| LIGHT/TNFSF14 Affects Adipose Tissue Phenotype. | LIGHT/TNFSF14 Affects Adipose Tissue Phenotype.
Oranger A, Colaianni G, Ingravallo G, Scarcella VS, Faienza MF, Grano M, Colucci S, Brunetti G., Free PMC Article | 01/31/2024 |
| LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment. | LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment.
Zhang N, Liu X, Qin J, Sun Y, Xiong H, Lin B, Liu K, Tan B, Zhang C, Huang C, Ren S, Liu M, Du B., Free PMC Article | 11/2/2023 |
| Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts Neovascularization by Decreasing Circulating Endothelial Progenitor Cells and Function. | Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts Neovascularization by Decreasing Circulating Endothelial Progenitor Cells and Function.
Hsu CY, Huang CY, Shih CM, Lin YW, Huang PH, Lin SJ, Liu CW, Lin CY, Lin FY., Free PMC Article | 05/5/2023 |
| LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis. | LIGHT Amplification by NF-κB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis.
Lai D, Lv Z, Lu X, Shang P, Geng Y, Wang P., Free PMC Article | 01/28/2023 |
| LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia. | LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia.
Shi LN, Zhou Y, Wu C, Huang W, Yuan F, Chen J, Wu Z, Tu W, Chen H, Chen Q, Zhu M, Peng H, Yang Y, Tang H. | 01/28/2023 |
| The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts. | The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts.
Ikawa T, Ichimura Y, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y. | 06/11/2022 |
| LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients. | LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients.
Brunetti G, Belisario DC, Bortolotti S, Storlino G, Colaianni G, Faienza MF, Sanesi L, Alliod V, Buffoni L, Centini E, Voena C, Pulito R, Novello S, Ingravallo G, Rizzi R, Mori G, Reseland JE, Ware CF, Colucci S, Ferracini R, Grano M, Roato I. | 09/18/2021 |
| LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis. | LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis.
Yang Y, Meng L, Wu S, Li Y, Zhong Y, Xu F, Zhou XC, Li GQ, Xu GL, Peng KF. | 05/29/2021 |
| LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-kappaB pathway. | LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-κB pathway.
Zhong Y, Wu S, Yang Y, Li GQ, Meng L, Zheng QY, Li Y, Xu GL, Zhang KQ, Peng KF., Free PMC Article | 05/8/2021 |
| LIGHT/LTbetaR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells. | LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Höpner SS, Raykova A, Radpour R, Amrein MA, Koller D, Baerlocher GM, Riether C, Ochsenbein AF., Free PMC Article | 02/27/2021 |
| Increased LIGHT expression and activation of non-canonical NF-kappaB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. | Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection.
Mejías-Luque R, Lozano-Pope I, Wanisch A, Heikenwälder M, Gerhard M, Obonyo M., Free PMC Article | 11/21/2020 |
| Light protein deficiency in a high-fat high-cholesterol diet improves hepatic glucose tolerance, and reduces hepatic inflammation and non-alcoholic fatty liver disease; this is accompanied by decreased systemic inflammation and adipose tissue cytokine secretion and by changes in the expression of key genes such as Klf6 and Tlr4 involved in NAFLD | Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis.
Herrero-Cervera A, Vinué Á, Burks DJ, González-Navarro H. | 07/11/2020 |
| LIGHT stimulation increases OPG levels in B, CD8(+) T, and osteoblastic cells, as well as Wnt10b expression in CD8(+) T cells. The high bone mass in Light and T- and B-cell-deficient mice (Rag(-) /Tnfsf14(-) ) supports the cooperative role of the immune system in bone homeostasis. | Impairment of Bone Remodeling in LIGHT/TNFSF14-Deficient Mice.
Brunetti G, Faienza MF, Colaianni G, Gigante I, Oranger A, Pignataro P, Ingravallo G, Di Benedetto A, Bortolotti S, Di Comite M, Storlino G, Lippo L, Ward-Kavanagh L, Mori G, Reseland JE, Passeri G, Schipani E, Tamada K, Ware CF, Colucci S, Grano M. | 10/26/2019 |
| LIGHT signaling through lymphotoxin beta receptor plays a critical role in the progression of experimental colitis | The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation.
Giles DA, Zahner S, Krause P, Van Der Gracht E, Riffelmacher T, Morris V, Tumanov A, Kronenberg M., Free PMC Article | 10/12/2019 |
| findings identify the LIGHT axis as a regulator of adipose tissue homeostasis and suggest that LIGHT signaling functions as a mechanism to divert energy in favor of immune activation | LIGHT/TNFSF14 signaling attenuates beige fat biogenesis.
Kou Y, Liu Q, Liu W, Sun H, Liang M, Kong F, Zhang B, Wei Y, Liu Z, Wang Y. | 10/5/2019 |
| Mice with a conditional deletion of the LIGHT receptor HVEM (herpesvirus entry mediator) in keratinocytes phenocopied LIGHT-deficient mice in exhibiting reduced epidermal thickening and dermal collagen deposition in a model of atopic dermatitis driven by house dust mite allergen. | LIGHT-HVEM signaling in keratinocytes controls development of dermatitis.
Herro R, Shui JW, Zahner S, Sidler D, Kawakami Y, Kawakami T, Tamada K, Kronenberg M, Croft M., Free PMC Article | 04/13/2019 |
| These results underscore the importance of LIGHT activity in programming memory CD8 T cell development, and suggest that CD8 effector T cells can dictate their own fate into becoming memory cells by expressing LIGHT. | The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.
Desai P, Tahiliani V, Hutchinson TE, Dastmalchi F, Stanfield J, Abboud G, Thomas PG, Ware CF, Song J, Croft M, Salek-Ardakani S., Free PMC Article | 04/6/2019 |
| bone marrow cells from Tnfsf14 deficient mice appeared to promote diet-induced obesity, insulin resistance and reduced FGF21 levels in white adipose tissue and liver | Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production.
Saunders BM, Rudnicka C, Filipovska A, Davies S, Ward N, Hricova J, Schlaich MP, Matthews VB. | 12/22/2018 |
| Blockade of LIGHT markedly suppressed airway smooth muscle hyperplasia and inflammatory responses, which might be modulated through HVEM-NFkappaB or c-JUN pathways. | The Role of TNF Family Molecules Light in Cellular Interaction Between Airway Smooth Muscle Cells and T Cells During Chronic Allergic Inflammation.
Shi F, Xiong Y, Zhang Y, Qiu C, Li M, Shan A, Yang Y, Li B. | 10/13/2018 |
| The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas. | Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin β-Receptor pathway.
Andrés-Blasco I, Vinué Á, Herrero-Cervera A, Martínez-Hervás S, Nuñez L, Piqueras L, Ascaso JF, Sanz MJ, Burks DJ, González-Navarro H. | 01/20/2018 |
| LIGHT promote myeloid differentiation of Hematopoietic stem/progenitor cells via LIGHT receptor signaling. | Hematopoietic stem/progenitor cell differentiation towards myeloid lineage is modulated by LIGHT/LIGHT receptor signaling.
Chen W, Lv X, Liu C, Chen R, Liu J, Dai H, Zou GM. | 11/25/2017 |
| LIGHT signalling pathway combined with IFN-gamma induces beta cells apoptosis via an NF-kappaB/Bcl2-dependent mitochondrial pathway. | LIGHT/IFN-γ triggers β cells apoptosis via NF-κB/Bcl2-dependent mitochondrial pathway.
Zheng QY, Cao ZH, Hu XB, Li GQ, Dong SF, Xu GL, Zhang KQ., Free PMC Article | 07/15/2017 |
| Increasing LIGHT expression increased T-cell proliferation, activation, and infiltration, resulting in enhanced tumor-specific immune-mediated tumor regressions in primary tumors and colorectal liver metastases. | LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.
Qiao G, Qin J, Kunda N, Calata JF, Mahmud DL, Gann P, Fu YX, Rosenberg SA, Prabhakar BS, Maker AV., Free PMC Article | 05/13/2017 |
| Together, these results demonstrate that the LIGHT signaling pathway is not only required for inflammatory cytokine production as part of the host response to chlamydial infection, but also influences the differentiation of CD4(+) CD25(+) FoxP3(+) Treg cells, both of which may be essential for control of C. psittaci respiratory tract infection. | Deficiency of LIGHT signaling pathway exacerbates Chlamydia psittaci respiratory tract infection in mice.
Cai H, Chen S, Xu S, Sun Y, Bai Q, Lu C, Chen Y, Fu X, Xu G, Chen L. | 04/8/2017 |
| These results expose the relevance of LIGHT/LTbetaR/HVEM interaction for the potential therapeutic control of the allogeneic immune responses mediated by alloreactive CD8 T cells that can contribute to prolong allograft survival. | Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells.
del Rio ML, Fernandez-Renedo C, Chaloin O, Scheu S, Pfeffer K, Shintani Y, Perez-Simon JA, Schneider P, Rodriguez-Barbosa JI., Free PMC Article | 12/17/2016 |