| Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis. | Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis.
Gong J, Du C, Sun N, Xiao X, Wu H. | 01/22/2022 |
| PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma. | PDK2 leads to cisplatin resistance through suppression of mitochondrial function in ovarian clear cell carcinoma.
Kitamura S, Yamaguchi K, Murakami R, Furutake Y, Higasa K, Abiko K, Hamanishi J, Baba T, Matsumura N, Mandai M., Free PMC Article | 11/27/2021 |
| Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia. | Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia.
Cui L, Cheng Z, Liu Y, Dai Y, Pang Y, Jiao Y, Ke X, Cui W, Zhang Q, Shi J, Fu L. | 05/15/2021 |
| [Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation]. | [Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].
Chen HL, Cui BM, Kang YZ, Wang LW, Wang JN, Feng Y, Zhang P, Lü D, Chen J. | 12/26/2020 |
| we identified PDK2 as the most up-regulated kinase encoding gene in Cisplatin resistant lung adenocarcinoma and PDK2-dependent Cisplatin-resistance promotes tumour growth of lung adenocarcinoma mainly through transcriptional regulation of CNNM3 | PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3.
Hu T, Yu S, Li Y, Ren H, Ning Q, Wang J, Liang X, Li M. | 08/1/2020 |
| MiR-422a regulates cellular metabolism and malignancy by targeting PDK2 in gastric cancer. | MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer.
He Z, Li Z, Zhang X, Yin K, Wang W, Xu Z, Li B, Zhang L, Xu J, Sun G, Wang L, Li Q, Huang X, Zhang L, Zhang D, Xu H, Xu Z., Free PMC Article | 11/30/2019 |
| PDK2/PARL senses defects in mitochondrial bioenergetics. | The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism.
Shi G, McQuibban GA. | 12/2/2017 |
| The data demonstrate potential roles of PDK2 and ABCG2 polymorphisms in the metabolic phenotypes of Tibetan gout patients. | PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients.
Ren YC, Jin TB, Sun XD, Geng TT, Zhang MX, Wang L, Feng T, Kang LL, Chen C. | 11/12/2016 |
| High glycolysis and PDK2 overexpression are closely linked to cisplatin resistance in head and neck cancer cells, which can be reversed by PDK2 nhibition. | Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer.
Roh JL, Park JY, Kim EH, Jang HJ, Kwon M. | 05/21/2016 |
| both PDK 1 and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR pathway effectors and independent of the BRAF mutational status | Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy.
Pópulo H, Caldas R, Lopes JM, Pardal J, Máximo V, Soares P. | 01/16/2016 |
| The findings of the present study reveal a novel survival pathway that functionally couples the unique glycolytic phenotype in cancer cells to hypoxia resistance via a PDK2-dependent mechanism that switches Bnip3 from cell death to survival. | PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival.
Gang H, Dhingra R, Lin J, Hai Y, Aviv Y, Margulets V, Hamedani M, Thanasupawat T, Leygue E, Klonisch T, Davie JR, Kirshenbaum LA., Free PMC Article | 12/26/2015 |
| The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2. | Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.
Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT., Free PMC Article | 05/3/2014 |
| Germline mutations in PKD2 gene is associated with autosomal-dominant polycystic kidney disease. | Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany.
Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B, Hoffmann MM, Ortiz-Bruechle N, Glasker S, Pisarski P, Neeff H, Krämer-Guth A, Cybulla M, Hornberger M, Wilpert J, Funk L, Baumert J, Paatz D, Baumann D, Lahl M, Felten H, Hausberg M, Zerres K, Eng C, Else-Kroener-Fresenius-ADPKD-Registry. | 01/25/2014 |
| we for the first time demonstrated that a low-nutrient condition drives cancer cells to utilize glycolysis to produce ATP, and this increases the Warburg effect through a novel mechanism involving ROS/AMPK-dependent activation of PDK. | Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase.
Wu CA, Chao Y, Shiah SG, Lin WW. | 06/22/2013 |
| Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer. | Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.
Sutendra G, Dromparis P, Kinnaird A, Stenson TH, Haromy A, Parker JM, McMurtry MS, Michelakis ED. | 05/25/2013 |
| Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species. | Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.
Hurd TR, Collins Y, Abakumova I, Chouchani ET, Baranowski B, Fearnley IM, Prime TA, Murphy MP, James AM., Free PMC Article | 01/5/2013 |
| Results established that wild-type p53 prevents manifestation of the Warburg effect by controlling Pdk2. These findings elucidate a new mechanism by which p53 suppresses tumorigenesis acting at the level of cancer cell metabolism. | p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
Contractor T, Harris CR. | 04/14/2012 |
| PKD2 mutations are associated with autosomal dominant polycystic kidney disease. | Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD).
Hoefele J, Mayer K, Scholz M, Klein HG. | 11/5/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| the DW-motif has a pivotal role in mediating communications between the DCA-, the nucleotide-, and the lipoyl domain-binding sites of PDK2 | Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.
Li J, Kato M, Chuang DT., Free PMC Article | 01/21/2010 |
| mitochondrial ND2 mutation contributes to HIF1alpha accumulation via increased ROS production, up-regulation of PDK2, attenuating PDH activity, thereby increasing pyruvate, resulting in HIF1alpha stabilization | Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.
Sun W, Zhou S, Chang SS, McFate T, Verma A, Califano JA., Free PMC Article | 01/21/2010 |
| PKD1 children have more and larger renal cysts, larger kidneys and higher ambulatory BP than do PKD2 children. | Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease.
Fencl F, Janda J, Bláhová K, Hríbal Z, Stekrová J, Puchmajerová A, Seeman T. | 01/21/2010 |
| Pi is suggested to facilitate transmission within PDHK2 of the stimulatory signal of acetylation from the distal lipoyl-group binding site to the active site. | Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.
Hiromasa Y, Yan X, Roche TE. | 01/21/2010 |
| Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2. | Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.
Hiromasa Y, Roche TE. | 01/21/2010 |
| PDK2, PDK3 and PDK4 are primary PPARbeta/delta target genes in humans underlining the importance of the receptor in the control of metabolism | Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
Degenhardt T, Saramäki A, Malinen M, Rieck M, Väisänen S, Huotari A, Herzig KH, Müller R, Carlberg C. | 01/21/2010 |