| USP7 controls NGN3 stability and pancreatic endocrine lineage development. | USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Manea T, Nelson JK, Garrone CM, Hansson K, Evans I, Behrens A, Sancho R., Free PMC Article | 05/3/2023 |
| Novel Variants and Phenotypes in NEUROG3-Associated Syndrome. | Novel Variants and Phenotypes in NEUROG3-Associated Syndrome.
Wejaphikul K, Srilanchakon K, Kamolvisit W, Jantasuwan S, Santawong K, Tongkobpetch S, Theerapanon T, Damrongmanee A, Hongsawong N, Ukarapol N, Dejkhamron P, Supornsilchai V, Porntaveetus T, Shotelersuk V. | 12/31/2022 |
| Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network. | Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network.
Schreiber V, Mercier R, Jiménez S, Ye T, García-Sánchez E, Klein A, Meunier A, Ghimire S, Birck C, Jost B, de Lichtenberg KH, Honoré C, Serup P, Gradwohl G., Free PMC Article | 03/26/2022 |
| Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas. | Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas.
Yong HJ, Xie G, Liu C, Wang W, Naji A, Irianto J, Wang YJ., Free PMC Article | 02/19/2022 |
| Recognition of maturity-onset diabetes of the young in China. | Recognition of maturity-onset diabetes of the young in China.
Liang H, Zhang Y, Li M, Yan J, Yang D, Luo S, Zheng X, Yang G, Li Z, Xu W, Groop L, Weng J., Free PMC Article | 02/5/2022 |
| Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder. | Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder.
Hou Z, Liu X, Jiang W, Hou Z, Yin Y, Xie C, Zhang H, Zhang H, Zhang Z, Yuan Y. | 01/29/2022 |
| Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E. coli. | Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E. coli.
Narayan G, Agrawal A, Joshi N, Gogoi R, Nagotu S, Thummer RP. | 01/15/2022 |
| Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus. | Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus.
Solorzano-Vargas RS, Bjerknes M, Wang J, Wu SV, Garcia-Careaga MG, Pitukcheewanont P, Cheng H, German MS, Georgia S, Martín MG., Free PMC Article | 05/15/2021 |
| Reversible expansion of pancreatic islet progenitors derived from human induced pluripotent stem cells. | Reversible expansion of pancreatic islet progenitors derived from human induced pluripotent stem cells.
Tanaka A, Watanabe A, Nakano Y, Matsumoto M, Okazaki Y, Miyajima A. | 12/12/2020 |
| PTEN and BMI1 help mediate NEUROGENIN-3-induced cell cycle arrest | The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3-induced cell cycle arrest.
Solorzano-Vargas RS, Bjerknes M, Wu SV, Wang J, Stelzner M, Dunn JCY, Dhawan S, Cheng H, Georgia S, Martín MG., Free PMC Article | 06/13/2020 |
| human organoid cells derived from the pancreatic tissue can be reprogrammed into the insulin-producing cells (IPCs) by the combination of in vitro transcribed modified mRNA encoding transcription factor neurogenin 3 and small molecules modulating the epigenetic state and signalling pathways. | Reprogramming of Human Pancreatic Organoid Cells into Insulin-Producing β-Like Cells by Small Molecules and in Vitro Transcribed Modified mRNA Encoding Neurogenin 3 Transcription Factor.
Koblas T, Leontovyc I, Loukotová S, Saudek F. | 03/14/2020 |
| NEUROG3 pathogenic mutations affect protein stability, dimerization, and DNA binding. | A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development.
Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM., Free PMC Article | 03/7/2020 |
| novel homozygous nonsense mutation (p.Q4*) as the genetic cause of neonatal diabetes mellitus and severe malabsorptive diarrhea in 2 cousins | A novel NEUROG3 mutation in neonatal diabetes associated with a neuro-intestinal syndrome.
Hancili S, Bonnefond A, Philippe J, Vaillant E, De Graeve F, Sand O, Busiah K, Robert JJ, Polak M, Froguel P, Güven A, Vaxillaire M. | 10/20/2018 |
| PDX1, Neurogenin-3, and MAFA are critical transcription regulators for beta cell development and regeneration. (Review) | PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration.
Zhu Y, Liu Q, Zhou Z, Ikeda Y., Free PMC Article | 06/9/2018 |
| Sox9 and Ngn3, key transcription factors associated with pancreatic development. | Adult human pancreas-derived cells expressing stage-specific embryonic antigen 4 differentiate into Sox9-expressing and Ngn3-expressing pancreatic ducts in vivo.
Lee S, Lee CM, Kim SC., Free PMC Article | 11/11/2017 |
| This reviews the expression and function of NEUROG3 in both mouse and human pancreatic development. [Review Article] | Revisiting the immunocytochemical detection of Neurogenin 3 expression in mouse and man.
Honoré C, Rescan C, Hald J, McGrath PS, Petersen MB, Hansson M, Klein T, Østergaard S, Wells JM, Madsen OD. | 11/4/2017 |
| Neurogenin3 controls its ability to promote pancreatic endocrine differentiation and to maintain beta cell function in the presence of pro-proliferation cues | Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.
Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A., Free PMC Article | 09/23/2017 |
| Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors | Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.
Krentz NAJ, van Hoof D, Li Z, Watanabe A, Tang M, Nian C, German MS, Lynn FC., Free PMC Article | 09/16/2017 |
| Collectively, our results demonstrate that the STAT3(K392R) mutation causes premature endocrine differentiation through direct induction of NEUROG3 expression. | An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, Grym H, Ustinov J, Wartiovaara K, Hawkins RD, Silvennoinen O, Varjosalo M, Morgan NG, Otonkoski T. | 05/6/2017 |
| inflammatory cytokine insults stimulate epithelial-to-mesenchymal transition (EMT) as well as the endocrine program in human pancreatic ductal cells via STAT3-dependent NGN3 activation. | Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation.
Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AKK, Kulkarni RN., Free PMC Article | 01/14/2017 |
| ChIP experiments confirmed that Pdx1 activates the expression of the downstream transcription factors, Ngn3 and Pax6, by combined with the promoter regions of insulin (Insulin-P), Ngn3 (Ngn3-P), and Pax6 (Pax6-P). | Pdxl and its role in activating Ngn3 and Pax6 to induce differentiation of iPSCs into islet β cells.
Qin Y, Xiao L, Zhan XB, Zhou HX. | 06/28/2016 |
| NGN3 expression in the adult human exocrine pancreas marks a dedifferentiating cell population. | Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.
Gomez DL, O'Driscoll M, Sheets TP, Hruban RH, Oberholzer J, McGarrigle JJ, Shamblott MJ., Free PMC Article | 05/14/2016 |
| conclude that NEUROG3 is essential for endocrine pancreas development in humans and that as little as 10% NEUROG3 is sufficient for formation of pancreatic endocrine cells | The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.
McGrath PS, Watson CL, Ingram C, Helmrath MA, Wells JM., Free PMC Article | 09/26/2015 |
| NEUROG3 deficiency produces a rare clinical syndrome characterised by severe malabsorptive diarrhoea from early life and mild diabetes with a variable age of onset. | Neurogenin 3 is important but not essential for pancreatic islet development in humans.
Rubio-Cabezas O, Codner E, Flanagan SE, Gómez JL, Ellard S, Hattersley AT., Free PMC Article | 07/25/2015 |
| Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury. | Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
Marzioni M, Agostinelli L, Candelaresi C, Saccomanno S, De Minicis S, Maroni L, Mingarelli E, Rychlicki C, Trozzi L, Banales JM, Benedetti A, Baroni GS. | 05/16/2015 |