| PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function. | PDZK1 protects against mechanical overload-induced chondrocyte senescence and osteoarthritis by targeting mitochondrial function.
Shao Y, Zhang H, Guan H, Wu C, Qi W, Yang L, Yin J, Zhang H, Liu L, Lu Y, Zhao Y, Zhang S, Zeng C, Wang G, Bai X, Cai D., Free PMC Article | 08/16/2024 |
| Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1. | Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1.
Ren X, Deng D, Xiang S, Feng J., Free PMC Article | 05/28/2024 |
| CHD4 and SMYD1 repress common transcriptional programs in the developing heart. | CHD4 and SMYD1 repress common transcriptional programs in the developing heart.
Shi W, Wasson LK, Dorr KM, Robbe ZL, Wilczewski CM, Hepperla AJ, Davis IJ, Seidman CE, Seidman JG, Conlon FL., Free PMC Article | 05/23/2024 |
| PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma. | PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma.
Zhang Y, Wang F, Huang Y., Free PMC Article | 05/23/2024 |
| PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway. | PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway.
Ma Y, Fang Z, Zhang H, Qi Y, Mao Y, Zheng J., Free PMC Article | 04/30/2024 |
| Interaction of Human OATP1B1 with PDZK1 Is Required for Its Trafficking to the Hepatocyte Plasma Membrane. | Interaction of Human OATP1B1 with PDZK1 Is Required for Its Trafficking to the Hepatocyte Plasma Membrane.
Wang P, Murray JW, Wolkoff AW., Free PMC Article | 09/19/2023 |
| HBV Infection-Related PDZK1 Plays an Oncogenic Role by Regulating the PI3K-Akt Pathway and Fatty Acid Metabolism and Enhances Immunosuppression. | HBV Infection-Related PDZK1 Plays an Oncogenic Role by Regulating the PI3K-Akt Pathway and Fatty Acid Metabolism and Enhances Immunosuppression.
Chen X, Wang X, Zhu F, Qian C, Xu F, Huang X, Zhang W, Sun B., Free PMC Article | 09/10/2022 |
| PDZK1 induces resistance to apoptosis in esophageal adenocarcinoma cells. | PDZK1 induces resistance to apoptosis in esophageal adenocarcinoma cells.
Handa O, Goda K, Handa Y, Fukushima S, Osawa M, Murao T, Matsumoto H, Umegaki E, Fujita Y, Nishio K, Shiotani A. | 04/2/2022 |
| Interleukin-37 contributes to the pathogenesis of gout by affecting PDZ domain-containing 1 protein through the nuclear factor-kappa B pathway. | Interleukin-37 contributes to the pathogenesis of gout by affecting PDZ domain-containing 1 protein through the nuclear factor-kappa B pathway.
Wan W, Shi Y, Ji L, Li X, Xu X, Zhao D., Free PMC Article | 07/10/2021 |
| Long noncoding RNA PENG upregulates PDZK1 expression by sponging miR-15b to suppress clear cell renal cell carcinoma cell proliferation. | Long noncoding RNA PENG upregulates PDZK1 expression by sponging miR-15b to suppress clear cell renal cell carcinoma cell proliferation.
Qi Y, Ma Y, Peng Z, Wang L, Li L, Tang Y, He J, Zheng J. | 12/5/2020 |
| Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin. | Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin.
Hernando B, Ibarrola-Villava M, Oltra SS, Valcuende-Cavero F, Pitarch G, Mahiques L, Ribas G, Martinez-Cadenas C. | 06/6/2020 |
| Low levels of PDZK1 in gastric cancer specimens lead to increase proliferation of gastric cancer cells via phosphorylation of PTEN at the S380/T382/T383 cluster and constitutively activation of PI3K/AKT signaling, which results in poor prognosis of gastric cancer patients. | Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer.
Zhao C, Tao T, Yang L, Qin Q, Wang Y, Liu H, Song R, Yang X, Wang Q, Gu S, Xiong Y, Zhao D, Wang S, Feng D, Jiang WG, Zhang J, He J. | 03/28/2020 |
| Results find that PDZK1 has a defined, extended, and L-shaped conformation in solution. The non-PDZ regions of PDZK1 play a key role in supporting a defined conformation; the fourth PDZ domain of PDZK1 also binds to the C terminus of PEPT2. | Probing the Architecture of a Multi-PDZ Domain Protein: Structure of PDZK1 in Solution.
Hajizadeh NR, Pieprzyk J, Skopintsev P, Flayhan A, Svergun DI, Löw C. | 09/28/2019 |
| LXRalpha and PXR are transcriptional regulators of PDZK1. | The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1.
Ferreira C, Meyer R, Meyer Zu Schwabedissen HE. | 08/31/2019 |
| Results indicate that the SMCT1-PDZK1 interaction thus plays an important role in both lactate handling as well as urate reabsorption in the human kidney. | Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12).
Srivastava S, Nakagawa K, He X, Kimura T, Fukutomi T, Miyauchi S, Sakurai H, Anzai N., Free PMC Article | 06/1/2019 |
| the decreased expression of PDZK1 induced by IL-1beta, which is dependent on the NF-kappaB pathway, could account for the imbalance between the functions and expressions of ABCG2 on this status. | IL-1β functionally attenuates ABCG2 and PDZK1 expression in HK-2 cells partially through NF-ĸB activation.
Lu X, Chen M, Shen J, Xu Y, Wu H. | 06/1/2019 |
| Pdzk1 protein level was also reduced in the spermatozoa in case of asthenozoospermic patients compared with that in normozoospermic men, suggesting that Pdzk1 may participate in sperm maturation regulation and may be associated with male infertility. | The expression of the new epididymal luminal protein of PDZ domain containing 1 is decreased in asthenozoospermia.
Liang AJ, Wang GS, Ping P, Hu SG, Lin Y, Ma Y, Duan ZZ, Wang HS, Sun F., Free PMC Article | 05/18/2019 |
| Our and other data predict that the urate-raising T allele of rs1967017 enhances HNF4A binding to the PDZK1 promoter, thereby increasing PDZK1 expression. As PDZK1 is a scaffold protein for many ion channel transporters, increased expression can be predicted to increase activity of urate transporters and alter excretion of urate. | A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expression.
Ketharnathan S, Leask M, Boocock J, Phipps-Green AJ, Antony J, O'Sullivan JM, Merriman TR, Horsfield JA. | 05/11/2019 |
| transactivation of the PDZK1-promoter by triiodothyronine mediated by thyroid hormone receptors (THR) alpha and beta. | PDZ domain containing protein 1 (PDZK1), a modulator of membrane proteins, is regulated by the nuclear receptor THRβ.
Ferreira C, Prestin K, Hussner J, Zimmermann U, Meyer Zu Schwabedissen HE. | 02/16/2019 |
| PDZK1 directly interacts with OATP2B1 resulting in a change of the amount of transporter in the membrane, and thereby in an increased transport function. | The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1.
Ferreira C, Hagen P, Stern M, Hussner J, Zimmermann U, Grube M, Meyer Zu Schwabedissen HE. | 10/20/2018 |
| These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity | PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation.
Tao T, Yang X, Zheng J, Feng D, Qin Q, Shi X, Wang Q, Zhao C, Peng Z, Liu H, Jiang WG, He J. | 11/25/2017 |
| HNF1alpha, which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription. | Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1α (HNF1α) in human kidney.
Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE. | 10/21/2017 |
| a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis) | Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population.
Higashino T, Matsuo H, Sakiyama M, Nakayama A, Nakamura T, Takada T, Ogata H, Kawamura Y, Kawaguchi M, Naito M, Kawai S, Takada Y, Ooyama H, Suzuki H, Shinomiya N. | 03/18/2017 |
| PDZK1 was defined as an independent prognostic factor for both OS and DFS. These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC. | Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma.
Zheng J, Wang L, Peng Z, Yang Y, Feng D, He J., Free PMC Article | 02/18/2017 |
| Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine. | Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis.
Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, Lünnemann M, Goldstein J, Singh AK, Riederer B, Bachmann O, Bleich A, Gereke M, Bruder D, Hagen S, He P, Yun C, Seidler U., Free PMC Article | 04/16/2016 |