| Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach. | Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.
Wong WLE, Arathimos R, Lewis CM, Young AH, Dawe GS., Free PMC Article | 11/28/2023 |
| The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review. | The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.
Wong WLE, Dawe GS, Young AH. | 03/5/2022 |
| Hydrophobic interactions of relaxin family peptide receptor 3 with ligands identified using a NanoBiT-based binding assay. | Hydrophobic interactions of relaxin family peptide receptor 3 with ligands identified using a NanoBiT-based binding assay.
Li HZ, Li N, Shao XX, Liu YL, Xu ZG, Guo ZY. | 05/29/2021 |
| present work shed new light on the interaction mechanism of RXFP3 and RXFP4 with agonists and antagonists, and also provided a novel approach for interaction studies of some plasma membrane receptors with their ligands. | Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay.
Wang JH, Nie WH, Shao XX, Li HZ, Hu MJ, Liu YL, Xu ZG, Guo ZY. | 11/30/2019 |
| This study indicated that RXFP3 mainly localised in the post-acrosomal region of sperm head and neck. | Expression and localisation of RXFP3 in human spermatozoa and impact of INSL7 on sperm functions.
Heidari S, Taromchi AH, Nejatbakhsh R, Shokri S. | 09/22/2018 |
| The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3. | Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.
Hu MJ, Shao XX, Wang JH, Wei D, Guo YQ, Liu YL, Xu ZG, Guo ZY., Free PMC Article | 05/19/2018 |
| Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research. | Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. | 01/27/2018 |
| the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 | A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.
Liu Y, Zhang L, Shao XX, Hu MJ, Liu YL, Xu ZG, Guo ZY. | 05/13/2017 |
| we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor | Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).
Kocan M, Sarwar M, Hossain MA, Wade JD, Summers RJ., Free PMC Article | 01/3/2015 |
| Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3. | The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.
Zhang WJ, Wang XY, Guo YQ, Luo X, Gao XJ, Shao XX, Liu YL, Xu ZG, Guo ZY. | 01/3/2015 |
| demonstrate the existence of an allosteric site for modulation of RXFP3 | In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency.
Alvarez-Jaimes L, Sutton SW, Nepomuceno D, Motley ST, Cik M, Stocking E, Shoblock J, Bonaventure P., Free PMC Article | 08/4/2012 |
| H3 relaxin potently activates all signaling pathways coupled to RXFP3, whereas H2 relaxin is an AP-1-biased ligand relative to H3 relaxin. | H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).
van der Westhuizen ET, Christopoulos A, Sexton PM, Wade JD, Summers RJ. | 05/31/2010 |
| Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors. | Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.
Huang YW, Luo J, Weng YI, Mutch DG, Goodfellow PJ, Miller DS, Huang TH., Free PMC Article | 05/3/2010 |
| Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3. | The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.
Hossain MA, Bathgate RA, Rosengren KJ, Shabanpoor F, Zhang S, Lin F, Tregear GW, Wade JD. | 01/21/2010 |
| the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation. | Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135).
Zhu J, Kuei C, Sutton S, Kamme F, Yu J, Bonaventure P, Atack J, Lovenberg TW, Liu C. | 01/21/2010 |
| analysis of truncated human relaxin-2 and -3 (H2 and H3) relaxin peptides and their binding and cAMP activities on RXFP1, RXFP2, and RXFP3 | The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.
Hossain MA, Rosengren KJ, Haugaard-Jönsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA. | 01/21/2010 |
| Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142. | Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.
Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW. | 01/21/2010 |
| GPCR135 (SALPR) is the receptor for relaxin-3 | Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.
Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, Farmer N, Jörnvall H, Sillard R, Lovenberg TW. | 01/21/2010 |
| functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins | Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.
Van der Westhuizen ET, Sexton PM, Bathgate RA, Summers RJ. | 01/21/2010 |