| Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-beta-dependent cell metabolism in human lung adenocarcinoma A549 cells. | Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
Arai W, Konno T, Kohno T, Kodera Y, Tsujiwaki M, Shindo Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T., Free PMC Article | 03/28/2023 |
| LSR Promotes Cell Proliferation and Invasion in Lung Cancer. | LSR Promotes Cell Proliferation and Invasion in Lung Cancer.
Zhang M, Ma C., Free PMC Article | 09/11/2021 |
| Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition. | Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
Kohno T, Konno T, Kikuchi S, Kondoh M, Kojima T. | 09/11/2021 |
| Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer. | Potentiation of cancerous progression by LISCH7 via direct stimulation of TGFB1 transcription in triple-negative breast cancer.
Tang X, Zhou Y, Liu Y, Zhang W, Liu C, Yan C. | 08/7/2021 |
| LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway. | LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway.
Takahashi Y, Serada S, Ohkawara T, Fujimoto M, Hiramatsu K, Ueda Y, Kimura T, Takemori H, Naka T. | 04/24/2021 |
| Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3. | Leptin Downregulates Angulin-1 in Active Crohn's Disease via STAT3.
Hu JE, Bojarski C, Branchi F, Fromm M, Krug SM., Free PMC Article | 04/24/2021 |
| HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells. | HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
Kodera Y, Chiba H, Konno T, Kohno T, Takahashi H, Kojima T. | 01/9/2021 |
| ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer. | ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
Konno T, Kohno T, Okada T, Shimada H, Satohisa S, Kikuchi S, Saito T, Kojima T. | 01/2/2021 |
| Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells. | Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
Konno T, Kohno T, Kikuchi S, Shimada H, Satohisa S, Takano K, Saito T, Kojima T., Free PMC Article | 08/15/2020 |
| In pancreatic cancer, LSR contributes to the epithelial barrier and malignancy via growth factors and may be a potential targeting molecule in the therapy. | Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.
Kyuno T, Kyuno D, Kohno T, Konno T, Kikuchi S, Arimoto C, Yamaguchi H, Imamura M, Kimura Y, Kondoh M, Takemasa I, Kojima T. | 02/15/2020 |
| These results highlight the importance of the LSR polymorphism and reveal the existence of complex molecular links between LSR and ApoE for the regulation of lipid levels, revealing potential new pathways of interest in type III hyperlipidemia and its involvement in cardiovascular disease pathology. | Effect of LSR polymorphism on blood lipid levels and age-specific epistatic interaction with the APOE common polymorphism.
Xie T, Stathopoulou MG, Akbar S, Oster T, Siest G, Yen FT, Visvikis-Siest S. | 10/5/2019 |
| In the salivary gland ducts from patients with IgG4-related disease there was significant infiltration of IgG-positive plasma cells, and expression of GBP-1, CLDN-7 and LSR was increased. | Guanylate binding protein-1-mediated epithelial barrier in human salivary gland duct epithelium.
Konno T, Takano K, Kaneko Y, Kakuki T, Nomura K, Yajima R, Kakiuchi A, Kohno T, Himi T, Kojima T. | 09/21/2019 |
| Study found a significant epistatic interaction between APOE and two lipolysis-stimulated lipoprotein receptor (LSR) variants, rs34259399 and rs916147. Interestingly, the interaction of LSR polymorphisms with APOE non-epsilon4 alleles increased Alzheimer Disease risk. | Epistatic interaction of apolipoprotein E and lipolysis-stimulated lipoprotein receptor genetic variants is associated with Alzheimer's disease.
Xie T, Akbar S, Stathopoulou MG, Oster T, Masson C, Yen FT, Visvikis-Siest S. | 05/25/2019 |
| this study shows that loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in endometrial cancer | Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.
Shimada H, Abe S, Kohno T, Satohisa S, Konno T, Takahashi S, Hatakeyama T, Arimoto C, Kakuki T, Kaneko Y, Takano KI, Saito T, Kojima T., Free PMC Article | 10/27/2018 |
| Lipolysis-stimulated lipoprotein receptor (LSR)-deficient CaCo-2 cells exhibited increased cell proliferation. | Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells.
Czulkies BA, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, Lassmann S, Zeiser R, Aktories K, Papatheodorou P., Free PMC Article | 03/24/2018 |
| Results of this study provide novel evidence that tricellular tight junctions protein LSR negatively regulates cancer cell progression and development in endometrial cancer. | The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells.
Shimada H, Satohisa S, Kohno T, Takahashi S, Hatakeyama T, Konno T, Tsujiwaki M, Saito T, Kojima T., Free PMC Article | 12/16/2017 |
| Lipolysis-stimulated lipoprotein receptors (LSRs) localized to bicellular junctions in association with myosin regulatory light chain 2 (MRLC2) at low cell densities and to tricellular contacts when myosin phosphatase target subunit 1 (MYPT1) localized to the bicellular regions. | The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions.
Kohno T, Kikuchi S, Ninomiya T, Kojima T. | 08/26/2017 |
| analysis of how Clostridium difficile binary toxin CDT interacts with its host cell receptor, Lipolysis-stimulated Lipoprotein Receptor | Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR).
Hemmasi S, Czulkies BA, Schorch B, Veit A, Aktories K, Papatheodorou P., Free PMC Article | 08/22/2015 |
| These data show that Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts. | Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts.
Papatheodorou P, Hornuss D, Nölke T, Hemmasi S, Castonguay J, Picchianti M, Aktories K., Free PMC Article | 11/30/2013 |
| findings show that Clostridium spiroforme toxin (CST)enters target cells via the lipolysis-stimulated lipoprotein receptor; findings indicate that CST shares LSR with C. difficile CDT and C. perfringens iota toxin as a host cell surface receptor | Identification of the cellular receptor of Clostridium spiroforme toxin.
Papatheodorou P, Wilczek C, Nölke T, Guttenberg G, Hornuss D, Schwan C, Aktories K., Free PMC Article | 05/12/2012 |
| LSR defines tricellular contacts in epithelial cellular sheets by acting as a landmark to recruit tricellulin for tricellular tight junction formation. | LSR defines cell corners for tricellular tight junction formation in epithelial cells.
Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E, Furuse M. | 06/25/2011 |
| LISCH7 may have a role in progression of human colon cancer | Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients.
García JM, Peña C, García V, Domínguez G, Muñoz C, Silva J, Millán I, Diaz R, Lorenzo Y, Rodriguez R, Bonilla F. | 01/21/2010 |