| Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production. | Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE(2) production.
Xu X, Lu Y, Cao L, Miao Y, Li Y, Cui Y, Han T. | 07/31/2024 |
| Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells. | Lipopolysaccharide-mediated ATP signaling regulates interleukin-6 mRNA expression via the P2-purinoceptor in human dental pulp cells.
Orimoto A, Kitamura C, Ono K. | 02/15/2024 |
| Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways. | Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.
Li Y, Zhou M, Li H, Dai C, Yin L, Liu C, Li Y, Zhang E, Dong X, Ji H, Hu Q. | 01/30/2024 |
| The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases. | The role of P2Y(6) receptor in the pathogenesis of cardiovascular and inflammatory diseases.
Nishiyama K. | 01/29/2024 |
| Immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma: a multi-omics studies and single-cell sequencing analysis. | Immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma: a multi-omics studies and single-cell sequencing analysis.
Wu H, Dong X., Free PMC Article | 11/14/2023 |
| Pyrimidinergic receptor P2Y6 expression is elevated in lung adenocarcinoma and is associated with poor prognosis. | Pyrimidinergic receptor P2Y6 expression is elevated in lung adenocarcinoma and is associated with poor prognosis.
Wang X, Zhao B, Ren D, Hu X, Qiao J, Zhang D, Zhang Y, Pan Y, Fan Y, Liu L, Wang X, Ma H, Jia X, Song S, Zhao C, Liu J, Wang L. | 10/24/2023 |
| P2Y6 receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging. | P2Y(6) receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging.
Dundee JM, Puigdellívol M, Butler R, Cockram TOJ, Brown GC., Free PMC Article | 03/5/2023 |
| Purinergic Receptor P2Y6 Is a Negative Regulator of NK Cell Maturation and Function. | Purinergic Receptor P2Y(6) Is a Negative Regulator of NK Cell Maturation and Function.
Li Z, Gao Y, He C, Wei H, Zhang J, Zhang H, Hu L, Jiang W. | 09/25/2021 |
| The P2Y6 receptor signals through Galphaq /Ca(2+) /PKCalpha and Galpha13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration. | The P2Y(6) receptor signals through Gα(q) /Ca(2+) /PKCα and Gα(13) /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.
Girard M, Dagenais Bellefeuille S, Eiselt É, Brouillette R, Placet M, Arguin G, Longpré JM, Sarret P, Gendron FP. | 04/13/2021 |
| Investigating the associations of mucosal P2Y6 receptor expression and urinary ATP and ADP concentrations, with symptoms of overactive bladder. | Investigating the associations of mucosal P2Y6 receptor expression and urinary ATP and ADP concentrations, with symptoms of overactive bladder.
Firouzmand S, Ajori L, Towse J, Allameh F, Najafi S, Javed S, John B, Langley SEM, Fry CH, Young JS., Free PMC Article | 11/21/2020 |
| The expression of the P2Y6 receptor is regulated at the transcriptional level by p53. | The expression of the P2Y(6) receptor is regulated at the transcriptional level by p53.
Molle CM, Arguin G, Jemfer C, Placet M, Dagenais Bellefeuille S, Gendron FP. | 10/24/2020 |
| Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6. | Prostaglandin E(2) glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y(6).
Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T., Free PMC Article | 12/22/2018 |
| The present study shows that sustained activation of P2Y6R may contribute to intestinal tumorigenesis by blocking the apoptotic process and by contributing to chemoresistance, a substantial concern in the treatment of patients with CRC. | The G protein-coupled P2Y₆ receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis.
Placet M, Arguin G, Molle CM, Babeu JP, Jones C, Carrier JC, Robaye B, Geha S, Boudreau F, Gendron FP. | 07/14/2018 |
| UDP/P2Y6 receptor signaling is involved in the regulation of IgE-dependent degranulation in basophils, which might stimulate the P2Y6 receptor via the autocrine secretion of UTP. Thus, this receptor represents a potential target to regulate IgE-dependent degranulation in basophils during allergic diseases. | UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils.
Nakano M, Ito K, Yuno T, Soma N, Aburakawa S, Kasai K, Nakamura T, Takami H. | 05/26/2018 |
| Expression levels of P2Y6 receptor were higher in Parkinson's disease patients compared to healthy controls. | Microglia P2Y6 receptor is related to Parkinson's disease through neuroinflammatory process.
Yang X, Lou Y, Liu G, Wang X, Qian Y, Ding J, Chen S, Xiao Q., Free PMC Article | 01/13/2018 |
| These data suggest that, without infection, inactivated-H5N1 induces mRNA expression of IL-6 and CXCL8 by a mechanism, or mechanisms, requiring interaction between viral hemagglutinin and alpha-2,3 sialic acid receptors at the cell membrane of host cells, and involves activation of P2Y6 purinergic receptors. | P2Y6 receptors are involved in mediating the effect of inactivated avian influenza virus H5N1 on IL-6 & CXCL8 mRNA expression in respiratory epithelium.
Huipao N, Borwornpinyo S, Wiboon-Ut S, Campbell CR, Lee IH, Hiranyachattada S, Sukasem C, Thitithanyanont A, Pholpramool C, Cook DI, Dinudom A., Free PMC Article | 09/23/2017 |
| Rescuing miR-185 expression to inhibit P2Y6 may represent a therapeutic strategy against human aortic vascular smooth muscle cells dysfunction and hypertension. | miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation.
Wang S, Tang L, Zhou Q, Lu D, Duan W, Chen C, Huang L, Tan Y. | 09/9/2017 |
| data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells. | Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.
Ibusuki K, Sakiyama T, Kanmura S, Maeda T, Iwashita Y, Nasu Y, Sasaki F, Taguchi H, Hashimoto S, Numata M, Uto H, Tsubouchi H, Ido A. | 01/30/2016 |
| nucleotides released during the airway inflammatory processes will activate P2Y6 receptors, which will lead to further release of inflammatory cytokines. | P2Y6 receptor-mediated proinflammatory signaling in human bronchial epithelia.
Hao Y, Liang JF, Chow AW, Cheung WT, Ko WH., Free PMC Article | 06/20/2015 |
| high millimolar concentrations of ATP increased IL-8 and MCP-1 release by the glioma cells stimulated with suboptimal LPS concentration which were blocked by P2X7 and P2Y6 antagonists | Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.
Braganhol E, Kukulski F, Lévesque SA, Fausther M, Lavoie EG, Zanotto-Filho A, Bergamin LS, Pelletier J, Bahrami F, Ben Yebdri F, Fonseca Moreira JC, Battastini AM, Sévigny J. | 03/21/2015 |
| Data indicate that after P2Y6 receptor stimulation both phospholipase D (PLD) and DGKzeta enzymes are responsible for producing phosphatidic acid (PA). | Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.
Scott SA, Xiang Y, Mathews TP, Cho HP, Myers DS, Armstrong MD, Tallman KA, O'Reilly MC, Lindsley CW, Brown HA., Free PMC Article | 09/28/2013 |
| Using rat P2Y6 recombinant protein expressed in human astrocytoma cells, the authors found that the P2Y6 receptor is highly selective for UDP over UTP. | Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.
Nicholas RA, Watt WC, Lazarowski ER, Li Q, Harden K. | 03/19/2013 |
| Results indicate involvement of P2Y purinoceptors P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation. | P2Y receptors regulate proliferation of human pancreatic duct epithelial cells.
Ko T, An HJ, Ji YG, Kim OJ, Lee DH. | 10/27/2012 |
| no obvious correlation was found between the expression of P2Y6 and breast cancer cell proliferation | [Construction of P2Y6 constitutive knock down breast cancer cell line and evaluation of its proliferation].
Yang LL, Li RM, Pan XH, Qian M, Du B. | 09/1/2012 |
| Report role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women. | Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women.
Noronha-Matos JB, Costa MA, Magalhães-Cardoso MT, Ferreirinha F, Pelletier J, Freitas R, Neves JM, Sévigny J, Correia-de-Sá P. | 04/21/2012 |