| Properdin produced by dendritic cells contributes to the activation of T cells. | Properdin produced by dendritic cells contributes to the activation of T cells.
van Essen MF, Schlagwein N, van Gijlswijk-Janssen DJ, Ruben JM, van Kooten C, COMBAT consortium. | 08/13/2022 |
| Structure and function of a family of tick-derived complement inhibitors targeting properdin. | Structure and function of a family of tick-derived complement inhibitors targeting properdin.
Braunger K, Ahn J, Jore MM, Johnson S, Tang TTL, Pedersen DV, Andersen GR, Lea SM., Free PMC Article | 02/19/2022 |
| The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa. | The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa.
Martinez APG, Abreu PAE, de Arruda Vasconcellos S, Ho PL, Ferreira VP, Saggu G, Barbosa AS, Isaac L., Free PMC Article | 06/19/2021 |
| Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model. | Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model.
Al-Rayahi IAM, Machado LR, Stover CM., Free PMC Article | 05/8/2021 |
| Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. | Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation.
Chen JY, Galwankar NS, Emch HN, Menon SS, Cortes C, Thurman JM, Merrill SA, Brodsky RA, Ferreira VP., Free PMC Article | 05/1/2021 |
| Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement. | Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.
Zhang J, Song L, Pedersen DV, Li A, Lambris JD, Andersen GR, Mollnes TE, Ma YJ, Garred P., Free PMC Article | 03/6/2021 |
| TES-mediated upregulation of the transcription factor DDIT3 is involved in CFP suppression of breast cancer cell growth | CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.
Block I, Müller C, Sdogati D, Pedersen H, List M, Jaskot AM, Syse SD, Lund Hansen P, Schmidt S, Christiansen H, Casella C, Bering Olsen S, Blomstrøm MM, Riedel A, Thomassen M, Kruse TA, Karlskov Hansen SW, Kioschis P, Mollenhauer J. | 01/4/2020 |
| Study identified 2 single nucleotide polymorphisms, 1 in the mannose-binding lectin 2 gene (p.Gly54Asp-MBL2) and 1 in the complement factor properdin gene (p.Asn428(p=)-CFP), that showed significant association with the absence and development of antibody-mediated cardiac allograft rejection, respectively. | Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection.
Marrón-Liñares GM, Núñez L, Crespo-Leiro MG, Barge-Caballero E, Pombo J, Paniagua-Martin MJ, Suarez-Fuentetaja N, Cid J, Grille-Cancela Z, Muñiz-Garcia J, Tan CD, Rodríguez ER, Vázquez-Rodríguez JM, Hermida-Prieto M. | 11/23/2019 |
| Compound heterozygous mutations in IL10RA combined with a complement factor properdin mutation in infantile-onset inflammatory bowel disease. | Compound heterozygous mutations in IL10RA combined with a complement factor properdin mutation in infantile-onset inflammatory bowel disease.
Jung ES, Petersen BS, Mayr G, Cheon JH, Kang Y, Lee SJ, Che X, Kim WH, Kim S, Schreiber S, Franke A, Koh H. | 03/9/2019 |
| In conclusion, we challenge the view of properdin as a pattern recognition molecule by providing evidence that it binds to different exogenous and endogenous molecular patterns in only a C3-dependent manner. | Properdin binding to complement activating surfaces depends on initial C3b deposition.
Harboe M, Johnson C, Nymo S, Ekholt K, Schjalm C, Lindstad JK, Pharo A, Hellerud BC, Nilsson Ekdahl K, Mollnes TE, Nilsson PH., Free PMC Article | 04/14/2018 |
| data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation | Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood.
Blatt AZ, Saggu G, Kulkarni KV, Cortes C, Thurman JM, Ricklin D, Lambris JD, Valenzuela JG, Ferreira VP., Free PMC Article | 09/30/2017 |
| this study shows that RNA interference of properdin in dendritic cells decreased alloantigen-specific T-cell proliferation | Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-γ.
Dixon KO, O'Flynn J, Klar-Mohamad N, Daha MR, van Kooten C., Free PMC Article | 07/22/2017 |
| studies demonstrate an essential role of properdin oligomerization in vivo while our monomers enable detailed structural insight paving the way for novel modulators of complement. | Functional and structural insight into properdin control of complement alternative pathway amplification.
Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR., Free PMC Article | 04/29/2017 |
| P serum level expression could be a reliable clinical biomarker to identify patients with underlying surface alternative pathway C5 convertase dysregulation. | Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy.
Corvillo F, Bravo García-Morato M, Nozal P, Garrido S, Tortajada A, Rodríguez de Córdoba S, López-Trascasa M., Free PMC Article | 07/30/2016 |
| can directly interact with neutrophil myeloperoxidase resulting in activation of alternative pathway of complement | Myeloperoxidase directs properdin-mediated complement activation.
O'Flynn J, Dixon KO, Faber Krol MC, Daha MR, van Kooten C., Free PMC Article | 05/16/2015 |
| In the pathogenesis of renal tubular damage, P can directly bind to PTECs and may accelerate AP activation by surpassing fH regulation | Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage.
Nagamachi S, Ohsawa I, Suzuki H, Sato N, Inoshita H, Hisada A, Honda D, Shimamoto M, Shimizu Y, Horikoshi S, Tomino Y., Free PMC Article | 12/20/2014 |
| Our data show that physiological forms of human properdin bind directly to human platelets after activation by strong agonists in the absence of C3 | Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O).
Saggu G, Cortes C, Emch HN, Ramirez G, Worth RG, Ferreira VP., Free PMC Article | 08/31/2013 |
| Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. | Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
Zaferani A, Vivès RR, van der Pol P, Navis GJ, Daha MR, van Kooten C, Lortat-Jacob H, Seelen MA, van den Born J., Free PMC Article | 11/24/2012 |
| Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner. | The role of properdin in zymosan- and Escherichia coli-induced complement activation.
Harboe M, Garred P, Lindstad JK, Pharo A, Müller F, Stahl GL, Lambris JD, Mollnes TE., Free PMC Article | 11/3/2012 |
| Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation. | Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
Somani R, Richardson VR, Standeven KF, Grant PJ, Carter AM., Free PMC Article | 08/11/2012 |
| Immune human serum that contained bactericidal Abs directed against the 2C7 lipooligosaccharide epitope required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains. | Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
Gulati S, Agarwal S, Vasudhev S, Rice PA, Ram S., Free PMC Article | 06/9/2012 |
| report a large Finnish family with a novel mutation in the properdin gene. The mutation is located in exon 9 and changes guanine to adenine at nucleotide 1164 (c.1164G>A) that causes tryptophan to change to a premature stop codon (W388X). | A novel mutation W388X underlying properdin deficiency in a Finnish family.
Helminen M, Seitsonen S, Jarva H, Meri S, Järvelä IE., Free PMC Article | 05/5/2012 |
| tubular HS as a novel docking platform for alternative pathway activation via properdin, which might play a role in proteinuric renal damage. | Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease.
Zaferani A, Vivès RR, van der Pol P, Hakvoort JJ, Navis GJ, van Goor H, Daha MR, Lortat-Jacob H, Seelen MA, van den Born J., Free PMC Article | 04/16/2011 |
| levels of properdin are not associated with childhood wheezing and atopy | Properdin in childhood and its association with wheezing and atopy.
Staley KG, Kuehni CE, Strippoli MP, McNally T, Silverman M, Stover C. | 03/12/2011 |
| Human properdin can selectively recognize surfaces and enhance or promote alternative pathway of complement activation. | Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement.
Ferreira VP, Cortes C, Pangburn MK., Free PMC Article | 02/26/2011 |