| NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. | NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells.
Choi HY, Zhu Y, Zhao X, Mehta S, Hernandez JC, Lee JJ, Kou Y, Machida R, Giacca M, Del Sal G, Ray R, Eoh H, Tahara SM, Chen L, Tsukamoto H, Machida K., Free PMC Article | 03/7/2024 |
| A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission. | A conserved, noncanonical insert in FIS1 mediates TBC1D15 and DRP1 recruitment for mitochondrial fission.
Ihenacho UK, Toro R, Mansour RH, Hill RB., Free PMC Article | 11/30/2023 |
| Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. | Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension.
Zhou X, Jiang Y, Wang Y, Fan L, Zhu Y, Chen Y, Wang Y, Zhu Y, Wang H, Pan Z, Li Z, Zhu X, Ren R, Ge Z, Lai D, Lai EY, Chen T, Wang K, Liang P, Qin L, Liu C, Qiu C, Simons M, Yu L. | 09/20/2023 |
| PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation. | PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation.
An S, Yao Y, Hu H, Wu J, Li J, Li L, Wu J, Sun M, Deng Z, Zhang Y, Gong S, Huang Q, Chen Z, Zeng Z., Free PMC Article | 07/25/2023 |
| Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission. | Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission.
Egner JM, Nolden KA, Harwig MC, Bonate RP, De Anda J, Tessmer MH, Noey EL, Ihenacho UK, Liu Z, Peterson FC, Wong GCL, Widlansky ME, Hill RB., Free PMC Article | 01/11/2023 |
| Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics. | Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics.
Wong YC, Kim S, Cisneros J, Molakal CG, Song P, Lubbe SJ, Krainc D., Free PMC Article | 09/10/2022 |
| Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1. | Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1.
Wilkinson KA, Guo C., Free PMC Article | 07/23/2022 |
| PEX11beta and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor. | PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.
Schrader TA, Carmichael RE, Islinger M, Costello JL, Hacker C, Bonekamp NA, Weishaupt JH, Andersen PM, Schrader M., Free PMC Article | 07/16/2022 |
| FIS1 Overexpression Is Correlated with Tumor Metastasis in Gastric Adenocarcinoma. | FIS1 Overexpression Is Correlated with Tumor Metastasis in Gastric Adenocarcinoma.
Karimi D, Pedram N, Kakaei F, Asadi M, Poursaei E, Kermani TA. | 06/18/2022 |
| DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury. | DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury.
Wang S, Zhu H, Li R, Mui D, Toan S, Chang X, Zhou H. | 04/9/2022 |
| Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis. | Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis.
Yu Y, Peng XD, Qian XJ, Zhang KM, Huang X, Chen YH, Li YT, Feng GK, Zhang HL, Xu XL, Li S, Li X, Mai J, Li ZL, Huang Y, Yang D, Zhou LH, Zhong ZY, Li JD, Deng R, Zhu XF., Free PMC Article | 03/26/2022 |
| Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease. | Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease.
Ihenacho UK, Meacham KA, Harwig MC, Widlansky ME, Hill RB., Free PMC Article | 01/22/2022 |
| Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity. | Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity.
Houzelle A, Jörgensen JA, Schaart G, Daemen S, van Polanen N, Fealy CE, Hesselink MKC, Schrauwen P, Hoeks J., Free PMC Article | 01/22/2022 |
| Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72. | Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.
Chai N, Haney MS, Couthouis J, Morgens DW, Benjamin A, Wu K, Ousey J, Fang S, Finer S, Bassik MC, Gitler AD., Free PMC Article | 04/24/2021 |
| In human EPCs, down-regulation of Fis1 is involved in mitochondrial dysfunction and contributes to the impaired activity of EPCs during the senescence process. Enhanced expression of Fis1 in senescent EPCs restores the youthful phenotype. | Mitochondrial fission protein 1 up-regulation ameliorates senescence-related endothelial dysfunction of human endothelial progenitor cells.
Wang HH, Wu YJ, Tseng YM, Su CH, Hsieh CL, Yeh HI. | 07/4/2020 |
| FIS1 and PDCD7 expression are considered independent risk factors and should be integrated into the current acute myeloid leukemia stratification system | The clinical and prognostic significance of FIS1, SPI1, PDCD7 and Ang2 expression levels in acute myeloid leukemia.
Abo Elwafa R, Gamaleldin M, Ghallab O. | 02/15/2020 |
| data suggest a model in which leukemia stem cells co-opt AMPK/FIS1-mediated mitophagy as a means to maintain stem cell properties that may be otherwise compromised by the stresses induced by oncogenic transformation | AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT., Free PMC Article | 10/5/2019 |
| Study demonstrated that the STX17 initiates mitophagy upon depletion of outer mitochondrial membrane protein Fis1. Fis1 loss results in aberrant STX17 accumulation on mitochondria, which exposes the N terminus and promotes self-oligomerization to trigger mitophagy. Findings uncover a PINK1/Parkin-independent mitophagic mechanism in which outer mitochondrial membrane protein Fis1 regulates mitochondrial quality control. | STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.
Xian H, Yang Q, Xiao L, Shen HM, Liou YC., Free PMC Article | 06/8/2019 |
| Glomerular overproduction of Drp1, phospho-Drp1 (Ser 616) and Fis1 occurred mainly in children with membranous nephropathy. | Overproduction of Mitochondrial Fission Proteins in Membranous Nephropathy in Children.
Wei QJ, Xu H, Guan N, Ren YL, Liu XY, Wu GH, Zhu SN. | 03/2/2019 |
| we found that differential expression of BAK1, FIS1, and SFN were altered across the Barrett's disease sequence and manipulation of these genes elicited significant effects on mitochondrial membrane potential. | The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus.
Phelan JJ, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J., Free PMC Article | 02/16/2019 |
| inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions. | Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.
Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D., Free PMC Article | 02/9/2019 |
| Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function. | Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function.
Kim D, Song J, Kang Y, Park S, Kim YI, Kwak S, Lim D, Park R, Chun CH, Choe SK, Jin EJ. | 01/6/2018 |
| Results show that Fis1 is significantly overexpressed in malignant oncocytomas. | Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration.
Ferreira-da-Silva A, Valacca C, Rios E, Pópulo H, Soares P, Sobrinho-Simões M, Scorrano L, Máximo V, Campello S., Free PMC Article | 03/19/2016 |
| Study revealed that a novel mitochondrial fission pathway composed of miR-483-5p and FIS1 regulates cisplatin sensitivity. | miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1.
Fan S, Chen WX, Lv XB, Tang QL, Sun LJ, Liu BD, Zhong JL, Lin ZY, Wang YY, Li QX, Yu X, Zhang HQ, Li YL, Wen B, Zhang Z, Chen WL, Li JS. | 06/27/2015 |
| PDCD7, Ang2 and FIS1 may indicate a more aggressive form and poor prognosis of acute myeloid leukemia. | Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia.
Tian Y, Huang Z, Wang Z, Yin C, Zhou L, Zhang L, Huang K, Zhou H, Jiang X, Li J, Liao L, Yang M, Meng F., Free PMC Article | 09/13/2014 |