| kappa-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-kappaB pathway. | κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway.
Shi Y, Tao H, Li X, Zhang L, Li C, Sun W, Chu M, Chen K, Zhu P, Wang Q, Gu C, Wang L, Yang X, Hao Y., Free PMC Article | 02/14/2024 |
| Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms. | Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.
Özkan-Kotiloğlu S, Kaya-Akyüzlü D, Yurdakul R, Yıldırım MA, Özgür-İlhan İ. | 07/13/2023 |
| Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone. | Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.
Hoye J, Key J, de Laat B, Cosgrove KP, Krishnan-Sarin S, Papademetris X, Morris ED. | 05/31/2023 |
| The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma. | The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma.
Lee SJ, Logsdon AF, Yagi M, Baskin BM, Peskind ER, Raskind MM, Cook DG, Schindler AG., Free PMC Article | 12/17/2022 |
| Opioids in cancer: The kappaopioid receptor (Review). | Opioids in cancer: The κ‑opioid receptor (Review).
Zhou Q, Zhang Z, Long S, Li W, Wang B, Liang N., Free PMC Article | 03/12/2022 |
| Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population. | Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population.
Yuferov V, Butelman ER, Randesi M, Ott J, Kreek MJ. | 03/5/2022 |
| Activation of kappa-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells. | Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells.
Zhang S, Yang F, Shi R, Liu C, Zhao L, Gu X, Liu Y, Fu F, Feng N, Liu Y, Jia M, Fan R, Yang L, Li J, Li J, Pei J. | 02/19/2022 |
| Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers. | Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers.
Albonaim A, Sharafshah A, Keshavarz P. | 02/12/2022 |
| Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography. | Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography.
Smart K, Yttredahl A, Oquendo MA, Mann JJ, Hillmer AT, Carson RE, Miller JM., Free PMC Article | 02/5/2022 |
| Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving. | Occupancy of the kappa opioid receptor by naltrexone predicts reduction in drinking and craving.
de Laat B, Nabulsi N, Huang Y, O'Malley SS, Froehlich JC, Morris ED, Krishnan-Sarin S. | 02/5/2022 |
| Oxytocin Is a Positive Allosteric Modulator of kappa-Opioid Receptors but Not delta-Opioid Receptors in the G Protein Signaling Pathway. | Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.
Miyano K, Yoshida Y, Hirayama S, Takahashi H, Ono H, Meguro Y, Manabe S, Komatsu A, Nonaka M, Mizuguchi T, Fujii H, Higami Y, Narita M, Uezono Y., Free PMC Article | 12/4/2021 |
| Non-neuronal kappa-opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo. | Non-neuronal kappa-opioid receptor activation enhances epidermal keratinocyte proliferation, and modulates mast cell functions in human skin ex vivo.
Chéret J, Gherardini J, Soeberdt M, Hundt JE, Abels C, Bertolini M, Paus R. | 06/26/2021 |
| OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study. | OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.
Ho KWD, Wallace MR, Staud R, Fillingim RB., Free PMC Article | 05/8/2021 |
| The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving. | The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving.
de Laat B, Goldberg A, Shi J, Tetrault JM, Nabulsi N, Zheng MQ, Najafzadeh S, Gao H, Kapinos M, Ropchan J, O'Malley SS, Huang Y, Morris ED, Krishnan-Sarin S. | 10/3/2020 |
| The OPRK1 rs3802279, rs3802281, and rs963549 genotypes were significantly associated with methadone dosage analyzed by Pearson's chi-square test or binary logistic regression to correct for covariates. The rs3802279 CC, rs3802281 TT, and rs963549 CC genotype carriers required a lower methadone maintenance dose per day. Multifactor analysis indicated strong interactions between sex and OPRK1 rs963549. | κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage.
Zhang Q, Shi M, Tang H, Zhong H, Lu X. | 06/27/2020 |
| Reactive oxygen species (ROS) generation is stimulated by kappa opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation | Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation.
Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C., Free PMC Article | 06/13/2020 |
| There was an inverse correlation between social status and KOR levels that was largely specific to the reward/aversion (e.g., saliency) areas of the brain. This finding suggests the KOR system may act as a mediator for the negative effects of social behaviors in humans. | Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers.
Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y., Free PMC Article | 03/21/2020 |
| Greater KOR availability was associated with more choices for cocaine in subjects with cocaine use disorder. | Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study.
Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y., Free PMC Article | 03/21/2020 |
| A history of child abuse specifically associated in the anterior insula with a downregulation of the kappa opioid receptor (Kappa), as well as decreased DNA methylation in the second intron of the Kappa gene. | Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse.
Lutz PE, Gross JA, Dhir SK, Maussion G, Yang J, Bramoulle A, Meaney MJ, Turecki G. | 10/19/2019 |
| An OPRK1 variant is associated with delayed onset of levodopa-induced dyskinesias in patients with Parkinson's disease. | Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinson's disease.
Cilia R, Asselta R, Cereda E, Benfante R, Barbella G, Vallauri D, Marabini L, Fornasari D, Goldwurm S, Pezzoli G. | 07/6/2019 |
| Alcohol-dependent subjects have a significantly lower kappa opioid receptor availability compared to healthy controls across multiple brain regions. | PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age.
Vijay A, Cavallo D, Goldberg A, de Laat B, Nabulsi N, Huang Y, Krishnan-Sarin S, Morris ED., Free PMC Article | 03/30/2019 |
| There was no association between OPRK1 SNPs and oral pain sensitivity. | Genetic Variations of OPRM1, OPRK1, and COMT Genes and Their Possible Associations with Oral Pain in a Population from Argentina.
Raggio MC, González R, Hohl DM, Glesmann LA, Catanesi CI. | 03/2/2019 |
| PDYN and OPRK1 showed transcriptionally coordinated pattern that was significantly different between alcoholics and controls. | Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.
Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Yakovleva T, Hansson AC, Sommer WH, Spanagel R, Bakalkin G., Free PMC Article | 03/2/2019 |
| Absolute expression levels of PDYN were lower compared to those of OPRK1, suggesting that PDYN expression is a limiting factor in the DYN/KOR signaling, and that the PDYN downregulation diminishes efficacy of DYN/KOR signaling in dorsolateral prefrontal cortex of human alcoholics. | Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.
Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Karpyak VM, Yakovleva T, Bakalkin G., Free PMC Article | 02/9/2019 |
| There was no significant change in the expression of KOR as a function of the insertion-deletion in the promoter region (rs35566036), or as a function of depression status in anterior insula, anterior cingulate cortex, or mediodorsal thalamus. This variant strongly determines DNA methylation in KOR promoter, leading to a significant decrease in methylation levels of 8 nearby CpG dinucleotides. | Epigenetic regulation of the kappa opioid receptor gene by an insertion-deletion in the promoter region.
Lutz PE, Almeida D, Belzeaux R, Yalcin I, Turecki G. | 01/19/2019 |