| Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression. | Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ., Free PMC Article | 09/26/2023 |
| The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis. | The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
Lee SY, Park SY, Lee SH, Kim H, Kwon JH, Yoo JY, Kim K, Park MS, Lee CG, Elias JA, Sohn MH, Shim HS, Yoon HG., Free PMC Article | 09/8/2023 |
| Data suggest that the activity of oocyte UCHL-1 and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle. | Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation.
Mtango NR, Sutovsky M, Vandevoort CA, Latham KE, Sutovsky P., Free PMC Article | 04/7/2012 |
| subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 in the oocyte cortex | Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
Mtango NR, Sutovsky M, Susor A, Zhong Z, Latham KE, Sutovsky P., Free PMC Article | 03/10/2012 |
| impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie | Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW. | 10/15/2011 |
| Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 signaling | Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation.
Kim JY, Lee JM, Cho JY. | 08/6/2011 |
| Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice. | Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.
Setsuie R, Suzuki M, Tsuchiya Y, Wada K. | 12/4/2010 |
| Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin signaling in a hydrolase activity-dependent manner. | Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis.
Suzuki M, Setsuie R, Wada K. | 01/25/2010 |
| The role of ubiquitin C-terminal hydrolase (UCH)-L3 in the regulation of AMP-activated protein kinase activity and whole-body energy metabolism are reportedl | Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.
Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K. | 01/25/2010 |
| Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice. | The hippocampal proteomic analysis of senescence-accelerated mouse: implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8.
Wang Q, Liu Y, Zou X, Wang Q, An M, Guan X, He J, Tong Y, Ji J. | 01/21/2010 |
| UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel | The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel.
Butterworth MB, Edinger RS, Ovaa H, Burg D, Johnson JP, Frizzell RA. | 01/21/2010 |