| lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis. | lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis.
Li G, Chen Q., Free PMC Article | 11/6/2023 |
| Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men. | Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men.
Opoku Mensah B, Fondjo LA, Owiredu WKBA, Adusei B., Free PMC Article | 10/29/2022 |
| PCA3 controls chromatin organization and p53 signal activation by regulating LAP2alpha-lamin A complexes. | PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes.
Ito S, Ueda T, Yokoyama A, Fujihara A, Hongo F, Ukimura O. | 05/14/2022 |
| Circulating RNAs in prostate cancer patients. | Circulating RNAs in prostate cancer patients.
Mugoni V, Ciani Y, Nardella C, Demichelis F. | 01/8/2022 |
| LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling. | LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
Guo S, Zhang Y, Wang S, Yang T, Ma B, Li X, Zhang Y, Jiang X. | 07/10/2021 |
| Promoter polymorphisms of the PCA3 gene are not associated with its overexpression in prostate cancer patients. | Promoter polymorphisms of the PCA3 gene are not associated with its overexpression in prostate cancer patients.
Arámbula-Meraz E, Irigoyen-Arredondo M, Cedano-Prieto D, Romo-Martínez E, Luque-Ortega F, Picos-Cárdenas V, Alvarez-Arrazola M, García-Magallanes N. | 06/5/2021 |
| These results show that the lncRNAs PCA3 and HAM-1 are upregulated during thyroid tumor development and progression and may function as oncogenes during tumor progression | Long Non-coding RNA Expression in Anaplastic Thyroid Carcinomas.
Wang Y, Hardin H, Chu YH, Esbona K, Zhang R, Lloyd RV. | 06/6/2020 |
| Using information visualization methods, we could also distinguish between cell lines expressing the endogenous PCA3 long noncoding RNA (lncRNA) from cells that did not contain detectable levels of this biomarker. | Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors.
Soares JC, Soares AC, Rodrigues VC, Melendez ME, Santos AC, Faria EF, Reis RM, Carvalho AL, Oliveira ON Jr. | 05/9/2020 |
| PCA3 but not T2:ERG was associated with cancer reclassification in the first surveillance biopsy, but has negligible improvement over clinical variables alone in receiver operating characteristic curves or decision curve analyses. Neither marker was associated with reclassification in subsequent biopsies. | Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS).
Newcomb LF, Zheng Y, Faino AV, Bianchi-Frias D, Cooperberg MR, Brown MD, Brooks JD, Dash A, Fabrizio MD, Gleave ME, Liss M, Morgan TM, Thompson IM, Wagner AA, Carroll PR, Nelson PS, Lin DW., Free PMC Article | 04/4/2020 |
| Urine prostate cancer gene 3 (PCA3) is significantly elevated in patients with prostate cancer and can be used for the diagnosis of prostate cancer, but its cutoff value is still controversial--{REVIEW} | Comparison of diagnostic efficacy by two urine PCA3 scores in prostate cancer patients undergoing repeat biopsies.
Jiang Z, Zhao Y, Tian Y. | 12/7/2019 |
| Our data suggest that PCA3 improves the diagnostic sensitivity and specificity of PSA and that the combination of PCA3 with PSA gives better overall performance in identification of prostate cancer than serum prostate-specific antigen alone in the high-risk population | Combination of Prostate Cancer Antigen 3 and Prostate-Specific Antigen Improves Diagnostic Accuracy in Men at Risk of Prostate Cancer.
Cao L, Lee CH, Ning J, Handy BC, Wagar EA, Meng QH. | 07/6/2019 |
| The noncoding RNA Prostate Cancer Antigen 3 (PCA3) is a Prostate Cancer -specific early-detection biomarker quantifiable in tissues and in urine collected after digital rectal examination (DRE) that has been used in counseling and confirming initial and repeat biopsy. | Genomic Markers in Prostate Cancer Decision Making.
Cucchiara V, Cooperberg MR, Dall'Era M, Lin DW, Montorsi F, Schalken JA, Evans CP. | 02/2/2019 |
| The unusual increase in PCA3 gene expression in CML patients suggests the need for more research on mechanisms of molecular pathways related to PCA3 which could help achieve better treatment. | Gene expression analysis of noncoding PCA3 gene in patients with chronic myeloid leukemia.
Sajjadi E, Atashi A, Tajrishi MAMH, Saei Z. | 11/3/2018 |
| The urine PCA3 mRNA could be a biomarker for diagnosing patients with PC. | Urine PCA3 mRNA level in diagnostic of prostate cancer.
Li M, Zhou D, Zhang W, Gao S, Zhou X. | 10/27/2018 |
| Although the results demonstrated that SNP rs544190 was not involved in prostate cancer risk in Eastern Chinese descent, unlike in European population, these might have clinical implications on prostate cancer heterogeneity around the World. | PCA3 rs544190G>A and prostate cancer risk in an eastern Chinese population.
Cao D, Gu C, Ye D, Dai B, Zhu Y., Free PMC Article | 07/28/2018 |
| the urine PCA3 test has acceptable sensitivity and specificity for the diagnosis of prostate cancer and can be used as a non-invasive method for that purpose. | Evaluation of prostate cancer antigen 3 for detecting prostate cancer: a systematic review and meta-analysis.
Cui Y, Cao W, Li Q, Shen H, Liu C, Deng J, Xu J, Shao Q., Free PMC Article | 03/31/2018 |
| Research results show that lncRNA PCA3 may coordinate epithelial ovarian carcinoma tumorigenesis through disrupting miR-106b regulated gene expression. | The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression.
Liu Y, Zong ZH, Guan X, Wang LL, Zhao Y. | 09/30/2017 |
| expression in prostate upregulated in men with prostate cancer diagnosed at a future date | Evaluation of a short RNA within Prostate Cancer Gene 3 in the predictive role for future cancer using non-malignant prostate biopsies.
Pang KH, Rosario DJ, Morgan SL, Catto JW., Free PMC Article | 09/9/2017 |
| Study confirmed that elevated PCA3 promotes cell proliferation, migration and invasion while inhibiting cell apoptosis in prostate cancer cell line, possibly in part through up-regulation of GRP78. | GRP78 Participates in PCA3-regulated Prostate Cancer Progression.
Lin C, Wang J, Wang Y, Zhu P, Liu X, Li N, Liu J, Yu L, Wang W. | 09/9/2017 |
| Patients with Prostate cancer had significantly higher levels of the prostate cancer-associated gene PCA3 in post-digital rectal examination urine extracellular vesicles. Continued analysis of urine EVs offers the potential discovery of novel biomarkers for pre-biopsy Prostate cancer detection. | Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine.
Pellegrini KL, Patil D, Douglas KJS, Lee G, Wehrmeyer K, Torlak M, Clark J, Cooper CS, Moreno CS, Sanda MG., Free PMC Article | 08/26/2017 |
| The PCA3 score was directly associated both with biopsy Gleason score and Prostate Imaging Reporting and Data System grade: notably, in the 'indeterminate' Prostate Imaging Reporting and Data System grade 3 subgroup | High prostate cancer gene 3 (PCA3) scores are associated with elevated Prostate Imaging Reporting and Data System (PI-RADS) grade and biopsy Gleason score, at magnetic resonance imaging/ultrasonography fusion software-based targeted prostate biopsy after a previous negative standard biopsy.
De Luca S, Passera R, Cattaneo G, Manfredi M, Mele F, Fiori C, Bollito E, Cirillo S, Porpiglia F. | 05/27/2017 |
| PCA3 mRNA is elevated in the urine of Chinese patients with positive prostate cancer biopsy compared to negative biopsy. | Prostate cancer antigen 3 moderately improves diagnostic accuracy in Chinese patients undergoing first prostate biopsy.
Wang FB, Chen R, Ren SC, Shi XL, Zhu YS, Zhang W, Jing TL, Zhang C, Gao X, Hou JG, Xu CL, Sun YH., Free PMC Article | 03/4/2017 |
| Real-time elastography and PCA3 may be used as pre-biopsy examinations to reduce the number of prostate biopsies | A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy.
Nygård Y, Haukaas SA, Halvorsen OJ, Gravdal K, Frugård J, Akslen LA, Beisland C., Free PMC Article | 03/4/2017 |
| our data provide evidence that PCA3 silencing modulates the expression of key cancer-related genes in prostate cancer cells | PCA3 long noncoding RNA modulates the expression of key cancer-related genes in LNCaP prostate cancer cells.
Lemos AE, Ferreira LB, Batoreu NM, de Freitas PP, Bonamino MH, Gimba ER. | 02/18/2017 |
| Data indicate that the 3-Step Transcriptional Amplification System (PCA3-3STA) represents a prostate cancer (PCa)-specific expression system. | A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer.
Neveu B, Jain P, Têtu B, Wu L, Fradet Y, Pouliot F., Free PMC Article | 12/17/2016 |