| Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer. | Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer.
Liu Y, Shi Q, Liu Y, Li X, Wang Z, Huang S, Chen Z, He X. | 09/23/2024 |
| MiR-3195 inhibits non-small cell lung cancer malignant behaviors along with cisplatin resistance through targeting PFKFB4. | MiR-3195 inhibits non-small cell lung cancer malignant behaviors along with cisplatin resistance through targeting PFKFB4.
Chen R, Gao X, Shen Y. | 08/6/2024 |
| Expression and prognostic analysis of PFKFB4 in oral squamous cell carcinoma. | Expression and prognostic analysis of PFKFB4 in oral squamous cell carcinoma.
Chen S, Han J, Wang W, Wu Z, Wang J, Cheng B. | 08/6/2024 |
| Transforming growth factor beta1 upregulates 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-4 expression in A549 and MCF-10A cells. | Transforming growth factor β1 upregulates 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-4 expression in A549 and MCF-10A cells.
Altunok TH, Muchut RJ, Iglesias AA, Yalcin A. | 12/22/2023 |
| THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification. | THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification.
Yu T, Zhang Q, Yu SK, Nie FQ, Zhang ML, Wang Q, Lu KH., Free PMC Article | 08/2/2023 |
| PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner. | PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner.
Kam CS, Ho DW, Ming VS, Tian L, Sze KM, Zhang VX, Tsui YM, Husain A, Lee JM, Wong CC, Chan AC, Cheung TT, Chan LK, Ng IO., Free PMC Article | 05/22/2023 |
| PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation. | PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation.
Olaizola P, Banales JM., Free PMC Article | 05/22/2023 |
| Loss of PFKFB4 induces cell cycle arrest and glucose metabolism inhibition by inactivating MEK/ERK/c-Myc pathway in cervical cancer cells. | Loss of PFKFB4 induces cell cycle arrest and glucose metabolism inhibition by inactivating MEK/ERK/c-Myc pathway in cervical cancer cells.
Wu Y, Zhang L, Bao Y, Wan B, Shu D, Luo T, He Z. | 10/8/2022 |
| Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis. | Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis.
Lu C, Qiao P, Fu R, Wang Y, Lu J, Ling X, Liu L, Sun Y, Ren C, Yu Z., Free PMC Article | 10/1/2022 |
| PFKFB4 modulated by miR-195-5p can boost the malignant progression of cervical cancer cells. | PFKFB4 modulated by miR-195-5p can boost the malignant progression of cervical cancer cells.
Sun J, Jin R. | 08/27/2022 |
| PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma. | PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma.
Sittewelle M, Kappès V, Zhou C, Lécuyer D, Monsoro-Burq AH., Free PMC Article | 08/6/2022 |
| Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4(DDB2) E3 Ubiquitin Ligase-mediated p27 Degradation. | Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4(DDB2) E3 Ubiquitin Ligase-mediated p27 Degradation.
Chen H, Yang R, Xing L, Wang B, Liu D, Ou X, Deng Y, Jiang R, Chen J., Free PMC Article | 07/23/2022 |
| PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance. | PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance.
Feng C, Li Y, Li K, Lyu Y, Zhu W, Jiang H, Wen H., Free PMC Article | 02/5/2022 |
| PFKFB4 Overexpression Facilitates Proliferation by Promoting the G1/S Transition and Is Associated with a Poor Prognosis in Triple-Negative Breast Cancer. | PFKFB4 Overexpression Facilitates Proliferation by Promoting the G1/S Transition and Is Associated with a Poor Prognosis in Triple-Negative Breast Cancer.
Cai YC, Yang H, Shan HB, Su HF, Jiang WQ, Shi YX., Free PMC Article | 12/11/2021 |
| Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes. | Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes.
Cheung RA, Kraft AM, Petty HR. | 11/13/2021 |
| Expression of Alternative Splice Variants of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-4 in Normoxic and Hypoxic Melanoma Cells. | Expression of Alternative Splice Variants of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-4 in Normoxic and Hypoxic Melanoma Cells.
Trojan SE, Dudzik P, Totoń-Żurańska J, Laidler P, Kocemba-Pilarczyk KA., Free PMC Article | 09/18/2021 |
| PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2. | PFKFB4 promotes lung adenocarcinoma progression via phosphorylating and activating transcriptional coactivator SRC-2.
Meng J, Chen X, Han Z., Free PMC Article | 02/27/2021 |
| PFKFB4 is critical for the survival of acute monocytic leukemia cells. | PFKFB4 is critical for the survival of acute monocytic leukemia cells.
Wang G, Li S, Xue K, Dong S. | 11/28/2020 |
| This study aims to characterise the expression and phosphorylation of isozymes of the key glycolytic regulatory protein, 6-phosphofructokinase-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2), in urinary exosomes of subjects with pre-eclampsia . | Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia.
Ellis R, Katerelos M, Choy SW, Cook N, Lee M, Paizis K, Pell G, Walker S, Power DA, Mount PF., Free PMC Article | 04/25/2020 |
| CD44ICD interacts with CREB and binds to the promoter region of PFKFB4, thereby regulating PFKFB4 transcription and expression. | CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism.
Gao R, Li D, Xun J, Zhou W, Li J, Wang J, Liu C, Li X, Shen W, Qiao H, Stupack DG, Luo N., Free PMC Article | 10/26/2019 |
| Epithelial and endothelial tyrosine kinase (Etk) interacts with 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) to promote small-cell lung cancer (SCLC) chemoresistance through regulation of autophagy. | Etk Interaction with PFKFB4 Modulates Chemoresistance of Small-cell Lung Cancer by Regulating Autophagy.
Wang Q, Zeng F, Sun Y, Qiu Q, Zhang J, Huang W, Huang J, Huang X, Guo L. | 09/28/2019 |
| Currently available anti-melanoma therapeutic strategies may significantly benefit from agents targeting PFKFB4 activity. | Analysis of Malignant Melanoma Cell Lines Exposed to Hypoxia Reveals the Importance of PFKFB4 Overexpression for Disease Progression.
Trojan SE, Piwowar M, Ostrowska B, Laidler P, Kocemba-Pilarczyk KA. | 01/12/2019 |
| PFKFB4 enhances the invasiveness of breast cancer cells in vitro and in vivo by inducing HA production and PFKFB4-induced expression of HAS2 depends upon the activation of p38 signaling. | PFKFB4 Promotes Breast Cancer Metastasis via Induction of Hyaluronan Production in a p38-Dependent Manner.
Gao R, Liu Y, Li D, Xun J, Zhou W, Wang P, Liu C, Li X, Shen W, Su W, Qiao H, Stupack DG, Luo N. | 12/22/2018 |
| findings suggest that the Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours | Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.
Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW., Free PMC Article | 08/18/2018 |
| Data show that PFKFB4 is the target gene of PPARgamma which modulates the transcriptional activity of its promoter. | Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4.
Shu Y, Lu Y, Pang X, Zheng W, Huang Y, Li J, Ji J, Zhang C, Shen P., Free PMC Article | 02/17/2018 |