| Loss-of-function mutation of REV1 (p.R704Q) mediates cetuximab primary resistance by activating autophagy in RAS-wild type metastatic colorectal cancer. | Loss-of-function mutation of REV1 (p.R704Q) mediates cetuximab primary resistance by activating autophagy in RAS-wild type metastatic colorectal cancer.
Zhu N, Ding Y, Mi M, Yang J, Yang M, Li D, Zhang Y, Fang X, Weng S, Yuan Y. | 09/24/2024 |
| The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA. | The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA.
Stolyarenko AD, Novikova AA, Shilkin ES, Poltorachenko VA, Makarova AV., Free PMC Article | 05/20/2024 |
| REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis. | REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis.
Chen Y, Jie X, Xing B, Wu Z, Yang X, Rao X, Xu Y, Zhou D, Dong X, Zhang T, Yang K, Li Z, Wu G., Free PMC Article | 04/16/2022 |
| Genetic and physical interactions between Poleta and Rev1 in response to UV-induced DNA damage in mammalian cells. | Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells.
Bi T, Niu X, Qin C, Xiao W., Free PMC Article | 01/29/2022 |
| REV1-Polzeta maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. | REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.
Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A., Free PMC Article | 01/1/2022 |
| Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. | Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs.
Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL., Free PMC Article | 03/13/2021 |
| Exome Sequencing in Individuals with Isolated Biliary Atresia. | Exome Sequencing in Individuals with Isolated Biliary Atresia.
Rajagopalan R, Tsai EA, Grochowski CM, Kelly SM, Loomes KM, Spinner NB, Devoto M., Free PMC Article | 11/21/2020 |
| elevated expression of Rev1 alone is sufficient to confer enhanced UV-damage tolerance and that this tolerance depends on its physical interaction with monoubiquitinated PCNA and Polzeta but is independent of Poleta. | Rev1 plays central roles in mammalian DNA-damage tolerance in response to UV irradiation.
Niu X, Chen W, Bi T, Lu M, Qin Z, Xiao W. | 06/6/2020 |
| Study reports the solution NMR structure of a 108-residue fragment of human REV1 encompassing the two putative ubiquitin-binding motifs UBM1 and UBM2 in complex with ubiquitin. While in mammals UBM1 and UBM2 are both required for optimal association of REV1 with replication factories after DNA damage, only REV1 UBM2 binds ubiquitin. | Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.
Cui G, Botuyan MV, Mer G., Free PMC Article | 06/22/2019 |
| RAD51 regulates REV1 recruitment to DNA double-strand break sites via pulsed laser microirradiation. | [RAD51 regulates REV1 recruitment to DNA double-strand <br/>break sites].
Huang M, Yang YR, Sun XY, Zhang T, Guo CX. | 03/30/2019 |
| results provide insights into the structure of the Rev1/Polzeta TLS assembly and highlight the function of Rev7 homo- and heterodimerization. | Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex.
Rizzo AA, Vassel FM, Chatterjee N, D'Souza S, Li Y, Hao B, Hemann MT, Walker GC, Korzhnev DM., Free PMC Article | 10/6/2018 |
| These data indicate that dysregulation of cellular Rev1 levels leads to the accumulation of mutations and suppression of cell death, which accelerates the tumorigenic activities of DNA-damaging agents. | Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.
Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki K, Kusunoki Y, Zaharieva EK, Kamiya K., Free PMC Article | 09/9/2017 |
| The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase. | Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.
Quinet A, Martins DJ, Vessoni AT, Biard D, Sarasin A, Stary A, Menck CF., Free PMC Article | 06/10/2017 |
| the catalytic function of REV1 is moderately or slightly altered by at least nine genetic variations, and the G4 DNA processing function of REV1 is slightly enhanced by the N373S variation, which might provide the possibility that certain germline missense REV1 variations affect the individual susceptibility to carcinogenesis by modifying the capability of REV1 for replicative bypass past DNA lesions and G4 motifs derived | Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1.
Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY., Free PMC Article | 01/28/2017 |
| REV1 can promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18. | REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18.
Wang Z, Huang M, Ma X, Li H, Tang T, Guo C. | 01/14/2017 |
| Saccharomyces cerevisiae | The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.
Boehm EM, Powers KT, Kondratick CM, Spies M, Houtman JC, Washington MT., Free PMC Article | 10/8/2016 |
| Data suggest that relatively high affinity binding of PolD3-RIR motif to Rev1-C-terminal domain displaces subunits from PolN, Pol-iota, or PolK from Rev1 complex and promotes formation of Rev1/PolZ4 assembly with PCNA for translesion DNA replication. | Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.
Pustovalova Y, Magalhães MT, D'Souza S, Rizzo AA, Korza G, Walker GC, Korzhnev DM., Free PMC Article | 08/27/2016 |
| Rev1 is indispensable for Translesion synthesis mediated by Poleta, Poliota, and Polkappa but is not required for TLS by Polzeta. | Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ.
Yoon JH, Park J, Conde J, Wakamiya M, Prakash L, Prakash S., Free PMC Article | 04/23/2016 |
| Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20). | Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain.
Lim K, Lee MK, Duong PT, Liu D, Sung S, Choi BS. | 01/30/2016 |
| show that REV1 is a novel binding partner of the tumor suppressor p53 and regulates its activity | Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.
Shim HS, Wei M, Brandhorst S, Longo VD., Free PMC Article | 07/25/2015 |
| Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatin-based chemotherapy | Polymorphisms in translesion polymerase genes influence treatment outcome in malignant mesothelioma.
Goričar K, Kovač V, Dolžan V. | 02/14/2015 |
| The molecular mechanism of 3-nitrobenzanthrone genotoxicity in HEK293 cells is reported. | Mutational analysis of the C8-guanine adduct of the environmental carcinogen 3-nitrobenzanthrone in human cells: critical roles of DNA polymerases η and κ and Rev1 in error-prone translesion synthesis.
Pande P, Malik CK, Bose A, Jasti VP, Basu AK., Free PMC Article | 10/18/2014 |
| Structural studies suggest the possible involvement of XRCC1 and its associated repair factors, REV1 in post replication repair. | XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair.
Gabel SA, DeRose EF, London RE., Free PMC Article | 07/19/2014 |
| The results show that human Rev1 disrupts G4 DNA structures and prevents refolding in vitro. | Human Rev1 polymerase disrupts G-quadruplex DNA.
Eddy S, Ketkar A, Zafar MK, Maddukuri L, Choi JY, Eoff RL., Free PMC Article | 05/24/2014 |
| the first structural insights into the regulation of human Rev1 for TLS polymerases. | Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain.
Liu D, Ryu KS, Ko J, Sun D, Lim K, Lee JO, Hwang Jm, Lee ZW, Choi BS. | 02/1/2014 |