| NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors. | NAB2::STAT6 fusions and genome-wide DNA methylation profiling: Predictors of patient outcomes in meningeal solitary fibrous tumors.
Eschbacher KL, Tran QT, Moskalev EA, Jenkins S, Fritchie K, Stoehr R, Caron A, Link MJ, Brown PD, Guajardo A, Brat DJ, Wu A, Santagata S, Louis DN, Brastianos PK, Kaplan AB, Alexander B, Rossi S, Ferrarese F, Raleigh DR, Nguyen MP, Gross J, Velazquez Vega J, Rodriguez F, Perry A, Martinez-Lage M, Orr BA, Haller F, Giannini C., Free PMC Article | 10/23/2024 |
| Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle. | Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle.
Shirakura T, Yamada Y, Nakata S, Asayama B, Seo Y, Tanikawa S, Kato T, Komoribayashi N, Kubo N, Monma N, Okura N, Tanaka S, Oda Y, Hirato J, Yokoo H, Nobusawa S. | 01/11/2023 |
| Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities? | Teratocarcinosarcoma-Like and Adamantinoma-Like Head and Neck Neoplasms Harboring NAB2::STAT6: Unusual Variants of Solitary Fibrous Tumor or Novel Tumor Entities?
Stevens TM, Rooper LM, Bacchi CE, Fernandes IL, Antonescu CR, Gagan J, Bishop JA., Free PMC Article | 09/3/2022 |
| Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour. | Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour.
Georgiesh T, Namløs HM, Sharma N, Lorenz S, Myklebost O, Bjerkehagen B, Meza-Zepeda LA, Boye K. | 02/5/2022 |
| Lipomatous Solitary Fibrous Tumors Harbor Rare NAB2-STAT6 Fusion Variants and Show Up-Regulation of the Gene PPARG, Encoding for a Regulator of Adipocyte Differentiation. | Lipomatous Solitary Fibrous Tumors Harbor Rare NAB2-STAT6 Fusion Variants and Show Up-Regulation of the Gene PPARG, Encoding for a Regulator of Adipocyte Differentiation.
Haller F, Schlieben LD, Ferrazzi F, Michal M, Stöhr R, Moskalev EA, Bieg M, Bovée JVMG, Ströbel P, Ishaque N, Grützmann R, Meidenbauer N, Eils R, Wiemann S, Hartmann A, Michal M, Agaimy A. | 07/31/2021 |
| NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation. | NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation.
Park YS, Kim HS, Kim JH, Choi SH, Kim DS, Ryoo ZY, Kim JY, Lee S. | 04/24/2021 |
| Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants. | Gene Expression in Solitary Fibrous Tumors (SFTs) Correlates with Anatomic Localization and NAB2-STAT6 Gene Fusion Variants.
Bieg M, Moskalev EA, Will R, Hebele S, Schwarzbach M, Schmeck S, Hohenberger P, Jakob J, Kasper B, Gaiser T, Ströbel P, Wardelmann E, Kontny U, Braunschweig T, Sirbu H, Grützmann R, Meidenbauer N, Ishaque N, Eils R, Wiemann S, Hartmann A, Agaimy A, Fritchie K, Giannini C, Haller F. | 04/17/2021 |
| NAB2-STAT6 fusion type was not significantly associated with recurrence-free or overall survival, but was associated with phenotype | The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.
Fritchie K, Jensch K, Moskalev EA, Caron A, Jenkins S, Link M, Brown PD, Rodriguez FJ, Guajardo A, Brat D, Velázquez Vega JE, Perry A, Wu A, Raleigh DR, Santagata S, Louis DN, Brastianos PK, Kaplan A, Alexander BM, Rossi S, Ferrarese F, Haller F, Giannini C., Free PMC Article | 03/28/2020 |
| Study characterized sequences in NAB2 that mediate its nuclear localization and determined that the KKXK motif that aligns with the NAB1 KRXK motif is necessary for NAB2 nuclear localization, while the K(X2)R motif situated 11 residues upstream is not. | Refining the nuclear localization signal within the Egr transcriptional coregulator NAB2.
LaVallee J, Grant T, D'Angelo-Early S, Kletsov S, Berry NA, Abt KM, Bloch CP, Muscedere ML, Adams KW. | 07/13/2019 |
| Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours. | Recurrent NAB2-STAT6 gene fusions and oestrogen receptor-α expression in pulmonary adenofibromas.
Fusco N, Guerini-Rocco E, Augello C, Terrasi A, Ercoli G, Fumagalli C, Vacirca D, Braidotti P, Parafioriti A, Jaconi M, Runza L, Ananthanarayanan V, Pagni F, Bosari S, Barberis M, Ferrero S. | 08/26/2017 |
| Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor | Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature.
Yuzawa S, Nishihara H, Wang L, Tsuda M, Kimura T, Tanino M, Tanaka S. | 07/29/2017 |
| The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics. | Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour.
Koelsche C, Schweizer L, Renner M, Warth A, Jones DT, Sahm F, Reuss DE, Capper D, Knösel T, Schulz B, Petersen I, Ulrich A, Renker EK, Lehner B, Pfister SM, Schirmacher P, von Deimling A, Mechtersheimer G. | 04/15/2017 |
| Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges. | Clinicopathological differences between variants of the NAB2-STAT6 fusion gene in solitary fibrous tumors of the meninges and extra-central nervous system.
Nakada S, Minato H, Nojima T. | 01/28/2017 |
| NAB2-STAT6 fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain. | 'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion.
Ishizawa K, Tsukamoto Y, Ikeda S, Suzuki T, Homma T, Mishima K, Nishikawa R, Sasaki A. | 12/17/2016 |
| the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type. | The clinicopathological significance of NAB2-STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors.
Huang SC, Li CF, Kao YC, Chuang IC, Tai HC, Tsai JW, Yu SC, Huang HY, Lan J, Yen SL, Lin PC, Chen TC., Free PMC Article | 10/22/2016 |
| Case Report: NAB2-STAT6 fusion in glioblastoma. | Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma.
Diamandis P, Ferrer-Luna R, Huang RY, Folkerth RD, Ligon AH, Wen PY, Beroukhim R, Ligon KL, Ramkissoon SH., Free PMC Article | 10/22/2016 |
| We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors | NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors.
Tai HC, Chuang IC, Chen TC, Li CF, Huang SC, Kao YC, Lin PC, Tsai JW, Lan J, Yu SC, Yen SL, Jung SM, Liao KC, Fang FM, Huang HY. | 08/20/2016 |
| This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts. | NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor.
Fritchie KJ, Jin L, Rubin BP, Burger PC, Jenkins SM, Barthelmeß S, Moskalev EA, Haller F, Oliveira AM, Giannini C. | 07/16/2016 |
| It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites. | NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases.
Nakada S, Minato H, Takegami T, Kurose N, Ikeda H, Kobayashi M, Sasagawa Y, Akai T, Kato T, Yamamoto N, Nojima T. | 06/11/2016 |
| This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features. | Malignant solitary fibrous tumor with high-grade nuclear atypia: an alternate entity for the undetermined tumor group.
Yamada Y, Kohashi K, Bekki H, Ishii T, Iura K, Maekawa A, Yamamoto H, Iwamoto Y, Oda Y. | 10/31/2015 |
| also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17 | [Two Cases of Primary Intracranial Solitary Fibrous Tumor:Genetic Examination of NAB2-STAT6 Fusion and Its Association with Hemangiopericytoma].
Kikuchi A, Fujita T, Takahashi Y, Yokosako S, Yoshimura C, Akagawa H, Fujibayashi M, Kubo O, Onda H, Kasuya H. | 10/31/2015 |
| There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201). | Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.
Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T. | 05/23/2015 |
| reverse transcriptase PCR analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity | FDG PET/CT and MR imaging of CD34-negative soft-tissue solitary fibrous tumor with NAB2-STAT6 fusion gene.
Nishio J, Iwasaki H, Aoki M, Nabeshima K, Naito M. | 04/11/2015 |
| Tumors with the most common fusion variant, NAB2ex4-STAT6ex2/3, corresponded to classic pleuropulmonary solitary fibrous tumors with diffuse fibrosis and mostly benign behavior and occurred in older patients | Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features.
Barthelmeß S, Geddert H, Boltze C, Moskalev EA, Bieg M, Sirbu H, Brors B, Wiemann S, Hartmann A, Agaimy A, Haller F. | 12/6/2014 |
| 44 SFTs were studied to identify pathogenetically important genetic rearrangements. RT-PCR analysis identified a NAB2/STAT6 fusion in 37/41 cases. | Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor.
Mohajeri A, Tayebwa J, Collin A, Nilsson J, Magnusson L, von Steyern FV, Brosjö O, Domanski HA, Larsson O, Sciot R, Debiec-Rychter M, Hornick JL, Mandahl N, Nord KH, Mertens F. | 02/8/2014 |