| Developmental, Cognitive, Ocular Motor, and Neuroimaging Findings Related to SUFU Haploinsufficiency: Unraveling Subtle and Highly Variable Phenotypes. | Developmental, Cognitive, Ocular Motor, and Neuroimaging Findings Related to SUFU Haploinsufficiency: Unraveling Subtle and Highly Variable Phenotypes.
Siegert S, Grisold A, Pal-Handl K, Lilja S, Kepa S, Silvaieh S, Laccone F, Wiest G, Pogledic I, Schmook MT, Boltshauser E, Schmidt WM, Krenn M. | 10/29/2024 |
| WNT5A, betacatenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction. | WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction.
Sola IM, Karin-Kujundzic V, Paic F, Lijovic L, Glibo M, Serman N, Duic T, Skrtic A, Kuna K, Vranic S, Serman L., Free PMC Article | 12/24/2022 |
| ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1. | ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1.
Bardwell AJ, Wu B, Sarin KY, Waterman ML, Atwood SX, Bardwell L., Free PMC Article | 07/30/2022 |
| SUFU mediates EMT and Wnt/beta-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer. | SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer.
Peng Y, Zhang X, Lin H, Deng S, Qin Y, Yuan Y, Feng X, Wang J, Chen W, Hu F, Yan R, Zhao Y, Cheng Y, Wei Y, Fan X, Ashktorab H, Smoot D, Li S, Meltzer SJ, Jin Z., Free PMC Article | 12/11/2021 |
| Sufu negatively regulates both initiations of centrosome duplication and DNA replication. | Sufu negatively regulates both initiations of centrosome duplication and DNA replication.
Zhuang T, Zhang B, Song Y, Huang F, Chi W, Xin G, Zhang Z, Cheng SY, Jiang Q, Zhang C., Free PMC Article | 12/4/2021 |
| Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma. | Differences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma.
Gershanov S, Toledano H, Pernicone N, Fichman S, Michowiz S, Pinhasov A, Goldenberg-Cohen N, Listovsky T, Salmon-Divon M., Free PMC Article | 12/4/2021 |
| Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia. | Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia.
Schröder S, Li Y, Yigit G, Altmüller J, Bader I, Bevot A, Biskup S, Dreha-Kulaczewski S, Christoph Korenke G, Kottke R, Mayr JA, Preisel M, Toelle SP, Wente-Schulz S, Wortmann SB, Hahn H, Boltshauser E, Uhmann A, Wollnik B, Brockmann K., Free PMC Article | 07/10/2021 |
| The Twist1-regulated miR-214 promotes the activation of Hepatic stellate cells through targeting Sufu involved in the Hedgehog pathway and participates in the development of hepatic fibrosis. Hence, the knockdown of miR-214 expression may be a promising therapeutic strategy for liver fibrosis. | MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression.
Ma L, Yang X, Wei R, Ye T, Zhou JK, Wen M, Men R, Li P, Dong B, Liu L, Fu X, Xu H, Aqeilan RI, Wei YQ, Yang L, Peng Y., Free PMC Article | 12/7/2019 |
| Germline SUFU mutations are associated with medulloblastoma. | Germline SUFU mutation carriers and medulloblastoma: clinical characteristics, cancer risk, and prognosis.
Guerrini-Rousseau L, Dufour C, Varlet P, Masliah-Planchon J, Bourdeaut F, Guillaud-Bataille M, Abbas R, Bertozzi AI, Fouyssac F, Huybrechts S, Puget S, Bressac-De Paillerets B, Caron O, Sevenet N, Dimaria M, Villebasse S, Delattre O, Valteau-Couanet D, Grill J, Brugières L., Free PMC Article | 10/5/2019 |
| establishes the dual role of SUFU inSonic Hedgehog medulloblastoma (MB) and provides mechanistic insights into transcriptional regulation underlying Gli2-mediated SHH MB tumorigenesis | Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.
Yin WC, Satkunendran T, Mo R, Morrissy S, Zhang X, Huang ES, Uusküla-Reimand L, Hou H, Son JE, Liu W, Liu YC, Zhang J, Parker J, Wang X, Farooq H, Selvadurai H, Chen X, Ngan ES, Cheng SY, Dirks PB, Angers S, Wilson MD, Taylor MD, Hui CC. | 08/3/2019 |
| MiR-423-5p enriched exosomes could be internalized into gastric cancer cells, which enhanced cell proliferation and migration both in vitro and in vivo. Mechanistically, miR-423-5p inhibited the expression of suppressor of fused protein (SUFU) to enhance the proliferation and migration of gastric cancer cells. The expression levels of SUFU were significantly decreased in gastric cancer cells and the tumor tissues. | Exosomal miR-423-5p targets SUFU to promote cancer growth and metastasis and serves as a novel marker for gastric cancer.
Yang H, Fu H, Wang B, Zhang X, Mao J, Li X, Wang M, Sun Z, Qian H, Xu W. | 04/27/2019 |
| A novel SUFU splice site deleterious genetic variant in cutaneous cancer predisposition syndrome. | Mutations in SUFU and PTCH1 genes may cause different cutaneous cancer predisposition syndromes: similar, but not the same.
Huq AJ, Walsh M, Rajagopalan B, Finlay M, Trainer AH, Bonnet F, Sevenet N, Winship IM. | 03/9/2019 |
| miR-194 was highly expressed in gastric cancer (GC) tissues, whereas SUFU was downregulated in GC tissues and cell lines, thus suggesting that miR-194 may be a carcinogenic miRNA, whereas SUFU may act as a tumor suppressor. | Inhibition of miR‑194 suppresses the Wnt/β‑catenin signalling pathway in gastric cancer.
Peng Y, Zhang X, Lin H, Deng S, Huang Y, Qin Y, Feng X, Yan R, Zhao Y, Cheng Y, Wei Y, Wang J, Chen W, Fan X, Ashktorab H, Smoot D, Meltzer SJ, Li S, Zhang Z, Jin Z., Free PMC Article | 01/12/2019 |
| Down-regulation of microRNA-224 inhibits growth and epithelial-to-mesenchymal transition phenotype via modulating SUFU expression in bladder cancer cells. | Down-regulation of microRNA-224 -inhibites growth and epithelial-to-mesenchymal transition phenotype -via modulating SUFU expression in bladder cancer cells.
Miao X, Gao H, Liu S, Chen M, Xu W, Ling X, Deng X, Rao C. | 07/7/2018 |
| Itch/beta-arrestin2 complex binds SuFu and induces its Lys63-linked polyubiquitylation without affecting its stability. | Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.
Infante P, Faedda R, Bernardi F, Bufalieri F, Lospinoso Severini L, Alfonsi R, Mazzà D, Siler M, Coni S, Po A, Petroni M, Ferretti E, Mori M, De Smaele E, Canettieri G, Capalbo C, Maroder M, Screpanti I, Kool M, Pfister SM, Guardavaccaro D, Gulino A, Di Marcotullio L., Free PMC Article | 05/19/2018 |
| Patients with SUFU pathogenic variants were significantly more likely to develop a medulloblastoma, a meningioma or an ovarian fibroma, but were less likely to develop a jaw cyst. | First evidence of genotype-phenotype correlations in Gorlin syndrome.
Evans DG, Oudit D, Smith MJ, Rutkowski D, Allan E, Newman WG, Lear JT. | 04/7/2018 |
| Nek2A is found to stabilize SuFu at least partly depending on its kinase activity, thereby triggering phosphorylation of the SuFu protein. | Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism.
Wang Y, Li Y, Hu G, Huang X, Rao H, Xiong X, Luo Z, Lu Q, Luo S. | 12/2/2017 |
| Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. | Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L., Free PMC Article | 10/28/2017 |
| Missense mutation in SUFU gene is associated with Joubert Syndrome with Cranio-facial and Skeletal Defects. | Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.
De Mori R, Romani M, D'Arrigo S, Zaki MS, Lorefice E, Tardivo S, Biagini T, Stanley V, Musaev D, Fluss J, Micalizzi A, Nuovo S, Illi B, Chiapparini L, Di Marcotullio L, Issa MY, Anello D, Casella A, Ginevrino M, Leggins AS, Roosing S, Alfonsi R, Rosati J, Schot R, Mancini GMS, Bertini E, Dobyns WB, Mazza T, Gleeson JG, Valente EM., Free PMC Article | 10/21/2017 |
| In conclusion, this study showed the potential of miR-342-3p as a therapeutic target to promote bone regeneration by modulating expression of Sufu in UCMSCs. | miR-342-3p elevates osteogenic differentiation of umbilical cord mesenchymal stem cells via inhibiting Sufu in vitro.
Huang M, Qing Y, Shi Q, Cao Y, Song K. | 09/16/2017 |
| miRNA-194 is oncogenic and promotes gastric cancer cell proliferation and migration by activating Wnt signaling, at least in part, via suppression of SUFU. | MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU.
Peng Y, Zhang X, Ma Q, Yan R, Qin Y, Zhao Y, Cheng Y, Yang M, Wang Q, Feng X, Huang Y, Huang W, Zhao Z, Wang L, Wei Y, He Z, Fan X, Li S, Jin Z, Meltzer SJ. | 08/12/2017 |
| SUFU's role in Hedgehog signaling, tumor progression, and highlight a way in which BCCs can arise | Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions.
Urman NM, Mirza A, Atwood SX, Whitson RJ, Sarin KY, Tang JY, Oro AE., Free PMC Article | 07/8/2017 |
| In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. | SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thézénas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgård R, D'Angiolella V., Free PMC Article | 07/1/2017 |
| there was a positive correlation between VDR status and the expression of Suppressor of fused gene (SuFu), a hedgehog pathway inhibitor. miR-214 on the other hand suppressed SuFu protein expression. | Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells.
Alimirah F, Peng X, Gupta A, Yuan L, Welsh J, Cleary M, Mehta RG. | 05/20/2017 |
| The data indicate that there exists a novel transcript variant of SUFU which can be transcribed and translated into corresponding protein and its transcription is related with metastasis of lymph nodes in pancreatic ductal adenocarcinoma. | Identification of a novel alternative splicing transcript variant of the suppressor of fused: Relationship with lymph node metastasis in pancreatic ductal adenocarcinoma.
Xu Q, Gao J, Li Z. | 04/22/2017 |