| TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster. | TTK Isoforms Interact with Two Regions of the Mep-1 Protein of Drosophila melanogaster.
Khalisova KY, Osadchiy IS, Georgiev PG, Maksimenko OG. | 09/25/2021 |
| Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69. | Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69.
Kitatani Y, Tezuka A, Hasegawa E, Yanagi S, Togashi K, Tsuji M, Kondo S, Parrish JZ, Emoto K., Free PMC Article | 09/26/2020 |
| Ttk69 plays a central role in shaping neural cell lineages . Ttk69 (1) promotes cell cycle exit of neural stem cells by downregulating CycE, and (2) regulates cell-fate acquisition and terminal differentiation, by downregulating the expression of hamlet and upregulating that of Suppressor of Hairless. | Shaping of Drosophila Neural Cell Lineages Through Coordination of Cell Proliferation and Cell Fate by the BTB-ZF Transcription Factor Tramtrack-69.
Simon F, Ramat A, Louvet-Vallée S, Lacoste J, Burg A, Audibert A, Gho M., Free PMC Article | 01/18/2020 |
| Ttk69 causes the histone deacetylation-mediated repression of tll via the interaction of Pits and Sin3A | Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation.
Liaw GJ., Free PMC Article | 07/7/2018 |
| N activity is required to promote dpn transcription; only in R7 photoreceptor precursors does the removal of Ttk coincide with high N activity; and only in this cell does Dpn expression result | R7 Photoreceptor Specification in the Developing Drosophila Eye: The Role of the Transcription Factor Deadpan.
Mavromatakis YE, Tomlinson A., Free PMC Article | 04/1/2017 |
| Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. | Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages.
Wang C, Guo X, Dou K, Chen H, Xi R. | 02/6/2016 |
| The presence and timing of ttk69 expression are essential for somatic muscle development and required for the balance between founder cells and fusion-competent myoblasts. | Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis.
Ciglar L, Girardot C, Wilczyński B, Braun M, Furlong EE., Free PMC Article | 08/23/2014 |
| Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror. | Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
Peters NC, Thayer NH, Kerr SA, Tompa M, Berg CA., Free PMC Article | 07/27/2013 |
| Tramtrack69 functions as a developmental switch in Drosophila follicle cells where it is regulated by miR-7. | The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells.
Huang YC, Smith L, Poulton J, Deng WM., Free PMC Article | 03/30/2013 |
| Ttk69 plays an instructive role in the growth of R7 photoreceptor axon terminals | R7 photoreceptor axon growth is temporally controlled by the transcription factor Ttk69, which inhibits growth in part by promoting transforming growth factor-β/activin signaling.
Kniss JS, Holbrook S, Herman TG., Free PMC Article | 03/23/2013 |
| The GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome of macrophages. | The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages.
Cumley NJ, Smith LM, Anthony M, May RC., Free PMC Article | 08/20/2012 |
| discovered multiple roles of Ttk in the development of the tracheal system on the morphogenetic level. Here, we sought to identify some of the underlying genetic components that are responsible for the tracheal phenotypes of Ttk mutants | Tramtrack is genetically upstream of genes controlling tracheal tube size in Drosophila.
Rotstein B, Molnar D, Adryan B, Llimargas M., Free PMC Article | 05/26/2012 |
| TTK69 is able to bind chromatin in the absence of NuRD, but targeting of NuRD is dependent on TTK69. | Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD.
Reddy BA, Bajpe PK, Bassett A, Moshkin YM, Kozhevnikova E, Bezstarosti K, Demmers JA, Travers AA, Verrijzer CP., Free PMC Article | 11/6/2010 |
| Results lead to conclude that Ttk69 can either directly or indirectly repress lz gene expression to prevent the premature development of R7 precursor cells in the developing eye of Drosophila. | Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc.
Siddall NA, Hime GR, Pollock JA, Batterham P., Free PMC Article | 03/1/2010 |
| Tramtrack69 (TTK69) controls the fates and shapes of all columnar follicle cells | Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation.
Boyle MJ, Berg CA., Free PMC Article | 02/15/2010 |
| Tramtrack (Ttk), a zinc-finger protein, is essential for the endocycle/gene amplification switch, is regulated negatively by Notch and positively by EcR. | Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling.
Sun J, Smith L, Armento A, Deng WM., Free PMC Article | 01/21/2010 |
| Sina protein may direct the degradation of the transcriptional repressor Tramtrack (Ttk) using two different mechanisms. | Two modes of degradation of the tramtrack transcription factors by Siah homologues.
Cooper SE, Murawsky CM, Lowe N, Travers AA., Free PMC Article | 01/21/2010 |
| Deubiquitinylating enzyme UBP64 controls cell fate through stabilization of tkk. | Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack.
Bajpe PK, van der Knaap JA, Demmers JA, Bezstarosti K, Bassett A, van Beusekom HM, Travers AA, Verrijzer CP., Free PMC Article | 01/21/2010 |
| Results suggest that the involvement of Tramtrack in different steps of tube morphogenesis identifies it as a key player in tracheal development. | Tramtrack regulates different morphogenetic events during Drosophila tracheal development.
Araújo SJ, Cela C, Llimargas M. | 01/21/2010 |
| Tramtrack downregulates Cyclin E expression and is probably involved in the exit of cells from the cell cycle. | Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage.
Audibert A, Simon F, Gho M. | 01/21/2010 |
| the binding of TTK69 prevents the interaction of GAGA with the transcription machinery and compromises its activation potential | Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69.
Pagans S, Piñeyro D, Kosoy A, Bernués J, Azorín F. | 01/21/2010 |
| identification of a novel allele of tramtrack | The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis.
French RL, Cosand KA, Berg CA. | 01/21/2010 |
| TTK69 is required for early (before the end of stage 4) repression of tll transcription. | Tramtrack69 is required for the early repression of tailless expression.
Chen YJ, Chiang CS, Weng LC, Lengyel JA, Liaw GJ. | 01/21/2010 |
| Using neural repression as an assay, we dissected functional domains of Ttk, confirming the importance of the bric-a-brac-tramtrack-broad complex (BTB) motif. | Tramtrack co-operates to prevent inappropriate neural development in Drosophila.
Badenhorst P, Finch JT, Travers AA. | 01/21/2010 |
| directly regulates the transcription of string and thereby cell proliferation | Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis.
Baonza A, Murawsky CM, Travers AA, Freeman M. | 01/21/2010 |