sabra A, Jauslin TN, Rosselin M, Scherer PE, Demaurex N, Orci L, Cosson P., Free PMC Article | 05/26/2018 |
| Together, these data suggest that mitoNEET KO mice exhibit many of the characteristics of early neurodegeneration in PD and may provide a novel drug discovery platform to evaluate compounds for enhancing mitochondrial function in neurodegenerative disorders. | MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Geldenhuys WJ, Benkovic SA, Lin L, Yonutas HM, Crish SD, Sullivan PG, Darvesh AS, Brown CM, Richardson JR., Free PMC Article | 02/3/2018 |
| mitoNEET protects intact cardiac cells from oxidative stress induced apoptosis during hypoxia and reoxygenation. | MitoNEET Protects HL-1 Cardiomyocytes from Oxidative Stress Mediated Apoptosis in an In Vitro Model of Hypoxia and Reoxygenation.
Habener A, Chowdhury A, Echtermeyer F, Lichtinghagen R, Theilmeier G, Herzog C., Free PMC Article | 07/22/2017 |
| The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice. | MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis.
Hu X, Jogasuria A, Wang J, Kim C, Han Y, Shen H, Wu J, You M., Free PMC Article | 05/27/2017 |
| the mitoNEET-enriched fat pads feature a more vascularized, anti-inflammatory and less fibrotic environment. | MitoNEET-mediated effects on browning of white adipose tissue.
Kusminski CM, Park J, Scherer PE., Free PMC Article | 10/31/2015 |
| The MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. | Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.
Roberts ME, Crail JP, Laffoon MM, Fernandez WG, Menze MA, Konkle ME. | 03/8/2014 |
| study found that overexpression of mitoNEET enhances lipid uptake and storage, leading to an expansion of the mass of adipose tissue | MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.
Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE., Free PMC Article | 01/12/2013 |
| mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates | MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.
Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE., Free PMC Article | 01/21/2010 |
| mitoNEET is located in mitochondrial fraction of adipocytes. | Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe.
Colca JR, McDonald WG, Waldon DJ, Leone JW, Lull JM, Bannow CA, Lund ET, Mathews WR. | 01/21/2010 |