| Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis. | Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis.
Yin Z, Zhang L, Liu R, Tong L, Jiang C, Kang L. | 03/14/2023 |
| ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion. | ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion.
Kang N, Matsui TS, Liu S, Deguchi S., Free PMC Article | 03/26/2022 |
| An atomic model for the human septin hexamer by cryo-EM. | An atomic model for the human septin hexamer by cryo-EM.
Mendonça DC, Guimarães SL, Pereira HD, Pinto AA, de Farias MA, de Godoy AS, Araujo APU, van Heel M, Portugal RV, Garratt RC. | 09/25/2021 |
| The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma. | The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma.
Song K, Yu P, Zhang C, Yuan Z, Zhang H. | 08/21/2021 |
| Orientational Ambiguity in Septin Coiled Coils and its Structural Basis. | Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
Leonardo DA, Cavini IA, Sala FA, Mendonça DC, Rosa HVD, Kumagai PS, Crusca E Jr, Valadares NF, Marques IA, Brandão-Neto J, Munte CE, Kalbitzer HR, Soler N, Usón I, André I, Araujo APU, D'Muniz Pereira H, Garratt RC. | 06/26/2021 |
| MicroRNA7445p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype. | MicroRNA‑744‑5p is downregulated in colorectal cancer and targets SEPT2 to suppress the malignant phenotype.
Zhang W, Liao K, Liu D., Free PMC Article | 05/15/2021 |
| Molecular Recognition at Septin Interfaces: The Switches Hold the Key. | Molecular Recognition at Septin Interfaces: The Switches Hold the Key.
Rosa HVD, Leonardo DA, Brognara G, Brandão-Neto J, D'Muniz Pereira H, Araújo APU, Garratt RC. | 03/6/2021 |
| Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers. | Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.
Kim J, Cooper JA., Free PMC Article | 02/6/2021 |
| The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer. | The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer.
Xing Z, Li S, Liu Z, Zhang C, Meng M, Bai Z., Free PMC Article | 12/12/2020 |
| Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis. | Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
Collins KB, Kang H, Matsche J, Klomp JE, Rehman J, Malik AB, Karginov AV., Free PMC Article | 09/19/2020 |
| Analysis of the enrichment of gene ontology cellular components highlighted some important interactions between molecules involved in the spliceosome with septin 2 and septin 7 in particular. | Protein-protein interaction analysis highlights the role of septins in membrane enclosed lumen and mRNA processing.
Desterke C, Gassama-Diagne A. | 07/11/2020 |
| Repression of SEPTIN2 and SEPTIN9 suppresses tumor growth of human glioblastoma cells and tumor progression in a mouse model. | Repression of Septin9 and Septin2 suppresses tumor growth of human glioblastoma cells.
Xu D, Liu A, Wang X, Chen Y, Shen Y, Tan Z, Qiu M., Free PMC Article | 11/30/2019 |
| HCC with high expression of CDK2 and SEPT2 might be more aggressive and respond poorly to current therapy. | Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma.
Xu C, Zhang W, Zhang X, Zhou D, Qu L, Liu J, Xiao M, Ni R, Jiang F, Ni W, Lu C., Free PMC Article | 02/16/2019 |
| Results demonstrate that in stored platelets, septine-2 and septin-6 mRNAs have miR- 223 target sites, septin-2 and septin-6 are in complex with Ago-2. The results demonstrate that like in nucleated cells, enucleated platelets also have microRNA-based mechanisms for the regulation of their septins. | MicroRNA-223 Regulates Septin-2 and Septin-6 in Stored Platelets.
Chattopadhyay M, Dahiya N, Atreya C. | 12/22/2018 |
| Study discloses both SEPT2 and SEPT7 are essential for breast cancer cell migration and invasion by controlling MEK/ERK MAPKs activation. | The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation.
Zhang N, Liu L, Fan N, Zhang Q, Wang W, Zheng M, Ma L, Li Y, Shi L., Free PMC Article | 02/3/2018 |
| Depletion of septin 2 reduces Drp1 recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission. | A role for septin 2 in Drp1-mediated mitochondrial fission.
Pagliuso A, Tham TN, Stevens JK, Lagache T, Persson R, Salles A, Olivo-Marin JC, Oddos S, Spang A, Cossart P, Stavru F., Free PMC Article | 08/19/2017 |
| septins protect ErbB2 from ubiquitylation, endocytosis and lysosomal degradation. Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells. | Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells.
Marcus EA, Tokhtaeva E, Turdikulova S, Capri J, Whitelegge JP, Scott DR, Sachs G, Berditchevski F, Vagin O., Free PMC Article | 05/20/2017 |
| The results showed that SEPT2 has an oncogenic function through accelerated cell proliferation and invasion in biliary tract cancers, and is negatively regulated by miR-140-5p. | Septin 2 accelerates the progression of biliary tract cancer and is negatively regulated by mir-140-5p.
Yu J, Zhang W, Tang H, Qian H, Yang J, Zhu Z, Ren P, Lu B. | 01/28/2017 |
| From the nucleotide-free structure some interesting conclusions about the nucleotide binding properties of Cdc11 can be drawn; especially when aligning the structure with the structure of GDP bound Sept2 | Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae.
Brausemann A, Gerhardt S, Schott AK, Einsle O, Große-Berkenbusch A, Johnsson N, Gronemeyer T. | 11/5/2016 |
| These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 upregulation in Hodgkin lymphoma. | SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma.
Jian W, Zhong L, Wen J, Tang Y, Qiu B, Wu Z, Yan J, Zhou X, Zhao T., Free PMC Article | 04/23/2016 |
| Data indicate that forchlorfenuron (FCF) exhibits differential binding preference for septins SEPT2 and SEPT3. | In silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP binding.
Angelis D, Karasmanis EP, Bai X, Spiliotis ET., Free PMC Article | 06/27/2015 |
| Authors report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion. | Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion.
Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G., Free PMC Article | 06/20/2015 |
| Suggest PPAR-gamma activation down-regulates hepatocellular carcinoma cell SEPT2 levels to prevent tumor growth. | Activation of peroxisome proliferator-activated receptor-γ (PPARγ) inhibits hepatoma cell growth via downregulation of SEPT2 expression.
Cao LQ, Shao ZL, Liang HH, Zhang DW, Yang XW, Jiang XF, Xue P. | 04/11/2015 |
| SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9. | Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.
Ghossoub R, Hu Q, Failler M, Rouyez MC, Spitzbarth B, Mostowy S, Wolfrum U, Saunier S, Cossart P, Jamesnelson W, Benmerah A., Free PMC Article | 03/1/2014 |
| The results shown in study support the hypothesis that single Septin 2, when present in excess or with unbalanced stoichiometries, may be unstable and assemble into amyloid-like structures. | Self assembly of human septin 2 into amyloid filaments.
Pissuti Damalio JC, Garcia W, Alves Macêdo JN, de Almeida Marques I, Andreu JM, Giraldo R, Garratt RC, Ulian Araújo AP. | 06/9/2012 |