| Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research. | Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research.
Naser IH, Hamza AA, Alhili A, Faisal AN, Ali MS, Kadhim NA, Suliman M, Alshahrani MY, Alawadi A. | 04/24/2024 |
| Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension. | Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
Jiang CY, Wu LW, Liu YW, Feng B, Ye LC, Huang X, He YY, Shen Y, Zhu YF, Zhou XL, Jiang DJ, Qi HK, Zhang H, Yan Y., Free PMC Article | 09/9/2023 |
| Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. | Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C. | 02/26/2022 |
| The relation between ACKR4 and CCR7 genes expression and breast cancer metastasis. | The relation between ACKR4 and CCR7 genes expression and breast cancer metastasis.
Mohammed MM, Shaker O, Ramzy MM, Gaber SS, Kamel HS, Abed El Baky MF. | 07/10/2021 |
| Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings. | Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings.
Lewandowska P, Wierzbicki J, Zawadzki M, Agrawal A, Krzystek-Korpacka M., Free PMC Article | 06/26/2021 |
| ACKR4 Recruits GRK3 Prior to beta-Arrestins but Can Scavenge Chemokines in the Absence of beta-Arrestins. | ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.
Matti C, Salnikov A, Artinger M, D'Agostino G, Kindinger I, Uguccioni M, Thelen M, Legler DF., Free PMC Article | 04/3/2021 |
| Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22. | Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.
Meyrath M, Reynders N, Uchański T, Chevigné A, Szpakowska M. | 03/27/2021 |
| CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4. | CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
Matti C, D'Uonnolo G, Artinger M, Melgrati S, Salnikov A, Thelen S, Purvanov V, Strobel TD, Spannagel L, Thelen M, Legler DF. | 11/21/2020 |
| CCL19-mRFP and CCL21-mRFP are versatile and powerful tools to study CCR7 and ACKR4 functions. | Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions.
Purvanov V, Matti C, Samson GPB, Kindinger I, Legler DF., Free PMC Article | 03/30/2019 |
| Results of this study show that HEK 293 cells express an endogenous CCRL1 gene only at mRNA level. These data therefore represent the important implications for the use of HEK 293 cells as a host cell system for the study of CCX-CKR. | Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells.
Salimi P, Esmaeili A, Hashemi M, Behjati M. | 11/5/2016 |
| we found that CCX-CKR expression in vitro could modulate cellular migration and invasion abilities, potentially via the regulation of other chemotactic factors/receptors. | CCX-CKR expression in colorectal cancer and patient survival.
Zhu Y, Tang W, Liu Y, Wang G, Liang Z, Cui L. | 11/22/2014 |
| Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer. | Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer.
Yang C, Yu KD, Xu WH, Chen AX, Fan L, Ou ZL, Shao ZM., Free PMC Article | 07/12/2014 |
| co-expression of DARC, D6, and CCX-CKR significantly associated with higher survival in gastric cancer | Prognostic impact of atypical chemokine receptor expression in patients with gastric cancer.
Zhu Z, Sun Z, Wang Z, Guo P, Zheng X, Xu H. | 08/31/2013 |
| Data suggest that co-expression of CCX-CKR and CXCR3 (chemokine receptor type 3) in T-lymphocytes results in protein multimerization and prevents CXCR3-mediated chemotaxis; this represents a novel mechanism of regulation of immune cell migration. | Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.
Vinet J, van Zwam M, Dijkstra IM, Brouwer N, van Weering HR, Watts A, Meijer M, Fokkens MR, Kannan V, Verzijl D, Vischer HF, Smit MJ, Leurs R, Biber K, Boddeke HW., Free PMC Article | 08/31/2013 |
| Results suggest that chemokine binding to CCX-CKR recruits Gi proteins and beta-arrestin (beta-arr) with high affinity. | β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.
Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ, Vischer HF., Free PMC Article | 05/4/2013 |
| Down regulation of CCX-CKR is associated with breast cancer. | Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival.
Feng LY, Ou ZL, Wu FY, Shen ZZ, Shao ZM. | 01/21/2010 |
| Scavenges extracellular chemokines in vivo to modify responses through CCR7. | The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro.
Comerford I, Milasta S, Morrow V, Milligan G, Nibbs R. | 01/21/2010 |
| Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. | Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.
Townson JR, Nibbs RJ. | 01/21/2010 |