| DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent manner. | DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/β-catenin pathway-dependent manner.
Song J, Chen Y, Chen Y, Qiu M, Xiang W, Ke B, Fang X., Free PMC Article | 05/23/2024 |
| Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model. | Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
Martin Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, Leonenko G, Escott-Price V, Salinas PC., Free PMC Article | 02/1/2024 |
| A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis. | A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
Cooney RA, Saal ML, Geraci KP, Maynard C, Cleaver O, Hoang ON, Moore TT, Hwang RF, Axelrod JD, Vladar EK., Free PMC Article | 09/1/2023 |
| Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats. | Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
Busceti CL, Carrizzo A, Bianchi F, De Lucia M, Damato A, Cazzin C, Venturini E, Di Pietro P, Ginerete RP, Di Menna L, Cotugno M, Stanzione R, Marchitti S, Migliarino S, Ciccarelli M, Sciarretta S, Bruno V, Battaglia G, Fornai F, Volpe M, Rubattu S, Nicoletti F, Vecchione C. | 06/2/2023 |
| Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis. | Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
Zeng N, Wen YH, Pan R, Yang J, Yan YM, Zhao AZ, Zhu JN, Fang XH, Shan ZX. | 02/12/2022 |
| Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration. | Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
Arnold F, Mahaddalkar PU, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel AK, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz SF, Lechel A, Rad R, Seufferlein T, Kestler HA, Ott M, Sharma AD, Hermann PC, Kleger A., Free PMC Article | 01/8/2022 |
| Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse. | Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
Song KM, Kim WJ, Choi MJ, Limanjaya A, Ghatak K, Minh NN, Ock J, Yin GN, Hong SS, Suh JK, Ryu JK. | 08/14/2021 |
| Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland. | Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
Fujita H, Bando T, Oyadomari S, Ochiai K, Watanabe M, Kumon H, Ohuchi H. | 04/3/2021 |
| DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage. | DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
Xu Y, Nowrangi D, Liang H, Wang T, Yu L, Lu T, Lu Z, Zhang JH, Luo B, Tang J., Free PMC Article | 03/20/2021 |
| Dkk3 maintains the integrity of secreting vesicles in mouse adrenal medulla by regulating the expression of chromogranin A and neuropeptide Y | Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla.
Habuta M, Fujita H, Sato K, Bando T, Inoue J, Kondo Y, Miyaishi S, Kumon H, Ohuchi H. | 05/23/2020 |
| Dkk3 binds to CXCR7 and enhances vascular progenitor cells cell migration and vascular regeneration. | Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration.
Issa Bhaloo S, Wu Y, Le Bras A, Yu B, Gu W, Xie Y, Deng J, Wang Z, Zhang Z, Kong D, Hu Y, Qu A, Zhao Q, Xu Q., Free PMC Article | 10/5/2019 |
| DKK3 overexpression substantially alleviated AngII infusion-induced cardiac hypertrophy and fibrosis by regulating ADAM17/ACE2 pathway activity and inhibiting the GSK-3beta/beta-catenin pathway. | DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways.
Zhai CG, Xu YY, Tie YY, Zhang Y, Chen WQ, Ji XP, Mao Y, Qiao L, Cheng J, Xu QB, Zhang C. | 06/29/2019 |
| DKK3 altered the atherosclerotic plaque content by increasing smooth muscle cell differentiation/numbers and reducing vascular inflammation. | DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.
Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML, Zhang Z, Wang X, Del Barco Barrantes I, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C, Xu Q. | 01/19/2019 |
| findings suggest that Dkk3 may be used as diagnostic marker and as therapeutic target for age-related muscle atrophy, and reveal a distinct transcriptional control of Fbxo32 and Trim63 | Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy.
Yin J, Yang L, Xie Y, Liu Y, Li S, Yang W, Xu B, Ji H, Ding L, Wang K, Li G, Chen L, Hu P., Free PMC Article | 12/22/2018 |
| The data of this study suggest that Dkk3 is an agonist of Wnt signaling, and the ability of transgenic expression of Dkk3 to compensate for the decrease in Dkk3 expression in AD mice, reverse dysfunctional Wnt signaling, and partially inhibit the pathological development of AD suggests that Dkk3 could serve as a therapeutic target for the treatment of AD. | Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer's Disease.
Zhang L, Sun C, Jin Y, Gao K, Shi X, Qiu W, Ma C, Zhang L. | 04/14/2018 |
| DKK3 expression in macrophages is involved in the pathogenesis of atherosclerosis through modulation of inflammation and inactivation of the Wnt/beta-catenin pathway. | Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice.
Cheng WL, Yang Y, Zhang XJ, Guo J, Gong J, Gong FH, She ZG, Huang Z, Xia H, Li H., Free PMC Article | 03/3/2018 |
| DKK3 deficiency accelerated atherosclerosis and delayed re-endothelialization and exacerbated neointima formation. | A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective.
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Barco Barrantes ID, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A, Xu Q., Free PMC Article | 10/7/2017 |
| These results suggest that Dkk3 has pleiotropic roles for a secretory glycoprotein that acts primarily in the gastrointestinal tract, thymus, endocrine and reproductive organs of the mouse. | Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse.
Inoue J, Fujita H, Bando T, Kondo Y, Kumon H, Ohuchi H. | 03/11/2017 |
| these data suggest that downregulation of tubular beta-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis. | Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy.
Wong DW, Yiu WH, Wu HJ, Li RX, Liu Y, Chan KW, Leung JC, Chan LY, Lai KN, Tang SC., Free PMC Article | 11/19/2016 |
| Dkk3 expression was seen in the superficial zone of the mandibular condyle cartilage. | Cell and matrix response of temporomandibular cartilage to mechanical loading.
Utreja A, Dyment NA, Yadav S, Villa MM, Li Y, Jiang X, Nanda R, Rowe DW., Free PMC Article | 10/22/2016 |
| Studied role of Dkk3 on the pathogenesis of familial dilated cardiomyopathy, and whether and how Dkk3 interferes with Wnt signaling in heart tissues. | Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway.
Lu D, Bao D, Dong W, Liu N, Zhang X, Gao S, Ge W, Gao X, Zhang L. | 05/28/2016 |
| the soluble DKK3 protein might be a promising new agent for the improvement of current protocols for the directed differentiation of pluripotent and multipotent stem cells | Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.
Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W, Prakash N., Free PMC Article | 01/2/2016 |
| DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin expression. | Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling.
Wang X, Karamariti E, Simpson R, Wang W, Xu Q., Free PMC Article | 11/7/2015 |
| Date indicate that B1 cells have a better survival and proliferation capacity in the absence of Dickkopf-3 protein (DKK3). | Dickkopf-3 acts as a modulator of B cell fate and function.
Ludwig J, Federico G, Prokosch S, Küblbeck G, Schmitt S, Klevenz A, Gröne HJ, Nitschke L, Arnold B. | 06/20/2015 |
| DKK3 acts as a cardioprotective regulator of pathological cardiac hypertrophy | Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.
Zhang Y, Liu Y, Zhu XH, Zhang XD, Jiang DS, Bian ZY, Zhang XF, Chen K, Wei X, Gao L, Zhu LH, Yang Q, Fan GC, Lau WB, Ma X, Li H., Free PMC Article | 11/29/2014 |