| H2A.Z is involved in premature aging and DSB repair initiation in muscle fibers. | H2A.Z is involved in premature aging and DSB repair initiation in muscle fibers.
Belotti E, Lacoste N, Iftikhar A, Simonet T, Papin C, Osseni A, Streichenberger N, Mari PO, Girard E, Graies M, Giglia-Mari G, Dimitrov S, Hamiche A, Schaeffer L., Free PMC Article | 05/9/2024 |
| Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival. | Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.
Lowden C, Boulet A, Boehler NA, Seecharran S, Rios Garcia J, Lowe NJ, Liu J, Ong JLK, Wang W, Ma L, Cheng AH, Senatore A, Monks DA, Liu BH, Leary SC, Cheng HM. | 02/19/2022 |
| The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons. | The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons.
Stefanelli G, Makowski CE, Brimble MA, Hall M, Reda A, Creighton SD, Leonetti AM, McLean TAB, Zakaria JM, Baumbach J, Greer CB, Davidoff AM, Walters BJ, Murphy PJ, Zovkic IB., Free PMC Article | 02/12/2022 |
| Structural basis of chromatin regulation by histone variant H2A.Z. | Structural basis of chromatin regulation by histone variant H2A.Z.
Lewis TS, Sokolova V, Jung H, Ng H, Tan D., Free PMC Article | 12/25/2021 |
| A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation. | A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation.
Mylonas C, Lee C, Auld AL, Cisse II, Boyer LA. | 07/24/2021 |
| CpG Islands Shape the Epigenome Landscape. | CpG Islands Shape the Epigenome Landscape.
Papin C, Le Gras S, Ibrahim A, Salem H, Karimi MM, Stoll I, Ugrinova I, Schröder M, Fontaine-Pelletier E, Omran Z, Bronner C, Dimitrov S, Hamiche A. | 05/8/2021 |
| Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain. | Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain.
Ramzan F, Creighton SD, Hall M, Baumbach J, Wahdan M, Poulson SJ, Michailidis V, Stefanelli G, Narkaj K, Tao CS, Khan D, Steininger CFD Jr, Walters BJ, Monks DA, Martin LJ, Zovkic IB., Free PMC Article | 03/20/2021 |
| H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles. | H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
Belotti E, Lacoste N, Simonet T, Papin C, Padmanabhan K, Scionti I, Gangloff YG, Ramos L, Dalkara D, Hamiche A, Dimitrov S, Schaeffer L., Free PMC Article | 09/12/2020 |
| H2A.Z.1 is a key regulator of gliogenesis because it interacts with ASF1a to regulate H3K56ac and then directly affects the expression of FOLR1, which acts as a signal-transducing component of the JAK-STAT signaling pathway. | H2A.Z.1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor.
Su L, Xia W, Shen T, Liang Q, Wang W, Li H, Jiao J., Free PMC Article | 08/17/2019 |
| Loss of histone H2A.Z (H2A.z) expression impairs neurogenesis. | Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder.
Shen T, Ji F, Wang Y, Lei X, Zhang D, Jiao J., Free PMC Article | 07/27/2019 |
| Our data show that H2A.Z accumulates in aged mice, but it is widely removed from chromatin during learning irrespective of age, whereas H2A.Z incorporation is a rare event at either age | Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus.
Stefanelli G, Azam AB, Walters BJ, Brimble MA, Gettens CP, Bouchard-Cannon P, Cheng HM, Davidoff AM, Narkaj K, Day JJ, Kennedy AJ, Zovkic IB., Free PMC Article | 06/1/2019 |
| This study provides key insights into the mechanism of how histone variants H3.3 and H2A.Z function coordinately to finely tune the PRC2 enzymatic activity during gene silencing, through promoting or impairing chromosome compaction respectively. | Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells.
Wang Y, Long H, Yu J, Dong L, Wassef M, Zhuo B, Li X, Zhao J, Wang M, Liu C, Wen Z, Chang L, Chen P, Wang QF, Xu X, Margueron R, Li G., Free PMC Article | 05/4/2019 |
| Znhit1 promotes the interaction between H2A.Z and YL1 (H2A.Z chaperone) by controlling YL1 phosphorylation. These results demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell maintenance and intestinal homeostasis. | Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.
Zhao B, Chen Y, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G, Lin X., Free PMC Article | 04/13/2019 |
| The data also suggest that H2A.Z restricts transcription, which is moderated by ANP32e at the promoter and gene bodies of expressed genes. Thus, ANP32e, through inhibition of PP2A, is required for nucleosomal inclusion of H2A.Z and the regulation of gene expression | Transcriptional regulation mediated by H2A.Z via ANP32e-dependent inhibition of protein phosphatase 2A.
Shin H, He M, Yang Z, Jeon YH, Pfleger J, Sayed D, Abdellatif M., Free PMC Article | 07/14/2018 |
| In contrast to H2A-interacting proteins, the H2A.Z-interacting proteins are involved in transcriptional regulation. We found that the transcription factor Osr1 interacts with H2A.Z both in vitro and in vivo. It also mediates H2A.Z incorporation to a large number of target sites and regulates gene expression | Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq.
Zhang Y, Ku WL, Liu S, Cui K, Jin W, Tang Q, Lu W, Ni B, Zhao K., Free PMC Article | 05/26/2018 |
| This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs. | H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs.
Surface LE, Fields PA, Subramanian V, Behmer R, Udeshi N, Peach SE, Carr SA, Jaffe JD, Boyer LA., Free PMC Article | 11/5/2016 |
| Embryonic stem cell BAF is required for normal H2A.Z localization in these cells, suggesting BAF either stabilizes H2A.Z containing nucleosomes or promotes subnucleosome to nucleosome conversion by facilitating H2A.Z deposition. | Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome.
Hainer SJ, Fazzio TG., Free PMC Article | 07/16/2016 |
| Study mapped H2A.Z genome-wide in embryonic stem cells and neural progenitors; H2A.Z is deposited at promoters and enhancers, and correlates strongly with H3K4 methylation. H2A.Z is present at poised promoters with bivalent chromatin and at active promoters with H3K4 methylation, but is absent from stably repressed promoters that are enriched for H3K27 trimethylation. | H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions.
Ku M, Jaffe JD, Koche RP, Rheinbay E, Endoh M, Koseki H, Carr SA, Bernstein BE., Free PMC Article | 04/4/2015 |
| our work suggests that the divergent residues in the H2A.Z acidic patch comprise a unique domain that couples control of chromatin dynamics to the regulation of developmental gene expression patterns during lineage commitment. | H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation.
Subramanian V, Mazumder A, Surface LE, Butty VL, Fields PA, Alwan A, Torrey L, Thai KK, Levine SS, Bathe M, Boyer LA., Free PMC Article | 03/22/2014 |
| Data propose that H2A.Z mediates such contrasting activities by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive. | H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.
Hu G, Cui K, Northrup D, Liu C, Wang C, Tang Q, Ge K, Levens D, Crane-Robinson C, Zhao K., Free PMC Article | 08/31/2013 |
| The variant histone H2A.Z and the winged helix transcription factor Foxa2 both act to regulate nucleosome depletion and gene activation, thus promoting embryonic stem cell differentiation, whereas DNA methylation promotes nucleosome occupation and suppresses gene expression. | Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation.
Li Z, Gadue P, Chen K, Jiao Y, Tuteja G, Schug J, Li W, Kaestner KH., Free PMC Article | 03/2/2013 |
| incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation | The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.
Couture JP, Nolet G, Beaulieu E, Blouin R, Gévry N. | 02/2/2013 |
| In mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS becoming heterotypic (H2A.Z-H2A). | Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics.
Nekrasov M, Amrichova J, Parker BJ, Soboleva TA, Jack C, Williams R, Huttley GA, Tremethick DJ. | 01/26/2013 |
| It was shown that Ring1B interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed, Ring1B and CpG islands in chromatin, H2A.Z still blanketed polycomb target loci in the absence of Suz12, Eed, or Ring1B. | PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.
Illingworth RS, Botting CH, Grimes GR, Bickmore WA, Eskeland R., Free PMC Article | 08/25/2012 |
| Studies indicate that the unique chromatin landscape also includes a second histone variant, H2A.Z. | A unique H2A histone variant occupies the transcriptional start site of active genes.
Soboleva TA, Nekrasov M, Pahwa A, Williams R, Huttley GA, Tremethick DJ. | 03/10/2012 |