| CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway. | CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
Dou Z, Lu F, Hu J, Li B, Li X., Free PMC Article | 07/16/2024 |
| Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. | Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
Cho KW, Andrade M, Bae S, Kim S, Eyun Kim J, Jang EY, Lee S, Husain A, Sutliff RL, Calvert JW, Park C, Yoon YS., Free PMC Article | 06/15/2023 |
| CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability. | CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
Wu Y, Li B, Yu D, Zhou Z, Shen M, Jiang F., Free PMC Article | 06/1/2023 |
| Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway. | Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
Zhang HT, Wang XZ, Zhang QM, Zhao H. | 04/23/2022 |
| A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells. | A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
Jaensch ES, Zhu J, Cochrane JC, Marr SK, Oei TA, Damle M, McCaslin EZ, Kingston RE., Free PMC Article | 01/8/2022 |
| Mass spectrometry analysis revealed several non-histone protein interactions between CBX7 and the H3K9 methyltransferases SETDB1, EHMT1, and EHMT2. These CBX7-binding proteins possess a trimethylated lysine peptide motif highly similar to the canonical CBX7 target H3K27me3. | CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.
Jung J, Buisman SC, Weersing E, Dethmers-Ausema A, Zwart E, Schepers H, Dekker MR, Lazare SS, Hammerl F, Skokova Y, Kooistra SM, Klauke K, Poot RA, Bystrykh LV, de Haan G. | 04/25/2020 |
| Knockdown of CBX7 in either embryonic cortical neurons or adult dorsal root ganglion (DRG) neurons enhances their axon growth ability. Two important transcription factors GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration. | Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration.
Duan RS, Tang GB, Du HZ, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM., Free PMC Article | 09/14/2019 |
| CBX7 deficiency has a positive effect on tooth extraction socket healing. | Effect of CBX7 deficiency on the socket healing after tooth extractions.
Jiang F, Yang X, Meng X, Zhou Z, Chen N. | 08/31/2019 |
| Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin. | Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
Zhen CY, Tatavosian R, Huynh TN, Duc HN, Das R, Kokotovic M, Grimm JB, Lavis LD, Lee J, Mejia FJ, Li Y, Yao T, Ren X., Free PMC Article | 11/4/2017 |
| these results of this study suggest that CBX7 deficiency plays a positive role in dentin and alveolar bone formation. | CBX7 deficiency plays a positive role in dentin and alveolar bone development.
Zhou Z, Yin Y, Jiang F, Niu Y, Wan S, Chen N, Shen M. | 02/18/2017 |
| CD4(+) T cells express Cbx7; the latter prevents FasL expression and the activation-induced CD4(+) T cell apoptosis. | Polycomb chromobox (Cbx) 7 modulates activation-induced CD4+ T cell apoptosis.
Li J, Li Y, Cao Y, Yuan M, Gao Z, Guo X, Zhu F, Wang Y, Xu J. | 02/14/2015 |
| Threonine 118 is a novel phosphorylation site of mouse Cbx7. Cbx7T118 phosphorylation moderately enhances repression of its target gene p16. | Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7.
Wu HA, Balsbaugh JL, Chandler H, Georgilis A, Zullow H, Shabanowitz J, Hunt DF, Gil J, Peters G, Bernstein E., Free PMC Article | 03/8/2014 |
| Although the genomic localization of the Cbx7- and RYBP-containing PRC1 complexes overlaps in certain genes, it can also be mutually exclusive. | RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells.
Morey L, Aloia L, Cozzuto L, Benitah SA, Di Croce L. | 07/20/2013 |
| MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. | MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.
O'Loghlen A, Muñoz-Cabello AM, Gaspar-Maia A, Wu HA, Banito A, Kunowska N, Racek T, Pemberton HN, Beolchi P, Lavial F, Masui O, Vermeulen M, Carroll T, Graumann J, Heard E, Dillon N, Azuara V, Snijders AP, Peters G, Bernstein E, Gil J., Free PMC Article | 05/5/2012 |
| These data suggest that CBX7 is a tumor suppressor and that its loss plays a key role in the pathogenesis of cancer. | CBX7 is a tumor suppressor in mice and humans.
Forzati F, Federico A, Pallante P, Abbate A, Esposito F, Malapelle U, Sepe R, Palma G, Troncone G, Scarfò M, Arra C, Fedele M, Fusco A., Free PMC Article | 04/21/2012 |
| controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways | Polycomb CBX7 has a unifying role in cellular lifespan.
Gil J, Bernard D, Martínez D, Beach D. | 01/21/2010 |
| CBX7 is a chromobox protein causally linked to cancer development | Role of the chromobox protein CBX7 in lymphomagenesis.
Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martínez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW., Free PMC Article | 01/21/2010 |