Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway. | Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway. Liu SJ, Zang YW, Huang CJ, Liu YJ., Free PMC Article | 02/6/2024 |
Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells. | Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells. Yang E, Hong Y, Xuan C, Xu J, Ding Q, Zhao S, Ye H, Fan X, Jiang Z, Zhang S, Ding X. | 12/20/2023 |
Expansion of the phenotypic and mutational spectrum of Carpenter syndrome. | Expansion of the phenotypic and mutational spectrum of Carpenter syndrome. Khairat R, Elhossini R, Sobreira N, Wohler E, Otaify G, Mohamed AM, Abdel Raouf ER, Sayed I, Aglan M, Ismail S, Temtamy SA. | 03/12/2022 |
miR3673p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells. | miR‑367‑3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells. Du W, Li D, Xie J, Tang P., Free PMC Article | 12/25/2021 |
miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cells by targeting RAB23. | miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cells by targeting RAB23. Wen HL, Xu ZM, Lin SY, Wen D, Xie JP. | 10/23/2021 |
Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-beta Signaling. | Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-β Signaling. Zhang L, Zhang B, You W, Li P, Kuang Y. | 01/16/2021 |
RAB family small GTP binding protein RAB 23 (Rab23) and ADP-ribosylation factor-like 13B (Arl13b) have been implicated in ciliopathy-associated human diseases and could regulate hedgehog proteins (Hh) signalling cascade in multifaceted manners [Review]. | Small GTPases in hedgehog signalling: emerging insights into the disease mechanisms of Rab23-mediated and Arl13b-mediated ciliopathies. Hor CH, Goh EL. | 07/11/2020 |
OSER1-AS1 acted as a ceRNA to sponge miR-372-3p, thereby positively regulating the Rab23 expression and ultimately acting as a tumor suppressor gene in hepatocellular carcinoma progression | lncRNA OSER1-AS1 acts as a ceRNA to promote tumorigenesis in hepatocellular carcinoma by regulating miR-372-3p/Rab23 axis. Fan J, Zhang J, Huang S, Li P. | 07/11/2020 |
miR-16 acts as a tumor repressor in osteosarcoma cells by reducing epithelial mesenchymal transition, migration and invasion by targeting RAB23 expression. | MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23. Jiao ZH, Wang JD, Wang XJ. | 12/14/2019 |
Genetic variants in RAB23 and ANXA11 genes were associated with an increased risk of sarcoidosis-associated uveitis. | Association of genetic variants in RAB23 and ANXA11 with uveitis in sarcoidosis. Davoudi S, Chang VS, Navarro-Gomez D, Stanwyck LK, Sevgi DD, Papavasileiou E, Ren A, Uchiyama E, Sullivan L, Lobo AM, Papaliodis GN, Sobrin L., Free PMC Article | 11/17/2018 |
miR-429 was down-regulated in hepatocellular carcinoma (HCC) tissues and cells. Up regulation of miR-429 decreased the migratory capacity and reversed the EMT to MET in HCC cells. RAB23 was confirmed as a target of miR-429. | MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23. Xue H, Tian GY. | 01/6/2018 |
Down-regulation of Rab23 suppressed the proliferation, migration and invasion of prostate cancer cells. | Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo. Chang J, Xu W, Liu G, Du X, Li X., Free PMC Article | 03/18/2017 |
Rab23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through Rac1 activity | Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1. Wang M, Dong Q, Wang Y. | 02/18/2017 |
High Rab23 expression is associated with bladder cancer. | Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion. Jiang Y, Han Y, Sun C, Han C, Han N, Zhi W, Qiao Q. | 02/18/2017 |
Forced expression of MiR-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in esophageal squamous cell carcinoma, suggesting RAB23 might be a therapeutic target | RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma. Cheng L, Yang F, Zhou B, Yang H, Yuan Y, Li X, Han S. | 01/28/2017 |
Rab23 enhance squamous cell carcinoma cell invasion via up-regulating Rac1. | [Rab23 enhances invasion of Sa3 cutaneous squamous cell carcinoma cells via up-regulating the expression of Rac1]. Miao Y, Jian Q, Zhang M, Li C. | 07/2/2016 |
Rab23 is expressed in breast cancer cells, and ectopic expression of Rab23 inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 of Gli1 and Gli2 mRNA expression | Effect of Rab23 on the proliferation and apoptosis in breast cancer. Liu Y, Zeng C, Bao N, Zhao J, Hu Y, Li C, Chi S. | 06/11/2016 |
Data indicate the essential role of GTP binding protein RAB 23 (Rab23) in pancreatic ductal adenocarcinoma (PDAC) inva-sion, motility and metastasis. | Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma. Cai ZZ, Xu LB, Cai JL, Wang JS, Zhou B, Hu H. | 01/16/2016 |
Rab23 was a target gene of miR-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR-367. | The microRNA-367 inhibits the invasion and metastasis of gastric cancer by directly repressing Rab23. Bin Z, Dedong H, Xiangjie F, Hongwei X, Qinghui Y. | 10/24/2015 |
The inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1. | Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines. Sun HJ, Liu YJ, Li N, Sun ZY, Zhao HW, Wang C, Li H, Ma FM, Shi SM, Xu XQ, Chen ZY, Huang SH. | 03/1/2014 |
Rab23 expression level was the highest in Bcap-37 cells. | [Role of Rab23 in invasion and migration of human breast cancer Bcap-37 cells]. Zhao J, Liu Y, Jian Q, Li J, Chi S. | 11/16/2013 |
Rab9A and Rab23 GTPases play crucial roles in autophagy of Group A Streptococcus. | The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Nozawa T, Aikawa C, Goda A, Maruyama F, Hamada S, Nakagawa I. | 11/24/2012 |
Rab23 directly associates with Su(Fu) and inhibits Gli1 function in a Su(Fu)-dependent manner. | Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner. Chi S, Xie G, Liu H, Chen K, Zhang X, Li C, Xie J., Free PMC Article | 07/28/2012 |
association of the 6p12.1 locus with sarcoidosis implicates this locus as a further susceptibility factor and RAB23 as a potential signalling component | A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1. Hofmann S, Fischer A, Till A, Müller-Quernheim J, Häsler R, Franke A, Gäde KI, Schaarschmidt H, Rosenstiel P, Nebel A, Schürmann M, Nothnagel M, Schreiber S, GenPhenReSa Consortium. | 06/23/2012 |
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay | Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay. Jenkins D, Baynam G, De Catte L, Elcioglu N, Gabbett MT, Hudgins L, Hurst JA, Jehee FS, Oley C, Wilkie AO., Free PMC Article | 07/23/2011 |