| Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface. | Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY., Free PMC Article | 08/20/2022 |
| Serum Galanin in Children with Autism Spectrum Disorder. | Serum Galanin in Children with Autism Spectrum Disorder.
Saad K, Abdel-Rahman AA, Al-Atram AA, Abdallah AM, Elhoufey A, Abdelsalam EMN, Nigm DA, Elshora O, Ahmad AR, El-Tellawy MM, Mahmoud KH. | 04/30/2022 |
| Increased Serum Neuropeptide Galanin Level Is a Predictor of Cognitive Dysfunction in Patients with Hip Fracture. | Increased Serum Neuropeptide Galanin Level Is a Predictor of Cognitive Dysfunction in Patients with Hip Fracture.
Xue Z, Zhang K, Luo B, Fan L, Zhao R, Hu G., Free PMC Article | 03/19/2022 |
| Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence. | Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
Randesi M, Levran O, van den Brink W, Blanken P, van Ree JM, Ott J, Kreek MJ., Free PMC Article | 09/25/2021 |
| Review: Occurrence and Distribution of Galanin in the Physiological and Inflammatory States in the Mammalian Gastrointestinal Tract. | Review: Occurrence and Distribution of Galanin in the Physiological and Inflammatory States in the Mammalian Gastrointestinal Tract.
Brzozowska M, Całka J., Free PMC Article | 06/19/2021 |
| Low Galanin expression is associated with gastric cancer. | Galanin expression is down-regulated in patients with gastric cancer.
Zhang L, Fang P, Chai C, Shao L, Mao H, Qiao D, Kong G, Dong X, Shi M, Zhang Z, Bo P., Free PMC Article | 08/1/2020 |
| Study revealed two statistically significant associations between anxiety and the galanin rs948854_C-rs4432027_C haplotype and the rs1042577_T single-locus allele, respectively. | Association between anxiety and non-coding genetic variants of the galanin neuropeptide.
Keszler G, Molnár Z, Rónai Z, Sasvári-Székely M, Székely A, Kótyuk E., Free PMC Article | 03/28/2020 |
| GAL, GAP43 and NRSN1 single nucleotide polymorphisms and related gene-gene interaction networks might be involved in the altered susceptibility to Hirschsprung disease in the Han Chinese population. | Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease.
Wang Y, Yan W, Wang J, Zhou Y, Chen J, Gu B, Cai W., Free PMC Article | 12/14/2019 |
| elevated high expression of CASP3 or CASP8 in the neurons from MPs was accompanied by a decreased expression of GAL. To our knowledge, this is the first report describing the decomposition of myenteric plexuses (MPs) within cancer-affected human stomach wall and the possible role of apoptosis in this process. | Co-expression of caspase-3 or caspase-8 with galanin in the human stomach section affected by carcinoma.
Kozłowska A, Kozera P, Majewski M, Godlewski J., Free PMC Article | 09/28/2019 |
| results suggested that four differentially expressed genes, Jun, Gal, Cd74, and C1qb, had the potential to serve as prognostic or predictive markers for neuropathic pain, suggesting a potential application in the improvement of prognostic tools and treatments. | Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.
Yang JA, He JM, Lu JM, Jie LJ. | 03/2/2019 |
| Notable changes in the dense network of cocaine- and amphetamine-regulated transcript- (CART-) and galanin -containing nerve fibers (an increase) were observed in the longitudinal (LML) and lamina muscularis mucosae (LMM) within carcinoma-affected areas of the human stomach. | Distribution Patterns of Cocaine- and Amphetamine-Regulated Transcript- and/or Galanin-Containing Neurons and Nerve Fibers Located in the Human Stomach Wall Affected by Tumor.
Kozłowska A, Godlewski J, Majewski M., Free PMC Article | 02/9/2019 |
| SNP rs948854 in the GAL gene seems to be involved in the modulation of depressive state, especially in individuals with GG genotype. | Implication of galanin gene rs948854 polymorphism in depressive symptoms in adolescents.
da Conceição Machado F, de Souza LV, Rangel M, Jara ZP, do Carmo Franco M. | 12/22/2018 |
| Higher serum galanin levels were determined in patients with impaired glucose tolerance. | Serum Galanin Concentration is Increased in Subjects with Impaired Glucose Tolerance.
Zhang Z, Fang P, Yu M, Wang Y, Li Y, Shi M, Bo P, Gu X, Zhu Y. | 07/21/2018 |
| Serum galanin (GAL) levels are significantly higher in the obese group compared with lean subjects during an oral glucose tolerance test (OGTT). | Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.
Sandoval-Alzate HF, Agudelo-Zapata Y, González-Clavijo AM, Poveda NE, Espinel-Pachón CF, Escamilla-Castro JA, Márquez-Julio HL, Alvarado-Quintero H, Rojas-Rodríguez FG, Arteaga-Díaz JM, Eslava-Schmalbach JH, Garcés-Gutiérrez MF, Vrontakis M, Castaño JP, Luque RM, Diéguez C, Nogueiras R, Caminos JE., Free PMC Article | 05/12/2018 |
| Galanin per se did not affect the dynamic mass redistribution of natural killer (NK) cells, but significantly enhanced the response of NK cells to IL-18 | The neuropeptide galanin modulates natural killer cell function.
Koller A, Bianchini R, Schlager S, Münz C, Kofler B, Wiesmayr S. | 05/5/2018 |
| majority of intrinsic choroidal neurons were GAL-positive | Distribution of the neuro-regulatory peptide galanin in the human eye.
Kaser-Eichberger A, Trost A, Strohmaier C, Bogner B, Runge C, Bruckner D, Hohberger B, Jünemann A, Kofler B, Reitsamer HA, Schrödl F. | 05/5/2018 |
| ultraviolet irradiation upregulated galanin mRNA and protein expression in keratinocytes in vitro and in human skin in vivo | Galanin contributes to ultraviolet irradiation-induced inflammation in human skin.
Lee MJ, Oh JH, Park CH, Kim KH, Lee DH, Chung JH. | 04/28/2018 |
| GAL and its receptor GALR3 are differentially methylated and expressed in brains of major depressive disorder subjects in a region- and sex-specific manner. | Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide.
Barde S, Rüegg J, Prud'homme J, Ekström TJ, Palkovits M, Turecki G, Bagdy G, Ihnatko R, Theodorsson E, Juhasz G, Diaz-Heijtz R, Mechawar N, Hökfelt TG., Free PMC Article | 04/14/2018 |
| Study found dramatic reduction in von Willebrand factor extrusion and multimer expression by the neuropeptide galanin in cultured endocardial endothelial cells from heart failure patients. Results suggest that a combination of beta-blockers and galanin therapy may be one therapeutic option for improving endocardial endothelial anticoagulant function. | The neuropeptide galanin promotes an anti-thrombotic phenotype on endocardial endothelial cells from heart failure patients.
Tyrrell C, Toyooka A, Khan F, Thornburg KL, Mudd JO, Hasan W. | 12/9/2017 |
| The analyses revealed that the presence of the galanin gene minor allele (G) increased susceptibility to multiple sclerosis in men (OR = 2.49, P = 0.008) but not in women. | Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor.
Lioudyno V, Abdurasulova I, Bisaga G, Skulyabin D, Klimenko V. | 11/18/2017 |
| Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. | Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.
Misawa K, Mochizuki D, Endo S, Mima M, Misawa Y, Imai A, Shinmura K, Kanazawa T, Carey TE, Mineta H. | 09/9/2017 |
| Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals | Identification and Evaluation of New Immunoregulatory Genes in Mesenchymal Stromal Cells of Different Origins: Comparison of Normal and Inflammatory Conditions.
Fayyad-Kazan M, Najar M, Fayyad-Kazan H, Raicevic G, Lagneaux L., Free PMC Article | 06/3/2017 |
| Low levels of plasma galanin is associated with obese subjects with hypertension. | Low levels of plasma galanin in obese subjects with hypertension.
Fang P, Yu M, Gu X, Shi M, Zhu Y, Zhang Z, Bo P. | 04/29/2017 |
| results indicated that obese individuals have higher plasma GAL and GALP concentrations and both peptide concentrations were positively correlative to triglyceride concentrations in obese human | Circulating galanin and galanin like peptide concentrations are correlated with increased triglyceride concentration in obese patients.
Fang P, Yu M, Gu X, Shi M, Zhu Y, Zhang Z, Bo P. | 02/18/2017 |
| GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis | Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.
Misawa K, Misawa Y, Kanazawa T, Mochizuki D, Imai A, Endo S, Carey TE, Mineta H. | 07/30/2016 |