| PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2). | PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).
Landry-Voyer AM, Bergeron D, Yague-Sanz C, Baker B, Bachand F., Free PMC Article | 01/16/2021 |
| the present study elucidated for the first time, to the best of our knowledge, that PDCD2 sensitizes sorafenibresistant HepG2 cells to sorafenib by the downregulation of EMT. PDCD2 may serve as a potential therapeutic target in the treatment of sorafenibresistant liver cancer. | PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition.
Liu H, Wang M, Liang N, Guan L., Free PMC Article | 05/25/2019 |
| PDCD2 and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad signaling pathway. | PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.
Wang W, Song XW, Bu XM, Zhang N, Zhao CH. | 12/24/2016 |
| PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4(+) and CD8(+) T cells. | Programmed cell death 2 functions as a tumor suppressor in osteosarcoma.
Yang Y, Jin Y, Du W., Free PMC Article | 10/1/2016 |
| Low PDCD2 expression is associated with gastric cancer. | miR-129-1-3p promote BGC-823 cell proliferation by targeting PDCD2.
Du Y, Wang D, Luo L, Guo J. | 07/25/2015 |
| Loss of PDCD2 expression could contribute to gastric cancer development and progression. | Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.
Zhang J, Wei W, Jin HC, Ying RC, Zhu AK, Zhang FJ. | 07/25/2015 |
| Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. | Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.
Minakhina S, Changela N, Steward R., Free PMC Article | 03/1/2014 |
| PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse. | PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.
Barboza N, Minakhina S, Medina DJ, Balsara B, Greenwood S, Huzzy L, Rabson AB, Steward R, Schaar DG., Free PMC Article | 01/18/2014 |
| PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development. | PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells.
Kokorina NA, Granier CJ, Zakharkin SO, Davis S, Rabson AB, Sabaawy HE., Free PMC Article | 01/26/2013 |
| Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade. | PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade.
Baron BW, Hyjek E, Gladstone B, Thirman MJ, Baron JM. | 12/11/2010 |
| parkin interacts with programmed cell death-2 isoform 1 (PDCD2-1) | Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.
Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set.
Chistiakov DA, Seryogin YA, Turakulov RI, Savost'anov KV, Titovich EV, Zilberman LI, Kuraeva TL, Dedov II, Nosikov VV. | 03/13/2008 |
| To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2. | Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells.
Chen Q, Qian K, Yan C. | 01/21/2010 |
| repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas | Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
Baron BW, Zeleznik-Le N, Baron MJ, Theisler C, Huo D, Krasowski MD, Thirman MJ, Baron RM, Baron JM., Free PMC Article | 01/21/2010 |